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The Alzheimer\u2019s disease (AD) is ranked one of the top ten leading causes of death worldwide. Little is known about the effects of hispolon on delaying AD progression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The hispolon (No.1) and its six structural analogs (No.2 to No.7) were assayed by antioxidant, anti-acetylcholinesterase activities and anti-amyloid-\u03b2\n                      <jats:sub>1-42<\/jats:sub>\n                      -peptide aggregations. The No.1, No.6, and No.7 were selected for further molecular docking with acetylcholinesterase and core fragments of amyloid-\u03b2-peptide, and also showed capacities to recover cell viabilities in methylglyoxal-treated SH-SY5Y cells and also to enhance neurite outgrowths in PC12 cells. The daily pre-treatments of No.1, No.6, and No.7 for 10-days (40\u00a0mg\/kg\/day) showed to improve learning dysfunctions in scopolamine-induced ICR mice by passive avoidance tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The hispolon in the fungus sang-huang might be beneficial to develop functional foods or as lead compounds for treating degenerative disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40529-024-00443-x","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T03:57:26Z","timestamp":1734494246000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antioxidant, anti-acetylcholinesterase, and anti-amyloid-\u03b2 peptide aggregations of hispolon and its analogs in vitro and improved learning and memory functions in scopolamine-induced ICR mice"],"prefix":"10.1186","volume":"65","author":[{"given":"Chang-Hang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Yan","family":"Sie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Chieh","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hsiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-7018","authenticated-orcid":false,"given":"Wen-Chi","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"443_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3389\/fnins.2015.00023","volume":"9","author":"I Allaman","year":"2015","unstructured":"Allaman I, B\u00e9langer M, Magistretti PJ (2015) Methylglyoxal, the dark side of glycolysis. 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