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The patients were divided into two groups based on EARR values measured on periapical radiographs: The significant resorption group (SG, EARR\u2009\u2265\u20094\u00a0mm) and the normal group (NG, EARR\u2009&lt;\u20092\u00a0mm). In the NG group, patients with EARR\u2009&lt;\u20091\u00a0mm were named the non-resorption group (NonG). Targeted next-generation sequencing was performed using the screened single nucleotide polymorphisms (SNPs), and firth logistic regression analysis was used to determine genetic associations with EARR. Haplotype-based association analysis was performed for specific SNPs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>SNPs related to genes <jats:italic>TNFSF11<\/jats:italic>, <jats:italic>TNFRSF11B<\/jats:italic>, <jats:italic>WNT3A<\/jats:italic>, <jats:italic>SFRP2, LRP6<\/jats:italic>, <jats:italic>P2RX7<\/jats:italic>, and <jats:italic>LRP1<\/jats:italic> were found to be significantly associated with severe EARR (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, pre-Bonferroni correction <jats:italic>p<\/jats:italic>-values). Additionally, the haplotype CCA of rs17525809, rs208294, and rs1718119 <jats:italic>P2RX7<\/jats:italic> had a higher frequency in the SG group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Extreme phenotype analysis has identified eleven SNPs related to genes <jats:italic>TNFSF11<\/jats:italic>, <jats:italic>TNFRSF11B<\/jats:italic>, <jats:italic>WNT3A<\/jats:italic>, <jats:italic>SFRP2<\/jats:italic>, <jats:italic>LRP6<\/jats:italic>, <jats:italic>P2RX7<\/jats:italic>, and <jats:italic>LRP1<\/jats:italic> that are associated with severe root resorption in the Korean population. These findings will contribute to the development of predictive diagnostic tools for identifying severe root resorption that may occur during orthodontic treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40510-024-00521-7","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:01:34Z","timestamp":1717977694000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genetic polymorphisms linked to extreme postorthodontic external apical root resorption in Koreans"],"prefix":"10.1186","volume":"25","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwanwoo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Jeong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8761-3819","authenticated-orcid":false,"given":"Jung-Yul","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"issue":"1","key":"521_CR1","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12903-018-0579-2","volume":"18","author":"Y Deng","year":"2018","unstructured":"Deng Y, Sun Y, Xu T. 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