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Their surgical intervention is multifarious and the most favourable treatment is chosen by the orthopaedic surgeon on a case\u2010by\u2010case basis depending on a number of factors related with the patient and the lesion. Numerous regenerative tissue engineering strategies have been developed and studied extensively in laboratory through in vitro experiments and preclinical in vivo trials with various established animal models, while a small proportion of them reached the operating room. However, based on the available literature, the current strategies have not yet achieved to fully solve the clinical problems. Thus, the gold standards, if existing, remain unchanged in the clinics, notwithstanding the known limitations and drawbacks. Herein, the involvement of regenerative tissue engineering in the clinical orthopaedics is reviewed. The current challenges are indicated and discussed in order to describe the current disequilibrium between the needs and solutions made available in the operating room. Regenerative tissue engineering is a very dynamic field that has a high growth rate and a great openness and ability to incorporate new technologies with passion to edge towards the Holy Grail that is functional tissue regeneration. Thus, the future of clinical solutions making use of regenerative tissue engineering principles for the management of orthopaedic disorders is firmly supported by the clinical need.<\/jats:p>","DOI":"10.1186\/s40634-018-0133-9","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T08:03:29Z","timestamp":1526976209000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Orthopaedic regenerative tissue engineering en route to the holy grail: disequilibrium between the demand and the supply in the operating room"],"prefix":"10.1002","volume":"5","author":[{"given":"Ibrahim Fatih","family":"Cengiz","sequence":"first","affiliation":[{"name":"3B\u2019s Research Group I3Bs \u2013 Research Institute on Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark, Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra, 4805\u2010017 Barco Guimar\u00e3es Portugal"},{"name":"ICVS\/3B\u2019s \u2013 PT Government Associate Laboratory Braga\/Guimar\u00e3es Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9lder","family":"Pereira","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group I3Bs \u2013 Research Institute on Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark, Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra, 4805\u2010017 Barco Guimar\u00e3es Portugal"},{"name":"ICVS\/3B\u2019s \u2013 PT Government Associate Laboratory Braga\/Guimar\u00e3es Portugal"},{"name":"Ripoll y De Prado Sports Clinic: Murcia\u2010Madrid FIFA Medical Centre of Excellence Madrid Spain"},{"name":"Orthopedic Department Centro Hospitalar P\u00f3voa de Varzim Vila do Conde 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