{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T03:21:46Z","timestamp":1775186506641,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["ICMx"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute respiratory distress syndrome (ARDS) remains associated with high mortality and ventilator-induced lung injury. Continuous-flow ventilation (CFV) may reduce cyclic strain, but faced technical limitations. VENTIJET is a novel nozzle-based CFV ventilator designed for safe use in critically ill adults. This pilot study evaluated its feasibility and safety in patients with moderate ARDS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective, single-center pilot safety and feasibility study in intubated adults with moderate ARDS and stable oxygenation. After a 1-h baseline period with volume-controlled ventilation (Puritan Bennett\u2122 840), patients received up to 24\u00a0h of VENTIJET ventilation, then returned to conventional ventilation. Primary endpoints were feasibility and safety; secondary exploratory endpoints included gas exchange and respiratory mechanics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fourteen patients were enrolled. VENTIJET ventilation was successfully delivered in all participants without protocol interruptions or device-related serious adverse events. After 1\u00a0h, PaO\u2082\/FiO\u2082 was 200\u00a0mm Hg compared to 192\u00a0mm Hg at baseline (p\u2009=\u20090.090). Over 24\u00a0h, oxygenation and respiratory system compliance showed modest improvement, with stable carbon dioxide (CO\u2082) elimination, transpulmonary pressures, and hemodynamics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with moderate ARDS, VENTIJET CFV was feasible and safe, maintaining stable gas exchange with modest improvements in respiratory mechanics. These findings support further evaluation in larger, controlled trials, including the full spectrum of ARDS.<\/jats:p>\n                    <jats:p>\n                      <jats:italic>Trial registration<\/jats:italic>\n                      ClinicalTrials.gov Identifier NCT07121257.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40635-026-00876-7","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T02:28:21Z","timestamp":1775183301000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Continuous-flow ventilation with VENTIJET in moderate ARDS: a pilot safety and feasibility study"],"prefix":"10.1186","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct07121257","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Luc\u00eda","family":"Picazo Moreno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Castellv\u00ed-Font","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Acer Puig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carles","family":"Cama\u00f1es Mayordomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Soriano Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan Ramon","family":"Masclans Enviz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-2759","authenticated-orcid":false,"given":"Francisco Jos\u00e9","family":"Parrilla-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"876_CR1","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1001\/jama.2016.0291","volume":"315","author":"G Bellani","year":"2016","unstructured":"Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson BT, Wrigge H, Slutsky AS, Pesenti A (2016) Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. 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The study was registered retrospectively on ClinicalTrials.gov (NCT07121257) to ensure transparent international reporting of the results. Written informed consent was obtained from the patients or their legal surrogates prior to inclusion\n                      \n                        .\n                      \n                      The study was externally monitored by the Clinical Research Support Unit (SEIC) of Biocruces Bizkaia, Spain, to ensure Good Clinical Practice compliance.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All patients or their immediate family members gave their consent for the dissemination of the results derived from the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Luc\u00eda Picazo Moreno and Francisco Jos\u00e9 Parrilla G\u00f3mez are co-inventors of the Ventijet ventilator, protected under Spanish Patent No. ES2926416, granted by the Spanish Patent and Trademark Office (OEPM), and co-founders of Ventijet Healthcare, a company established for research and development purposes. This intellectual property is not currently commercialized. Francisco Jos\u00e9 Parrilla G\u00f3mez declares personal fees for occasional lectures to Vantive\u00ae and Estor\u00ae. Joan Ramon Masclans Enviz declares grants and non-financial support from Fisher & Paykel, personal fees from Gilead and Aerogen, and Member of the Aerogen European Medical Advisory Board. All other authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"42"}}