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There remains uncertainty as to the optimal method\/timing of frailty assessment and the impact of care processes and adverse events on outcomes is unknown. We conducted a pilot study to inform on the conduct, design and feasibility of a multicenter study measuring frailty longitudinally during critical illness, care processes, occurrence of adverse events, and resultant outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Single-center pilot study enrolling patients over the age of 55 admitted to an Intensive Care Unit (ICU) for life-support interventions including mechanical ventilation, vasopressor therapy and\/or renal replacement therapy. Frailty was measured on ICU admission and hospital discharge with the Clinical Frailty Scale (CFS), the Frailty Index (FI) and CFS at 6-month follow-up. Frailty was defined as CFS\u2009\u2265\u20095 and a FI\u2009\u2265\u20090.20. Processes of care and adverse events were measured during their ICU and hospital stay including nutritional support, mobility, nosocomial infections and delirium. ICU, hospital and 6\u00a0months were determined.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In 49 patients enrolled, the mean (SD) age was 68.7\u2009\u00b1\u20097.9 with a 6-month mortality of 29%. Enrollment was 1 patient\/per week. Frailty was successfully measured at different time points during the patients stay\/follow-up and varied by method\/timing of assessment; by CFS and FI, respectively, in 17\/49 (36%), 23\/49 (47%) on admission, 22\/33 (67%), 21\/33 (63%) on hospital discharge and 11\/30 (37%) had a CFS\u2009\u2265\u20095 at 6\u00a0months. Processes of care and adverse events were readily captured during the ICU and ward stay with the exception of ward nutritional data. ICU, hospital outcomes and follow-up outcomes were worse in those who were frail irrespective of ascertainment method. Pre-existing frailty remained static in survivors, but progressed in non-frail survivors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>In this pilot study, we demonstrate that frailty measurement in critically ill patients over the course and recovery of their illness is feasible, that processes of care and adverse events are readily captured, have developed the tools and obtained data necessary for the planning and conduct of a large multicenter trial studying the interaction between frailty and critical illness.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40635-022-00446-7","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T23:03:45Z","timestamp":1654815825000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The frailty, outcomes, recovery and care steps of critically ill patients (FORECAST) study: pilot study results"],"prefix":"10.1186","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9027-7198","authenticated-orcid":false,"given":"John","family":"Muscedere","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Bagshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Sibley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Norman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl","family":"Rolfson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"446_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cger.2010.08.009","volume":"27","author":"QL Xue","year":"2011","unstructured":"Xue QL (2011) The frailty syndrome: definition and natural history. 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Consent was obtained from the patient if they were able to consent. If unable, consent was obtained from the substitute decision-maker. Consent for ongoing participation was obtained from patients regaining capacity.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"JM is the scientific director for the Canadian Frailty Network, which is a pan-Canadian not-for-profit network funded through the Networks of Centers of Excellence (NCE) program by the government of Canada<b>.<\/b>","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23"}}