{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:31:21Z","timestamp":1792794681417,"version":"4.5.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bot Stud"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Recently, researchers are focusing on creating new tools to combat the antibiotic resistant bacteria and malignancy issues, which pose significant threats to humanity. Biosynthesized silver nanoparticles (AgNPs) are thought to be a potential solution to these issues. The biosynthesis method, known for its environmentally friendly and cost-effective characteristics, can produce small-sized AgNPs with antimicrobial and anticancer properties. In this study, AgNPs were bio-fabricated from the distilled water and methanolic extracts of <jats:italic>Viburnum grandiflorum<\/jats:italic> leaves. Physio-chemical characterization of the bio-fabricated AgNPs was conducted using UV-visible spectroscopy, scanning electron microscopy, energy dispersive X-ray, and X-ray diffraction analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>AgNPs produced from the methanol extract were smaller in size (12.28\u00a0nm) compared to those from the aqueous extract (17.77\u00a0nm). The bioengineered AgNPs exhibited a circular shape with a crystalline nature. These biosynthesized AgNPs demonstrated excellent bactericidal activity against both gram-negative (<jats:italic>Pseudomonas aeruginosa<\/jats:italic>) and gram-positive (<jats:italic>Staphylococcus aureus<\/jats:italic>) bacteria. Highest antibacterial activity was observed with the methanol extract against <jats:italic>P. aeruginosa<\/jats:italic> (14.66\u2009\u00b1\u20090.74\u00a0mm). AgNPs from the methanol extract also displayed the highest antioxidant activity, with an IC<jats:sub>50<\/jats:sub> value of 188.00\u2009\u00b1\u20092.67\u00a0\u03bcg\/mL against 2,2-diphenyl-1-picrylhydrazyl (DPPH). Furthermore, AgNPs exhibited notable cytotoxic activity against Rhabdomyosarcoma cell line (RD cell) of human muscle cancer cell. The IC<jats:sub>50<\/jats:sub> values calculated from the MTT assay were 26.28\u2009\u00b1\u20091.58 and 21.49\u2009\u00b1\u20091.44\u00a0\u03bcg\/mL for AgNPs synthesized from aqueous and methanol extracts, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The methanol extract of <jats:italic>V. grandiflorum<\/jats:italic> leaves demonstrates significant potential for synthesizing AgNPs with effective antibacterial, antioxidant, and anticancer actions, making them applicable in various biomedical applications.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40529-024-00411-5","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T10:02:31Z","timestamp":1705917751000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Antibacterial, antioxidant, and anticancer potential of green fabricated silver nanoparticles made from Viburnum grandiflorum leaf extract"],"prefix":"10.1186","volume":"65","author":[{"given":"Hina","family":"Talib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansar","family":"Mehmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Shoaib","family":"Amjad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amna","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Abdul Rauf","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Raffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizwan Taj","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khawaja Shafique","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huma","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"key":"411_CR1","doi-asserted-by":"publisher","first-page":"73793","DOI":"10.1039\/C5RA13206A","volume":"5","author":"A Ahmad","year":"2015","unstructured":"Ahmad A, Syed F, Shah A, Khan Z, Tahir K, Khan AU, Yuan Q (2015) Silver and gold nanoparticles from Sargentodoxa cuneata: synthesis, characterization and antileishmanial activity. 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