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In addition, there is early evidence that the high dose of corticosteroids used can have systemic side effects. We describe the results of a case series evaluating the use of platelet lysate (PL) epidural injections for the treatment of lumbar radicular pain as an alternative to corticosteroids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Registry data was obtained for patients (<jats:italic>N<\/jats:italic> = 470) treated with PL epidural injections presenting with symptoms of lumbar radicular pain and MRI findings that were consistent with symptoms. Collected outcomes included numeric pain score (NPS), functional rating index (FRI), and a modified single assessment numeric evaluation (SANE) rating.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients treated with PL epidurals reported significantly lower (<jats:italic>p<\/jats:italic> &lt;. 0001) NPS and FRI change scores at all time points compared to baseline. Post\u2010treatment FRI change score means exceeded the minimal clinically important difference beyond 1\u00a0month. Average modified SANE ratings showed 49.7% improvement at 24\u00a0months post\u2010treatment. Twenty\u2010nine (6.3%) patients reported mild adverse events related to treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients treated with PL epidurals reported significant improvements in pain, exceeded the minimal clinically important difference (MCID) for FRI, and reported subjective improvement through 2\u2010year follow\u2010up. PL may be a promising substitute for corticosteroid.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s40634-017-0113-5","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T20:44:36Z","timestamp":1511556276000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["The use of lumbar epidural injection of platelet lysate for treatment of radicular pain"],"prefix":"10.1002","volume":"4","author":[{"given":"Christopher","family":"Centeno","sequence":"first","affiliation":[{"name":"Centeno\u2010Schultz Clinic 80021 Broomfield CO USA"},{"name":"Regenexx LLC 50321 Des Moines IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Markle","sequence":"additional","affiliation":[{"name":"Centeno\u2010Schultz Clinic 80021 Broomfield CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5808-6068","authenticated-orcid":false,"given":"Ehren","family":"Dodson","sequence":"additional","affiliation":[{"name":"Centeno\u2010Schultz Clinic 80021 Broomfield CO USA"},{"name":"Regenexx LLC 50321 Des Moines IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Stemper","sequence":"additional","affiliation":[{"name":"Regenexx LLC 50321 Des Moines IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Hyzy","sequence":"additional","affiliation":[{"name":"Centeno\u2010Schultz Clinic 80021 Broomfield CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Williams","sequence":"additional","affiliation":[{"name":"Centeno\u2010Schultz Clinic 80021 Broomfield CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Freeman","sequence":"additional","affiliation":[{"name":"CAPHRI School of Public Health and Primary Care Maastricht University Maastricht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,25]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"1","article-title":"Effects of local Administration of Platelet Rich Plasma on functional recovery after bridging sciatic nerve defect using silicone rubber chamber; an experimental study. 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