{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T23:39:17Z","timestamp":1783640357854,"version":"3.55.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100004702","name":"Baxter","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100004702","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["ICMx"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Invasive mechanical ventilation is lifesaving in the setting of severe acute respiratory failure but can cause ventilation-induced lung injury. Advances in extracorporeal CO<jats:sub>2<\/jats:sub> removal (ECCO<jats:sub>2<\/jats:sub>R) technologies may facilitate more protective lung ventilation in acute respiratory distress syndrome, and enable earlier weaning and\/or avoid invasive mechanical ventilation entirely in chronic obstructive pulmonary disease exacerbations. We evaluated the in vitro CO<jats:sub>2<\/jats:sub> removal capacity of the novel PrismaLung+ ECCO<jats:sub>2<\/jats:sub>R device compared with two existing gas exchangers.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The in vitro CO<jats:sub>2<\/jats:sub> removal capacity of the PrismaLung+ (surface area 0.8\u2009m<jats:sup>2<\/jats:sup>, Baxter) was compared with the PrismaLung (surface area 0.35\u2009m<jats:sup>2<\/jats:sup>, Baxter) and A.L.ONE (surface area 1.35\u2009m<jats:sup>2<\/jats:sup>, Eurosets) devices, using a closed-loop bovine blood\u2013perfused extracorporeal circuit. The efficacy of each device was measured at varying pCO<jats:sub>2<\/jats:sub> inlet (p<jats:sub>in<\/jats:sub>CO<jats:sub>2<\/jats:sub>) levels (45, 60, and 80\u2009mmHg) and blood flow rates (<jats:italic>Q<\/jats:italic><jats:sub>B<\/jats:sub>) of 200\u2013450\u2009mL\/min; the PrismaLung+ and A.L.ONE devices were also tested at a <jats:italic>Q<\/jats:italic><jats:sub>B<\/jats:sub> of 600\u2009mL\/min. The amount of CO<jats:sub>2<\/jats:sub> removed by each device was assessed by measurement of the CO<jats:sub>2<\/jats:sub> infused to maintain circuit equilibrium (CO<jats:sub>2<\/jats:sub> infusion method) and compared with measured CO<jats:sub>2<\/jats:sub> concentrations in the inlet and outlet of the CO<jats:sub>2<\/jats:sub> removal device (blood gas analysis method).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The PrismaLung+ device performed similarly to the A.L.ONE device, with both devices demonstrating CO<jats:sub>2<\/jats:sub> removal rates ~ 50% greater than the PrismaLung device. CO<jats:sub>2<\/jats:sub> removal rates were 73 \u00b1 4.0, 44 \u00b1 2.5, and 72 \u00b1 1.9\u2009mL\/min, for PrismaLung+, PrismaLung, and A.L.ONE, respectively, at <jats:italic>Q<\/jats:italic><jats:sub>B<\/jats:sub> 300\u2009mL\/min and p<jats:sub>in<\/jats:sub>CO<jats:sub>2<\/jats:sub> 45\u2009mmHg. A Bland\u2013Altman plot demonstrated that the CO<jats:sub>2<\/jats:sub> infusion method was comparable to the blood gas analysis method for calculating CO<jats:sub>2<\/jats:sub> removal. The resistance to blood flow across the test device, as measured by pressure drop, varied as a function of blood flow rate, and was greatest for PrismaLung and lowest for the A.L.ONE device.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The newly developed PrismaLung+ performed more effectively than PrismaLung, with performance of CO<jats:sub>2<\/jats:sub> removal comparable to A.L.ONE at the flow rates tested, despite the smaller membrane surface area of PrismaLung+ versus A.L.ONE. Clinical testing of PrismaLung+ is warranted to further characterize its performance.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40635-020-00301-7","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T11:03:31Z","timestamp":1589367811000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["In vitro characterization of PrismaLung+: a novel ECCO2R device"],"prefix":"10.1186","volume":"8","author":[{"given":"Ingeborg","family":"Hospach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Harenski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Laffey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Pouchoulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Raible","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Votteler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Storr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,13]]},"reference":[{"key":"301_CR1","first-page":"232","volume":"13","author":"A Baker","year":"2012","unstructured":"Baker A, Richardson D, Craig G (2012) Extracorporeal carbon dioxide removal (ECCO2R) in respiratory failure: an overview, and where next? 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