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The primary aim of this study was to investigate oxygenation. Secondary aims were to assess respiratory and metabolic variables and lung tissue aeration.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Pigs were randomly assigned to FCV (<jats:italic>n<\/jats:italic>\u2009=\u20099) and PCV (<jats:italic>n<\/jats:italic>\u2009=\u20099). IAH was induced by insufflation of air into the abdomen to induce IAH grades ranging from 0 to 3. At each IAH grade FCV was undertaken using compliance guided pressure settings, or PCV (<jats:italic>n<\/jats:italic>\u2009=\u20099) was undertaken with the positive end-expiratory pressure titrated for maximum compliance and the peak pressure set to achieve a tidal volume of 7\u00a0ml\/kg. Gas exchange, ventilator settings and derived formulas were recorded at two timepoints for each grade of IAH. Lung aeration was assessed by a computed tomography scan at IAH grade 3.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All 18 pigs (median weight 54\u00a0kg [IQR 51\u201367]) completed the observation period of 4\u00a0h. Oxygenation was comparable at each IAH grade, but a significantly lower minute volume was required to secure normocapnia in FCV at all IAH grades (7.6 vs. 14.4, MD \u2212\u00a06.8 (95% CI \u2212\u00a08.5 to \u2212\u00a05.2) l\/min; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There was also a significant reduction of applied mechanical power being most evident at IAH grade 3 (25.9 vs. 57.6, MD \u2212\u00a031.7 (95% CI \u2212\u00a039.7 to \u2212\u00a023.7) J\/min; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Analysis of Hounsfield unit distribution of the computed tomography scans revealed a significant reduction in non- (5 vs. 8, MD \u2212\u00a03 (95% CI \u2212\u00a06 to 0) %; <jats:italic>p<\/jats:italic>\u2009=\u20090.032) and poorly-aerated lung tissue (7 vs. 15, MD \u2212\u00a06 (95% CI \u2212\u00a013 to \u2212\u00a03) %, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) for FCV. Concomitantly, normally-aerated lung tissue was significantly increased (84 vs. 76, MD 8 (95% CI 2 to 15) %; <jats:italic>p<\/jats:italic>\u2009=\u20090.011).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Individualised FCV showed similar oxygenation but required a significantly lower minute volume for CO<jats:sub>2<\/jats:sub>-removal, which led to a remarkable reduction of applied mechanical power. Additionally, there was a shift from non- and poorly-aerated lung tissue to normally-aerated lung tissue in FCV compared to PCV.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40635-024-00608-9","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T16:02:33Z","timestamp":1709827353000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Individualised flow-controlled ventilation reduces applied mechanical power and improves ventilation efficiency in a porcine intra-abdominal hypertension model"],"prefix":"10.1186","volume":"12","author":[{"given":"Julia","family":"Abram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1605-6696","authenticated-orcid":false,"given":"Patrick","family":"Spraider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Putzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Ranalter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Rinner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Katharina","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Glodny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Hell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Enk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Martini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"issue":"4","key":"608_CR1","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1097\/CCM.0000000000003623","volume":"47","author":"A Reintam Blaser","year":"2019","unstructured":"Reintam Blaser A, Regli A et al (2019) Incidence, risk factors, and outcomes of intra-abdominal hypertension in critically ill patients\u2014a prospective multicenter study (IROI study). 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PLoS Biol 18(7):e3000410. https:\/\/doi.org\/10.1371\/journal.pbio.3000410","journal-title":"PLoS Biol"}],"container-title":["Intensive Care Medicine Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40635-024-00608-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40635-024-00608-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40635-024-00608-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T16:05:34Z","timestamp":1709827534000},"score":1,"resource":{"primary":{"URL":"https:\/\/icm-experimental.springeropen.com\/articles\/10.1186\/s40635-024-00608-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["608"],"URL":"https:\/\/doi.org\/10.1186\/s40635-024-00608-9","relation":{},"ISSN":["2197-425X"],"issn-type":[{"value":"2197-425X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,7]]},"assertion":[{"value":"30 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Animal Care and Use Committee of the Medical University of Innsbruck and the Austrian Ministry of Science, Research and Economy (Protocol No.: BMBWF-V\/3b 2020-0.363.123). The study was carried out at the Experimental Research Unit of the Department of Anesthesia and Intensive Care Medicine at the Medical University of Innsbruck and was performed in accordance with EU regulations for animal experimentation (EU-Directive 2010\/63 of the European Parliament and the European Council); reporting is in accordance with current ARRIVE 2.0 guidelines [].","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"TB has patent applications on calculating and displaying dissipated energy and differentiating airway and tissue resistance. DE represents the inventor of EVA and FCV technology (Ventrain, Tritube, Evone), has royalties for EVA and FCV technology (Ventrain, Tritube, Evone), has patent applications on minimising dissipated energy and on calculating and displaying dissipated energy and differentiating airway and tissue resistance. All other authors have no conflicts of interest to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"27"}}