{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:04:12Z","timestamp":1773399852511,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["ICMx"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Trauma-induced coagulopathy (TIC) is a life-threatening condition associated with high morbidity and mortality. TIC can present with different coagulation defects. In this study, the aim was to determine the effect of shock duration on TIC characteristics. We hypothesized that longer duration of shock leads to a more hypocoagulable rotational thromboelastometry (ROTEM) profile compared to a shorter duration of shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Male B57BL\/6J(c) mice (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095\u201310 per group) were sedated and mechanically ventilated. Trauma was induced by bilateral lower limb fractures and crush injuries to the liver and small intestine. Shock was induced by blood withdrawals until a mean arterial pressure of 25\u201330\u00a0mmHg was achieved. Groups reflected trauma and shock for 30\u00a0min (TS30) and trauma and shock for 90\u00a0min (TS90). Control groups included ventilation only (V90) and trauma only (T90).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mice in the TS90 group had significantly increased base deficit compared to the V90 group. Mortality was 10% in\u00a0the TS30\u00a0group and 30% in\u00a0the TS90\u00a0group. ROTEM profile was more hypocoagulable, as shown by significantly lower maximum clot firmness (MCF) in the TS30 group (43.5 [37.5\u201346.8] mm) compared to the TS90 group (52.0 [47.0\u201353.0] mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). ROTEM clotting time and parameters of clot build-up did not significantly differ between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TIC characteristics change with shock duration. Contrary to the hypothesis, a shorter duration of shock was associated with decreased maximum clotting amplitudes compared to\u00a0a longer duration of shock. The effect of shock duration on TIC should be further assessed in trauma patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40635-021-00428-1","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T19:04:17Z","timestamp":1641495857000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The effect of shock duration on trauma-induced coagulopathy in a murine model"],"prefix":"10.1186","volume":"10","author":[{"given":"Pieter H.","family":"Sloos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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NPJ is editor in Chief with Intensive Care Medicine Experimental. All other authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1"}}