{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:43:27Z","timestamp":1792194207336,"version":"4.4.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100006751","name":"U.S. Army","doi-asserted-by":"publisher","award":["W81XWH-19-C-0101"],"award-info":[{"award-number":["W81XWH-19-C-0101"]}],"id":[{"id":"10.13039\/100006751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006751","name":"U.S. Army","doi-asserted-by":"publisher","award":["W81XWH-19-C-0083"],"award-info":[{"award-number":["W81XWH-19-C-0083"]}],"id":[{"id":"10.13039\/100006751","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["ICMx"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We tested the ability of a physiologically driven minimally invasive closed-loop algorithm, called Resuscitation based on Functional Hemodynamic Monitoring (ReFit), to stabilize for up to 3 h a porcine model of noncompressible hemorrhage induced by severe liver injury and do so during both ground and air transport. Twelve animals were resuscitated using ReFit to drive fluid and vasopressor infusion to a mean arterial pressure (MAP)\u2009&gt;\u200960 mmHg and heart rate\u2009&lt;\u2009110 min\n                    <jats:sup>\u22121<\/jats:sup>\n                    30 min after MAP\u2009&lt;\u200940 mmHg following liver injury. ReFit was initially validated in 8 animals in the laboratory, then in 4 animals during air (23nm and 35nm) and ground (9 mi) to air (9.5nm and 83m) transport returning to the laboratory. The ReFit algorithm kept all animals stable for\u2009~\u20093 h. Thus, ReFit algorithm can diagnose and treat ongoing hemorrhagic shock independent to the site of care or during transport. These results have implications for treatment of critically ill patients in remote, austere and contested environments and during transport to a higher level of care.\n                  <\/jats:p>","DOI":"10.1186\/s40635-024-00628-5","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:02:48Z","timestamp":1716490968000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Autonomous precision resuscitation during ground and air transport of an animal hemorrhagic shock model"],"prefix":"10.1186","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6166-700X","authenticated-orcid":false,"given":"Michael R.","family":"Pinsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernando","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis X.","family":"Guyette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Dubrawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"MacLachlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Lagattuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Salcido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Poropatich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"628_CR1","unstructured":"Army US(2020) Tactical Combat Casualty Care Handbook. LULU PRESS Incorporated."},{"key":"628_CR2","doi-asserted-by":"publisher","unstructured":"Poropatich RK, Pinsky MR (2020) Robotics enabled autonomous and closed loop trauma care in a rucksack - TRACIR. Healthcare 396. Transform (AI, Automation & Robot) https:\/\/doi.org\/10.1089\/heat.2019.0007","DOI":"10.1089\/heat.2019.0007"},{"key":"628_CR3","unstructured":"https:\/\/www.economist.com\/international\/2023\/08\/04\/what-ukraines-bloody-battlefield-is-teaching-medics"},{"key":"628_CR4","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1186\/cc3927","volume":"9","author":"MR Pinsky","year":"2005","unstructured":"Pinsky MR, Payen D (2005) Functional hemodynamic monitoring. 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Intensive Care Med 49:83\u201386","journal-title":"Intensive Care Med"},{"key":"628_CR12","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1186\/s13054-014-0626-6","volume":"18","author":"M Monge Garcia","year":"2014","unstructured":"Monge Garcia M et al (2014) Dynamic arterial elastance as a predictor of arterial pressure response to fluid administration: a validation study. Crit Care 18:626","journal-title":"Crit Care"}],"container-title":["Intensive Care Medicine Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40635-024-00628-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40635-024-00628-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40635-024-00628-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T17:15:03Z","timestamp":1732036503000},"score":1,"resource":{"primary":{"URL":"https:\/\/icm-experimental.springeropen.com\/articles\/10.1186\/s40635-024-00628-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,24]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["628"],"URL":"https:\/\/doi.org\/10.1186\/s40635-024-00628-5","relation":{},"ISSN":["2197-425X"],"issn-type":[{"value":"2197-425X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,24]]},"assertion":[{"value":"8 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Institutional Animal Care and Use Committee of the University of Pittsburgh (IACUC protocol No. IS00015990) for ethical validation of need, minimizing of pain and discomfort, selection of species, strain, number and sex of the animals, and Animal Care and Use Review Office (ACURO), a component of the USAMRDC Office of Research Protections (\n                      \n                      ).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Michael R. Pinsky, MD was a consultant to Baxter Medical, Edwards LifeSciences, and Masimo. All other authors claim no competing interests with regard to this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"44"}}