{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:41:52Z","timestamp":1760640112708,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":230,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":230,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. exp. orthop."],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>\u201cBiologic therapies\u201d in the field of orthopaedic surgery and sports medicine, so called orthobiologics, have been gaining significant interest from physicians and patients, with increasing usage over the recent years. The aim of this study is to (1) evaluate the usage of orthobiologics in the Netherlands, (2) to clarify the reasons for the use or non\u2010use of orthobiologics, and (3) the most addressed disease for use of orthobiologics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors created a 19\u2010quenstion online survey comprised of both closed\u2010ended and open\u2010ended response questions in order to examine the use of and the indication for orthobiologics. The survey was sent to all the members of the Dutch Orthopaedic Association and Netherlands Association of Sports Medicine of which 15% responded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority of the 265 respondents (65%) did not treat patients with or refer patients for treatment with orthobiologics. The most important reasons for not using orthobiologics were the lack of scientific evidence, the lack of good experience, and the lack of insurance coverage. Of the physicians that used orthobiologics, the most used hyaluronic acid (76%) and platelet\u2010rich plasma (27%). Orthobiologics were most used for knee osteoarthritis and medial or lateral epicondylitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although some orthobiologic treatments might be effective and the research interest is growing, our study shows that the majority of orthopaedic and sport physician clinicians in the Netherlands still does not make use of orthobiologics as a treatment option, but almost a third of them is contemplating to start using orthobiologics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>III.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s40634-021-00380-9","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T13:35:08Z","timestamp":1629380108000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Orthobiologics and hyaluronic acid usage in the Netherlands: an electronic survey of 265 orthopaedic surgeons and sports physicians"],"prefix":"10.1002","volume":"8","author":[{"given":"J. J.","family":"de Graeff","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Joint Research OLVG Oosterpark 9 1091 AC Amsterdam the Netherlands"},{"name":"Department of Orthopaedic Surgery Leiden University Medical Center PO Box 9600 2300 RC Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P. J.","family":"van den Bekerom","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Joint Research OLVG Oosterpark 9 1091 AC Amsterdam the Netherlands"},{"name":"Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences Amsterdam Movement Sciences Vrije Universiteit Amsterdam Van der Boechorststraat 7 1081 BT Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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C.","family":"Zijl","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery St. Antonius Hospital Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Dutch Arthroscopy Society","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACM.0000000000002094"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.06.011"},{"issue":"5","key":"e_1_2_9_4_2","first-page":"857","article-title":"HYADD 4 versus methylprednisolone acetate in symptomatic knee osteoarthritis: a single\u2010centre single blind prospective randomised controlled clinical study with 1\u2010year follow\u2010up","volume":"34","author":"Bisicchia S","year":"2016","journal-title":"Clin Exp 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