{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:03:48Z","timestamp":1787508228100,"version":"build-2736575974"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81960342"],"award-info":[{"award-number":["81960342"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100016039","name":"Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016039","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["ICMx"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis-induced acute lung injury (S-ALI) significantly contributes to unfavorable clinical outcomes. Emerging evidence suggests a novel role for ferroptosis in the pathophysiology of ALI, though the precise mechanisms remain unclear. Mild hypothermia (32\u201334\u00a0\u00b0C) has been shown to inhibit inflammatory responses, reduce oxidative stress, and regulate metabolic processes. P53 has been reported to downregulate the transcriptional activity of solute carrier family 7 member 11 (SLC7A11), thereby limiting cystine uptake. This reduction in cystine availability compromises the activity of Glutathione peroxidase 4\u00a0(GPX4), a cystine-dependent enzyme, ultimately increasing cellular susceptibility to ferroptosis. However, it remains unclear whether mild hypothermia exerts protective effects through the P53-SLC7A11\/GPX4 signaling pathway. This study investigates the influence of mild hypothermia on ferroptosis mediated by the P53-SLC7A11\/GPX4 pathway in S-ALI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study utilized both in vivo and in vitro models. In the vivo model, 64 Sprague\u2013Dawley rats were employed, with 40 analyzed for survival outcomes. Sepsis was induced using the cecum ligation and puncture (CLP) method, after which rats were subjected to either normothermic (36\u201338\u00a0\u00b0C) or mild hypothermic (32\u201334\u00a0\u00b0C) conditions for a duration of 10 h. Twelve hours post-surgery, blood samples, bronchoalveolar lavage fluid, and lung tissue samples were harvested for histological analysis, measurement of inflammatory markers, wet\/dry ratios, blood gas analysis, assessment of oxidative stress and ferroptosis, Western blotting, and RT-qPCR analysis. In the in vitro model, RLE-6TN cells were exposed to lipopolysaccharide (LPS) for 24 h under normothermic and mild hypothermic conditions. These cells were then evaluated for cell viability, inflammatory markers, oxidative stress levels, ferroptosis markers, as well as Western blot and RT-qPCR analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CLP-induced sepsis led to elevated levels of inflammatory markers, increased lung injury scores, and heightened oxidative stress markers. These detrimental effects were significantly ameliorated by mild hypothermia. Furthermore, mild hypothermia reversed the modified expression of P53, SLC7A11, and GPX4 signaling molecules. Notably, mild hypothermia also improved the 5-day survival rate of CLP rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mild hypothermia attenuates S-ALI and modulates ferroptosis through the P53-SLC7A11\/GPX4 signaling pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40635-025-00713-3","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T06:05:46Z","timestamp":1736921146000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Investigation into the influence of mild hypothermia on regulating ferroptosis through the P53-SLC7A11\/GPX4 signaling pathway in sepsis-induced acute lung injury"],"prefix":"10.1186","volume":"13","author":[{"given":"Liujun","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanhong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"713_CR1","doi-asserted-by":"publisher","first-page":"4073","DOI":"10.2147\/JIR.S420676","volume":"16","author":"Y Wang","year":"2023","unstructured":"Wang Y, Zhao Z, Xiao Z (2023) The emerging roles of ferroptosis in pathophysiology and treatment of acute lung injury. J Inflamm Res 16:4073\u20134085. https:\/\/doi.org\/10.2147\/JIR.S420676","journal-title":"J Inflamm Res"},{"key":"713_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108204","volume":"101","author":"AA Saied","year":"2021","unstructured":"Saied AA, El-Far AH, Narala VR, Ragab RF, Kovaleva EG (2021) Potential therapeutic interventions of plant\u2013derived isoflavones against acute lung injury. Int Immunopharmacol 101:108204. https:\/\/doi.org\/10.1016\/j.intimp.2021.108204","journal-title":"Int Immunopharmacol"},{"key":"713_CR3","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/s41419-022-04971-x","volume":"13","author":"YMY Yang","year":"2022","unstructured":"Yang YMY, Li Q, Ling Y, Zhou Y, Chu K (2022) STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53\/SLC7A11 pathway. Cell Death Dis 13:530. https:\/\/doi.org\/10.1038\/s41419-022-04971-x","journal-title":"Cell Death Dis"},{"key":"713_CR4","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M et al (2016) The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315:801\u2013810. https:\/\/doi.org\/10.1001\/jama.2016.0287","journal-title":"JAMA"},{"key":"713_CR5","doi-asserted-by":"publisher","first-page":"1800786","DOI":"10.1183\/13993003.00786-2018","volume":"53","author":"I Park","year":"2019","unstructured":"Park I, Kim M, Choe K, Song E, Seo H, Hwang Y et al (2019) Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injury. Eur Respir J 53:1800786. https:\/\/doi.org\/10.1183\/13993003.00786-2018","journal-title":"Eur Respir J"},{"key":"713_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103194","volume":"74","author":"D Wu","year":"2024","unstructured":"Wu D, Spencer CB, Ortoga L, Zhang H, Miao C (2024) Histone lactylation-regulated METTL3 promotes ferroptosis via m6A-modification on ACSL4 in sepsis-associated lung injury. Redox Biol 74:103194. https:\/\/doi.org\/10.1016\/j.redox.2024.103194","journal-title":"Redox Biol"},{"key":"713_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpsurg.2020.100777","volume":"57","author":"NT Mowery","year":"2020","unstructured":"Mowery NT, Hillman Terzian WT, Nelson AC (2020) Acute lung injury. Curr Probl Surg 57:100777. https:\/\/doi.org\/10.1016\/j.cpsurg.2020.100777","journal-title":"Curr Probl Surg"},{"key":"713_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-024-10503-z","author":"S Ma","year":"2024","unstructured":"Ma S, Song Y, Xu Y, Wang C, Yang Y, Zheng Y et al (2024) Mild therapeutic hypothermia alleviated myocardial ischemia\/reperfusion injury via targeting SLC25A10 to suppress mitochondrial apoptosis. J Cardiovasc Transl Res. https:\/\/doi.org\/10.1007\/s12265-024-10503-z","journal-title":"J Cardiovasc Transl Res"},{"key":"713_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0305213","volume":"19","author":"L Wei","year":"2024","unstructured":"Wei L, Wei K, Lu S, Wang M, Chen C, Huang H et al (2024) Mild hypothermia pretreatment improves hepatic ischemia\u2013reperfusion injury: a systematic review and meta-analysis of animal experiments. PLoS ONE 19:e0305213. https:\/\/doi.org\/10.1371\/journal.pone.0305213","journal-title":"PLoS ONE"},{"key":"713_CR10","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s40635-022-00481-4","volume":"10","author":"D Battaglini","year":"2022","unstructured":"Battaglini D, Da Silva AL, Felix NS, Rodrigues G, Antunes MA, Rocha NN et al (2022) Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke. Intensive Care Med Exp 10:53. https:\/\/doi.org\/10.1186\/s40635-022-00481-4","journal-title":"Intensive Care Med Exp"},{"key":"713_CR11","doi-asserted-by":"publisher","first-page":"9229","DOI":"10.3390\/ijms23169229","volume":"23","author":"M Schleef","year":"2022","unstructured":"Schleef M, Gonnot F, Pillot B, Leon C, Chanon S, Vieille-Marchiset A et al (2022) Mild therapeutic hypothermia protects from acute and chronic renal ischemia\u2013reperfusion injury in mice by mitigated mitochondrial dysfunction and modulation of local and systemic inflammation. Int J Mol Sci 23:9229. https:\/\/doi.org\/10.3390\/ijms23169229","journal-title":"Int J Mol Sci"},{"key":"713_CR12","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.brainresbull.2022.12.004","volume":"193","author":"Z Zhou","year":"2023","unstructured":"Zhou Z, Liu Z, Zhang C, Zhang W, Zhang C, Chen T et al (2023) Mild hypothermia alleviates early brain injury after subarachnoid hemorrhage via suppressing pyroptosis through AMPK\/NLRP3 inflammasome pathway in rats. Brain Res Bull 193:72\u201383. https:\/\/doi.org\/10.1016\/j.brainresbull.2022.12.004","journal-title":"Brain Res Bull"},{"key":"713_CR13","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/0300-9572(93)90178-S","volume":"26","author":"J Villar","year":"1993","unstructured":"Villar J, Slutsky AS (1993) Effects of induced hypothermia in patients with septic adult respiratory distress syndrome. Resuscitation 26:183\u2013192. https:\/\/doi.org\/10.1016\/0300-9572(93)90178-S","journal-title":"Resuscitation"},{"key":"713_CR14","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1159\/000493358","volume":"115","author":"M Hakobyan","year":"2019","unstructured":"Hakobyan M, Dijkman KP, Laroche S, Naulaers G, Rijken M, Steiner K et al (2019) Outcome of infants with therapeutic hypothermia after perinatal asphyxia and early-onset sepsis. Neonatology 115:127\u2013133. https:\/\/doi.org\/10.1159\/000493358","journal-title":"Neonatology"},{"key":"713_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lfs.2018.03.002","volume":"199","author":"W Ding","year":"2018","unstructured":"Ding W, Shen Y, Li Q, Jiang S, Shen H (2018) Therapeutic mild hypothermia improves early outcomes in rats subjected to severe sepsis. Life Sci 199:1\u20139. https:\/\/doi.org\/10.1016\/j.lfs.2018.03.002","journal-title":"Life Sci"},{"key":"713_CR16","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1089\/ther.2014.0024","volume":"5","author":"K L\u00e9on","year":"2015","unstructured":"L\u00e9on K, Pichavant-Rafini K, Ollivier H, Monbet V, L\u2019Her E (2015) Does induction time of mild hypothermia influence the survival duration of septic rats? Ther Hypothermia Temp Manag 5:85\u201388. https:\/\/doi.org\/10.1089\/ther.2014.0024","journal-title":"Ther Hypothermia Temp Manag"},{"key":"713_CR17","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.pediatrneurol.2017.04.023","volume":"74","author":"W Zhang","year":"2017","unstructured":"Zhang W, Ma J, Danzeng Q, Tang Y, Lu M, Kang Y (2017) Safety of moderate hypothermia for perinatal hypoxic-ischemic encephalopathy: a meta-analysis. Pediatr Neurol 74:51\u201361. https:\/\/doi.org\/10.1016\/j.pediatrneurol.2017.04.023","journal-title":"Pediatr Neurol"},{"key":"713_CR18","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006472","volume":"6","author":"JS Piktel","year":"2017","unstructured":"Piktel JS, Cheng A, McCauley M, Dale Z, Nassal M, Maleski D et al (2017) Hypothermia modulates arrhythmia substrates during different phases of resuscitation from ischemic cardiac arrest. J Am Heart Assoc Cardiovasc Cerebrovasc Dis 6:e006472. https:\/\/doi.org\/10.1161\/JAHA.117.006472","journal-title":"J Am Heart Assoc Cardiovasc Cerebrovasc Dis"},{"key":"713_CR19","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S2213-2600(18)30004-3","volume":"6","author":"TS Itenov","year":"2018","unstructured":"Itenov TS, Johansen ME, Bestle M, Thormar K, Hein L, Gyldensted L et al (2018) Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial. Lancet Respir Med 6:183\u2013192. https:\/\/doi.org\/10.1016\/S2213-2600(18)30004-3","journal-title":"Lancet Respir Med"},{"key":"713_CR20","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","volume":"18","author":"X Chen","year":"2021","unstructured":"Chen X, Kang R, Kroemer G, Tang Dl (2021) Broadening horizons: the role of ferroptosis in cancer. Clin Oncol 18:280\u2013296. https:\/\/doi.org\/10.1038\/s41571-020-00462-0","journal-title":"Clin Oncol"},{"key":"713_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2023.110698","volume":"108","author":"S Wang","year":"2023","unstructured":"Wang S, Song Y, Xu F, Liu H, Shen Y, Hu L (2023) Identification and validation of ferroptosis-related genes in lipopolysaccharide-induced acute lung injury. Cell Signal 108:110698. https:\/\/doi.org\/10.1016\/j.cellsig.2023.110698","journal-title":"Cell Signal"},{"key":"713_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.956361","volume":"13","author":"L Xl","year":"2022","unstructured":"Xl L, Gy Z, GuoCui RN (2022) Ferroptosis in sepsis: the mechanism, the role and the therapeutic potential. Front Immunol 13:956361. https:\/\/doi.org\/10.3389\/fimmu.2022.956361","journal-title":"Front Immunol"},{"key":"713_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.903859","volume":"13","author":"J Shimizu","year":"2022","unstructured":"Shimizu J, Murao A, Nofi C, Wang P, Aziz M (2022) Extracellular CIRP promotes GPX4-mediated ferroptosis in sepsis. Front Immunol 13:903859. https:\/\/doi.org\/10.3389\/fimmu.2022.903859","journal-title":"Front Immunol"},{"key":"713_CR24","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s11658-020-00205-0","volume":"25","author":"P Liu","year":"2020","unstructured":"Liu P, Feng Y, Li H, Chen X, Wang G, Xu S et al (2020) Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis. Cell Mol Biol Lett 25:10. https:\/\/doi.org\/10.1186\/s11658-020-00205-0","journal-title":"Cell Mol Biol Lett"},{"key":"713_CR25","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s11658-022-00318-8","volume":"27","author":"J Li","year":"2022","unstructured":"Li J, Deng S, Li J, Li L, Zhang F, Zou Y et al (2022) Obacunone alleviates ferroptosis during lipopolysaccharide-induced acute lung injury by upregulating Nrf2-dependent antioxidant responses. Cell Mol Biol Lett 27:29. https:\/\/doi.org\/10.1186\/s11658-022-00318-8","journal-title":"Cell Mol Biol Lett"},{"key":"713_CR26","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.freeradbiomed.2024.08.001","volume":"223","author":"W Jiang","year":"2024","unstructured":"Jiang W, Yu L, Mu N, Zhang Z, Ma H (2024) MG53 inhibits ferroptosis by targeting the p53\/SLC7A11\/GPX4 pathway to alleviate doxorubicin-induced cardiotoxicity. Free Radic Biol Med 223:224\u2013236. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2024.08.001","journal-title":"Free Radic Biol Med"},{"key":"713_CR27","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000002224","author":"H Chen","year":"2023","unstructured":"Chen H, Xie W, Peng Z, Liu Y, Li H, Huang W (2023) Nobiletin ameliorates heatstroke-induced acute lung injury by inhibiting ferroptosis via p53\/SLC7A11 pathway. Shock. https:\/\/doi.org\/10.1097\/SHK.0000000000002224","journal-title":"Shock"},{"key":"713_CR28","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/s41419-022-04924-4","volume":"13","author":"M Yang","year":"2022","unstructured":"Yang M (2022) Involvement of FSP1-CoQ10-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis. Cell Death Dis 13:468. https:\/\/doi.org\/10.1038\/s41419-022-04924-4","journal-title":"Cell Death Dis"},{"key":"713_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108002","volume":"99","author":"Y Gao","year":"2021","unstructured":"Gao Y, Li J, Wu Q, Wang S, Yang S, Li X et al (2021) Tetrahydroxy stilbene glycoside ameliorates Alzheimer\u2019s disease in APP\/PS1 mice via glutathione peroxidase related ferroptosis. Int Immunopharmacol 99:108002. https:\/\/doi.org\/10.1016\/j.intimp.2021.108002","journal-title":"Int Immunopharmacol"},{"key":"713_CR30","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1097\/MAO.0000000000004271","volume":"45","author":"Y Li","year":"2024","unstructured":"Li Y, Xu H, Shi J, Li C, Li M, Zhang X et al (2024) Regulation of the p53\/SLC7A11\/GPX4 pathway by gentamicin induces ferroptosis in HEI-OC1 cells. Otol Neurotol 45:947\u2013953. https:\/\/doi.org\/10.1097\/MAO.0000000000004271","journal-title":"Otol Neurotol"},{"key":"713_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105305","volume":"164","author":"X Zhou","year":"2021","unstructured":"Zhou X, Zou L, Chen W, Yang T, Luo J, Wu K et al (2021) Flubendazole, FDA-approved anthelmintic, elicits valid antitumor effects by targeting P53 and promoting ferroptosis in castration-resistant prostate cancer. Pharmacol Res 164:105305. https:\/\/doi.org\/10.1016\/j.phrs.2020.105305","journal-title":"Pharmacol Res"},{"key":"713_CR32","doi-asserted-by":"publisher","first-page":"303","DOI":"10.4103\/0976-500X.119726","volume":"4","author":"J Charan","year":"2013","unstructured":"Charan J, Kantharia ND (2013) How to calculate sample size in animal studies? J Pharmacol Pharmacother 4:303\u2013306. https:\/\/doi.org\/10.4103\/0976-500X.119726","journal-title":"J Pharmacol Pharmacother"},{"key":"713_CR33","doi-asserted-by":"publisher","first-page":"5641","DOI":"10.3390\/ijms24065641","volume":"24","author":"J-Y Cho","year":"2023","unstructured":"Cho J-Y, Kim S-J, Woo C-G, Kwon S-K, Choe K-H, Kim E-G et al (2023) Altered lung heat shock protein-70 expression and severity of sepsis-induced acute lung injury in a chronic kidney disease rat model. Int J Mol Sci 24:5641. https:\/\/doi.org\/10.3390\/ijms24065641","journal-title":"Int J Mol Sci"},{"key":"713_CR34","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nprot.2008.214","volume":"4","author":"D Rittirsch","year":"2009","unstructured":"Rittirsch D, Huber-Lang MS, Flierl MA, Ward PA (2009) Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc 4:31\u201336. https:\/\/doi.org\/10.1038\/nprot.2008.214","journal-title":"Nat Protoc"},{"key":"713_CR35","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1165\/rcmb.2021-0531ST","volume":"66","author":"HS Kulkarni","year":"2022","unstructured":"Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM et al (2022) Update on the features and measurements of experimental acute lung injury in animals: an official American thoracic society workshop report. Am J Respir Cell Mol Biol 66:e1\u2013e14. https:\/\/doi.org\/10.1165\/rcmb.2021-0531ST","journal-title":"Am J Respir Cell Mol Biol"},{"key":"713_CR36","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-233","author":"B Shrum","year":"2014","unstructured":"Shrum B, Anantha RV, Xu SX, Donnelly M, Haeryfar SM, McCormick JK et al (2014) A robust scoring system to evaluate sepsis severity in an animal model. BMC Res Notes. https:\/\/doi.org\/10.1186\/1756-0500-7-233","journal-title":"BMC Res Notes"},{"key":"713_CR37","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","volume":"12","author":"P Koppula","year":"2021","unstructured":"Koppula P, Zhuang L, Gan B (2021) Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell 12:599\u2013620. https:\/\/doi.org\/10.1007\/s13238-020-00789-5","journal-title":"Protein Cell"},{"key":"713_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2023.113644","volume":"174","author":"Z Gong","year":"2023","unstructured":"Gong Z, Wang Y, Li L, Li X, Qiu B, Hu Y (2023) Cardamonin alleviates chondrocytes inflammation and cartilage degradation of osteoarthritis by inhibiting ferroptosis via p53 pathway. Food Chem Toxicol 174:113644. https:\/\/doi.org\/10.1016\/j.fct.2023.113644","journal-title":"Food Chem Toxicol"},{"key":"713_CR39","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.molimm.2021.12.003","volume":"141","author":"J Li","year":"2022","unstructured":"Li J, Li M, Li L, Ma J, Yao C, Yao S (2022) Hydrogen sulfide attenuates ferroptosis and stimulates autophagy by blocking mTOR signaling in sepsis-induced acute lung injury. Mol Immunol 141:318\u2013327. https:\/\/doi.org\/10.1016\/j.molimm.2021.12.003","journal-title":"Mol Immunol"},{"key":"713_CR40","doi-asserted-by":"publisher","first-page":"5093","DOI":"10.3390\/ijms24065093","volume":"24","author":"K Lai","year":"2023","unstructured":"Lai K, Song C, Gao M, Deng Y, Lu Z, Li N et al (2023) Uridine alleviates sepsis-induced acute lung injury by inhibiting ferroptosis of macrophage. Int J Mol Sci 24:5093. https:\/\/doi.org\/10.3390\/ijms24065093","journal-title":"Int J Mol Sci"},{"key":"713_CR41","doi-asserted-by":"publisher","first-page":"300","DOI":"10.3390\/antiox13030300","volume":"13","author":"Z Zhu","year":"2024","unstructured":"Zhu Z, Chambers S, Bhatia M (2024) Suppressing the substance P-NK1R signalling protects mice against sepsis-associated acute inflammatory injury and ferroptosis in the liver and lungs. Antioxidants 13:300. https:\/\/doi.org\/10.3390\/antiox13030300","journal-title":"Antioxidants"},{"key":"713_CR42","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060\u20131072. https:\/\/doi.org\/10.1016\/j.cell.2012.03.042","journal-title":"Cell"},{"key":"713_CR43","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.16748","volume":"12","author":"T Wang","year":"2024","unstructured":"Wang T, Zhang Z, Deng Z, Zeng W, Gao Y, Hei Z et al (2024) Mesenchymal stem cells alleviate sepsis-induced acute lung injury by blocking neutrophil extracellular traps formation and inhibiting ferroptosis in rats. PeerJ 12:e16748. https:\/\/doi.org\/10.7717\/peerj.16748","journal-title":"PeerJ"},{"key":"713_CR44","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12967-021-02745-1","volume":"19","author":"J Li","year":"2021","unstructured":"Li J, Lu K, Sun F, Tan S, Zhang X, Sheng W et al (2021) Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2\/HO-1 pathway. J Transl Med 19:96. https:\/\/doi.org\/10.1186\/s12967-021-02745-1","journal-title":"J Transl Med"},{"key":"713_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102317","volume":"52","author":"S Ouyang","year":"2022","unstructured":"Ouyang S (2022) Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biol 52:102317. https:\/\/doi.org\/10.1016\/j.redox.2022.102317","journal-title":"Redox Biol"},{"key":"713_CR46","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22:266\u2013282. https:\/\/doi.org\/10.1038\/s41580-020-00324-8","journal-title":"Nat Rev Mol Cell Biol"},{"key":"713_CR47","doi-asserted-by":"publisher","unstructured":"Yang MX. Remifentanil reduces multiple organ and energy metabolism disturbances in a rat sepsis model. J Physiol Pharmacol. 2022;73(1). https:\/\/doi.org\/10.26402\/jpp.2022.1.08.","DOI":"10.26402\/jpp.2022.1.08"},{"key":"713_CR48","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1186\/s12964-022-00994-1","volume":"20","author":"B Guo","year":"2022","unstructured":"Guo B, Zuo Z, Di X, Huang Y, Gong G, Xu B et al (2022) Salidroside attenuates HALI via IL-17A-mediated ferroptosis of alveolar epithelial cells by regulating Act1-TRAF6-p38 MAPK pathway. Cell Commun Signal CCS 20:183. https:\/\/doi.org\/10.1186\/s12964-022-00994-1","journal-title":"Cell Commun Signal CCS"},{"key":"713_CR49","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1186\/s12903-024-04395-3","volume":"24","author":"C Mao","year":"2024","unstructured":"Mao C, Gong L, Kang W (2024) Effect and mechanism of resveratrol on ferroptosis mediated by p53\/SLC7A11 in oral squamous cell carcinoma. BMC Oral Health 24:773. https:\/\/doi.org\/10.1186\/s12903-024-04395-3","journal-title":"BMC Oral Health"},{"key":"713_CR50","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.bbrc.2021.06.036","volume":"27","author":"Y Shi","year":"2021","unstructured":"Shi Y (2021) Tirapazamine suppress osteosarcoma cells in part through SLC7A11 mediated ferroptosis. Biochem Biophys Res Commun 27:118\u2013124. https:\/\/doi.org\/10.1016\/j.bbrc.2021.06.036","journal-title":"Biochem Biophys Res Commun"},{"key":"713_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/1783485","volume":"2021","author":"Y Luo","year":"2021","unstructured":"Luo Y, Gao X, Zou L, Lei M, Feng J, Hu Z (2021) Bavachin induces ferroptosis through the STAT3\/P53\/SLC7A11 axis in osteosarcoma cells. Oxid Med Cell Longev 2021:1\u201314. https:\/\/doi.org\/10.1155\/2021\/1783485","journal-title":"Oxid Med Cell Longev"},{"key":"713_CR52","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-024-4104-y","author":"D He","year":"2024","unstructured":"He D, Tan X, Li L, Gao W, Tian X, Zeng P (2024) Brazilin actuates ferroptosis in breast cancer cells via p53\/SLC7A11\/GPX4 signaling pathway. Chin J Integr Med. https:\/\/doi.org\/10.1007\/s11655-024-4104-y","journal-title":"Chin J Integr Med"},{"key":"713_CR53","doi-asserted-by":"publisher","first-page":"3644","DOI":"10.1038\/s41467-021-23902-6","volume":"12","author":"D Chen","year":"2021","unstructured":"Chen D, Chu B, Yang X, Liu Z, Jin Y, Kon N et al (2021) iPLA2\u03b2-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4. Nat Commun 12:3644. https:\/\/doi.org\/10.1038\/s41467-021-23902-6","journal-title":"Nat Commun"},{"key":"713_CR54","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/s41418-022-00943-y","volume":"29","author":"Y Liu","year":"2022","unstructured":"Liu Y, Gu W (2022) p53 in ferroptosis regulation: the new weapon for the old guardian. Cell Death Differ 29:895\u2013910. https:\/\/doi.org\/10.1038\/s41418-022-00943-y","journal-title":"Cell Death Differ"},{"key":"713_CR55","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.arcmed.2022.11.005","volume":"54","author":"L Jiang","year":"2023","unstructured":"Jiang L, Li X, Hu J, Tang Z (2023) Mild hypothermia alleviates CLP-induced multiple organ dysfunction by mitigating pyroptosis through the TLR4\/NF-\u03baB\/NLRP3 signaling pathway. Arch Med Res 54:7\u201316. https:\/\/doi.org\/10.1016\/j.arcmed.2022.11.005","journal-title":"Arch Med Res"}],"container-title":["Intensive Care Medicine Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40635-025-00713-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40635-025-00713-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40635-025-00713-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T06:05:50Z","timestamp":1736921150000},"score":1,"resource":{"primary":{"URL":"https:\/\/icm-experimental.springeropen.com\/articles\/10.1186\/s40635-025-00713-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,15]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["713"],"URL":"https:\/\/doi.org\/10.1186\/s40635-025-00713-3","relation":{},"ISSN":["2197-425X"],"issn-type":[{"value":"2197-425X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,15]]},"assertion":[{"value":"12 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee for the Use of Animals Approval No. 202306672) of Guangxi Medical University, China.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4"}}