{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:00:31Z","timestamp":1780560031094,"version":"3.54.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["ICMx"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Guidelines on neonatal resuscitation recommend 90 chest compressions (CCs) and 30 ventilations (3:1 C:V) per minute in newborns. We have described an alternative resuscitation strategy where CCs are superimposed with sustained inflation (CC\u2009+\u2009SI), which allows for passive ventilation during compression. A more recent strategy is CCs with synchronized ventilation (CCSV), in which a ventilator flow sensor recognizes airflow during the downward phase of compression and thereby triggers an inflation. No study has compared CCSV with CC\u2009+\u2009SI in an asphyxiated newborn piglet model. Newborn piglets (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098\/group) were anesthetized, intubated, instrumented, and exposed to 45\u00a0min of normocapnic hypoxia, followed by asphyxia and asystolic cardiac arrest. Piglets were randomized to CCSV or CC\u2009+\u2009SI. Hemodynamic and respiratory parameters were continuously measured.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen neonatal mixed-breed piglets (1\u20133\u00a0days of age, weighing 1.7\u20132.8\u00a0kg) were randomized to CCSV or CC\u2009+\u2009SI. Median (IQR) time to ROSC was 68 (50\u2013125) s with CCSV and 71 (60\u2013178) s with CC\u2009+\u2009SI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.537). The rate of ROSC with CCSV compared to CC\u2009+\u2009SI was 6\/8 (75%) vs. 5\/8 (63%), respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.000. CCSV had significantly higher peak inflation pressure (45 vs. 36 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O) and lower positive end-expiratory pressure (5.3 vs. 37 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O) compared to CC\u2009+\u2009SI (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); tidal volumes were not significantly different.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Use of CCSV did not result in a faster time to ROSC compared to CC\u2009+\u2009SI, and survival rates and physiological stability did not differ significantly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40635-026-00920-6","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:07:00Z","timestamp":1780556820000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chest compression synchronized ventilation versus chest compression superimposed by sustained inflation in asphyxiated newborn piglets: a randomized animal trial"],"prefix":"10.1186","volume":"14","author":[{"given":"Raza","family":"Hyderi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrieya","family":"Praveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"O\u2019Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Ramsie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze-Fun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-2415","authenticated-orcid":false,"given":"Georg M.","family":"Schm\u00f6lzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"920_CR1","doi-asserted-by":"publisher","first-page":"S524","DOI":"10.1161\/cir.0000000000000902","volume":"142","author":"K Aziz","year":"2020","unstructured":"Aziz K, Lee HC, Escobedo MB, Hoover AV, Kamath-Rayne BD, Kapadia VS et al (2020) Part 5: Neonatal resuscitation: 2020 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 142:S524\u2013S550. https:\/\/doi.org\/10.1161\/cir.0000000000000902","journal-title":"Circulation"},{"key":"920_CR2","doi-asserted-by":"publisher","first-page":"S185","DOI":"10.1161\/cir.0000000000000895","volume":"142","author":"MH Wyckoff","year":"2020","unstructured":"Wyckoff MH, Wyllie J, Aziz K, de Almeida MF, Fabres J, Fawke J et al (2020) Neonatal life support: 2020 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Circulation 142:S185-221. https:\/\/doi.org\/10.1161\/cir.0000000000000895","journal-title":"Circulation"},{"key":"920_CR3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1159\/000487988","volume":"114","author":"MP Pasquin","year":"2018","unstructured":"Pasquin MP, Cheung P-Y, Patel S, Lu M, Lee T-F, Wagner M et al (2018) Comparison of different compression to ventilation ratios (2: 1, 3: 1, and 4: 1) during cardiopulmonary resuscitation in a porcine model of neonatal asphyxia. Neonatology 114:37\u201345. https:\/\/doi.org\/10.1159\/000487988","journal-title":"Neonatology"},{"key":"920_CR4","doi-asserted-by":"publisher","first-page":"F417","DOI":"10.1136\/adc.2010.200386","volume":"96","author":"AL Solev\u00e5g","year":"2011","unstructured":"Solev\u00e5g AL, Dannevig I, Wyckoff M, Saugstad OD, Nakstad B (2011) Return of spontaneous circulation with a compression:ventilation ratio of 15:2 versus 3:1 in newborn pigs with cardiac arrest due to asphyxia. Arch Dis Child Fetal Neonatal Ed 96:F417. https:\/\/doi.org\/10.1136\/adc.2010.200386","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"920_CR5","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1016\/j.resuscitation.2010.06.007","volume":"81","author":"A Solev\u00e5g","year":"2010","unstructured":"Solev\u00e5g A, Dannevig I, Wyckoff MH, Saugstad OD, Nakstad B (2010) Extended series of cardiac compressions during CPR in a swine model of perinatal asphyxia. Resuscitation 81:1571\u20131576. https:\/\/doi.org\/10.1016\/j.resuscitation.2010.06.007","journal-title":"Resuscitation"},{"key":"920_CR6","doi-asserted-by":"publisher","first-page":"F530","DOI":"10.1136\/archdischild-2015-308363","volume":"100","author":"ES Li","year":"2015","unstructured":"Li ES, Cheung P-Y, O\u2019Reilly M, Schm\u00f6lzer GM (2015) Change in tidal volume during cardiopulmonary resuscitation in newborn piglets. Arch Dis Child Fetal Neonatal Ed 100:F530\u2013F533. https:\/\/doi.org\/10.1136\/archdischild-2015-308363","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"920_CR7","doi-asserted-by":"publisher","first-page":"110511","DOI":"10.1016\/j.resuscitation.2025.110511","volume":"207","author":"N Segond","year":"2025","unstructured":"Segond N, Wittig J, Kern WJ, Orlob S (2025) Towards a common terminology of ventilation during cardiopulmonary resuscitation. Resuscitation 207:110511. https:\/\/doi.org\/10.1016\/j.resuscitation.2025.110511","journal-title":"Resuscitation"},{"key":"920_CR8","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.resuscitation.2020.10.007","volume":"158","author":"C Halling","year":"2021","unstructured":"Halling C, Raymond T, Brown LS, Ades A, Foglia EE, Allen E et al (2021) Neonatal delivery room CPR: an analysis of the Get with the Guidelines\u00ae\u2014Resuscitation Registry. Resuscitation 158:236\u2013242. https:\/\/doi.org\/10.1016\/j.resuscitation.2020.10.007","journal-title":"Resuscitation"},{"key":"920_CR9","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.resuscitation.2016.10.012","volume":"110","author":"EE Foglia","year":"2017","unstructured":"Foglia EE, Langeveld R, Heimall L, Deveney A, Ades A, Jensen EA et al (2017) Incidence, characteristics, and survival following cardiopulmonary resuscitation in the quaternary neonatal intensive care unit. Resuscitation 110:32\u201336. https:\/\/doi.org\/10.1016\/j.resuscitation.2016.10.012","journal-title":"Resuscitation"},{"key":"920_CR10","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.resuscitation.2013.10.016","volume":"85","author":"AS Soraisham","year":"2014","unstructured":"Soraisham AS, Lodha AK, Singhal N, Aziz K, Yang J, Lee SK et al (2014) Neonatal outcomes following extensive cardiopulmonary resuscitation in the delivery room for infants born at less than 33 weeks gestational age. Resuscitation 85:238\u2013243. https:\/\/doi.org\/10.1016\/j.resuscitation.2013.10.016","journal-title":"Resuscitation"},{"key":"920_CR11","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/jp.2009.70","volume":"29","author":"PS Shah","year":"2009","unstructured":"Shah PS, Shah P, Tai KFY (2009) Chest compression and\/or epinephrine at birth for preterm infants &lt;32 weeks gestational age: matched cohort study of neonatal outcomes. J Perinatol 29:693\u2013697. https:\/\/doi.org\/10.1038\/jp.2009.70","journal-title":"J Perinatol"},{"key":"920_CR12","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1161\/circulationaha.113.002289","volume":"128","author":"GM Schm\u00f6lzer","year":"2013","unstructured":"Schm\u00f6lzer GM, O\u2019Reilly M, LaBossiere J, Lee T-F, Cowan S, Qin S et al (2013) Cardiopulmonary resuscitation with chest compressions during sustained inflations. Circulation 128:2495\u20132503. https:\/\/doi.org\/10.1161\/circulationaha.113.002289","journal-title":"Circulation"},{"key":"920_CR13","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jacbts.2018.12.004","volume":"4","author":"GM Schm\u00f6lzer","year":"2019","unstructured":"Schm\u00f6lzer GM (2019) Chest compressions during sustained inflation during cardiopulmonary resuscitation in newborn infants translating evidence from animal studies to the bedside. JACC Basic Transl Sci 4:116\u2013121. https:\/\/doi.org\/10.1016\/j.jacbts.2018.12.004","journal-title":"JACC Basic Transl Sci"},{"key":"920_CR14","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2023-326769","author":"J Koo","year":"2024","unstructured":"Koo J, Cheung P-Y, Pichler G, Solev\u00e5g AL, Law BHY, Katheria AC et al (2024) Chest compressions superimposed with sustained inflation during neonatal cardiopulmonary resuscitation: are we ready for a clinical trial? Arch Dis Child Fetal Neonatal Ed. https:\/\/doi.org\/10.1136\/archdischild-2023-326769","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"920_CR15","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3390\/children12020230","volume":"12","author":"J Koo","year":"2025","unstructured":"Koo J, Katheria AC, Law B, Solev\u00e5g AL, Pichler G, Schm\u00f6lzer GM (2025) Chest compression superimposed with sustained inflation or 3:1 compression\/ventilation ratio during neonatal cardiopulmonary resuscitation in the delivery room: a systematic review and meta-analysis. Children 12:230. https:\/\/doi.org\/10.3390\/children12020230","journal-title":"Children"},{"key":"920_CR16","doi-asserted-by":"publisher","first-page":"F455","DOI":"10.1136\/archdischild-2017-313037","volume":"103","author":"GM Schm\u00f6lzer","year":"2018","unstructured":"Schm\u00f6lzer GM, Reilly MO, Fray C, van Os S, Cheung P-Y (2018) Chest compression during sustained inflation versus 3:1 chest compression:ventilation ratio during neonatal cardiopulmonary resuscitation: a randomised feasibility trial. Arch Dis Child Fetal Neonatal Ed 103:F455\u2013F460. https:\/\/doi.org\/10.1136\/archdischild-2017-313037","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"920_CR17","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2023-326383","author":"GM Schm\u00f6lzer","year":"2024","unstructured":"Schm\u00f6lzer GM, Pichler G, Solev\u00e5g AL, Law BHY, Mitra S, Wagner M et al (2024) Sustained inflation and chest compression versus 3:1 chest compression to ventilation ratio during cardiopulmonary resuscitation of asphyxiated newborns (SURV1VE): a cluster randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. https:\/\/doi.org\/10.1136\/archdischild-2023-326383","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"920_CR18","doi-asserted-by":"publisher","first-page":"e0127759","DOI":"10.1371\/journal.pone.0127759","volume":"10","author":"C Kill","year":"2015","unstructured":"Kill C, Galbas M, Neuhaus C, Hahn O, Wallot P, Kesper K et al (2015) Chest compression synchronized ventilation versus intermitted positive pressure ventilation during cardiopulmonary resuscitation in a pig model. PLoS ONE 10:e0127759. https:\/\/doi.org\/10.1371\/journal.pone.0127759","journal-title":"PLoS ONE"},{"key":"920_CR19","doi-asserted-by":"publisher","first-page":"e89","DOI":"10.1097\/ccm.0b013e3182a63fa0","volume":"42","author":"C Kill","year":"2013","unstructured":"Kill C, Hahn O, Dietz F, Neuhaus C, Schwarz S, Mahling R et al (2013) Mechanical ventilation during cardiopulmonary resuscitation with intermittent positive-pressure ventilation, bilevel ventilation, or chest compression synchronized ventilation in a pig model&ast. Crit Care Med 42:e89-95. https:\/\/doi.org\/10.1097\/ccm.0b013e3182a63fa0","journal-title":"Crit Care Med"},{"key":"920_CR20","doi-asserted-by":"publisher","first-page":"100918","DOI":"10.1016\/j.resplu.2025.100918","volume":"22","author":"J Kopra","year":"2025","unstructured":"Kopra J, Mehtonen L, Laitinen M, Litonius E, Arvola O, \u00d6stman R et al (2025) Chest compression synchronized ventilation during prolonged experimental cardiopulmonary resuscitation improves oxygenation but may cause pneumothoraces. Resusc Plus 22:100918. https:\/\/doi.org\/10.1016\/j.resplu.2025.100918","journal-title":"Resusc Plus"},{"key":"920_CR21","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.3390\/jcm14072394","volume":"14","author":"YT Oh","year":"2025","unstructured":"Oh YT, Lee CA, Park HA, Park J, Kim S, Park HJ et al (2025) Effectiveness of chest compression-synchronized ventilation in patients with cardiac arrest. J Clin Med 14:2394. https:\/\/doi.org\/10.3390\/jcm14072394","journal-title":"J Clin Med"},{"key":"920_CR22","doi-asserted-by":"publisher","first-page":"1057000","DOI":"10.3389\/fmed.2022.1057000","volume":"9","author":"J Xu","year":"2022","unstructured":"Xu J, Khan ZU, Zhang M, Wang J, Zhou M, Zheng Z et al (2022) The combination of chest compression synchronized ventilation and aortic balloon occlusion improve the outcomes of cardiopulmonary resuscitation in swine. Front Med 9:1057000. https:\/\/doi.org\/10.3389\/fmed.2022.1057000","journal-title":"Front Med"},{"key":"920_CR23","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1113\/ep088870","volume":"105","author":"NP du Sert","year":"2020","unstructured":"du Sert NP, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M et al (2020) The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. Exp Physiol 105:1459\u20131466. https:\/\/doi.org\/10.1113\/ep088870","journal-title":"Exp Physiol"},{"key":"920_CR24","doi-asserted-by":"publisher","DOI":"10.3791\/3166","author":"P-Y Cheung","year":"2011","unstructured":"Cheung P-Y, Gill RS, Bigam DL (2011) A swine model of neonatal asphyxia. J Vis Exp. https:\/\/doi.org\/10.3791\/3166","journal-title":"J Vis Exp"},{"key":"920_CR25","doi-asserted-by":"publisher","first-page":"F295","DOI":"10.1136\/adc.2009.165878","volume":"95","author":"GM Schm\u00f6lzer","year":"2010","unstructured":"Schm\u00f6lzer GM, Kamlin OCOF, Dawson JA, te Pas AB, Morley CJ, Davis PG (2010) Respiratory monitoring of neonatal resuscitation. Arch Dis Child Fetal Neonatal Ed 95:F295. https:\/\/doi.org\/10.1136\/adc.2009.165878","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"920_CR26","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1111\/apa.12650","volume":"103","author":"S Os","year":"2014","unstructured":"Os S, Cheung P, Pichler G, Aziz K, O\u2019Reilly M, Schm\u00f6lzer GM (2014) Exhaled carbon dioxide can be used to guide respiratory support in the delivery room. Acta Paediatr 103:796\u2013806. https:\/\/doi.org\/10.1111\/apa.12650","journal-title":"Acta Paediatr"},{"key":"920_CR27","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/j.jpeds.2013.07.007","volume":"163","author":"G Pichler","year":"2013","unstructured":"Pichler G, Binder C, Avian A, Beckenbach E, Schm\u00f6lzer GM, Urlesberger B (2013) Reference ranges for regional cerebral tissue oxygen saturation and fractional oxygen extraction in neonates during immediate transition after birth. J Pediatrics 163:1558\u20131563. https:\/\/doi.org\/10.1016\/j.jpeds.2013.07.007","journal-title":"J Pediatrics"},{"key":"920_CR28","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/s0300-9572(02)00031-x","volume":"53","author":"K Markstaller","year":"2002","unstructured":"Markstaller K, Karmrodt J, Doebrich M, Wolcke B, Gervais H, Weiler N et al (2002) Dynamic computed tomography: a novel technique to study lung aeration and atelectasis formation during experimental CPR. Resuscitation 53:307\u2013313. https:\/\/doi.org\/10.1016\/s0300-9572(02)00031-x","journal-title":"Resuscitation"},{"key":"920_CR29","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.resuscitation.2020.05.033","volume":"153","author":"HL Ersdal","year":"2020","unstructured":"Ersdal HL, Eilevstjonn J, Perlman J, Gomo \u00d8, Moshiro R, Mdoe P et al (2020) Establishment of functional residual capacity at birth: observational study of 821 neonatal resuscitations. Resuscitation 153:71\u201378. https:\/\/doi.org\/10.1016\/j.resuscitation.2020.05.033","journal-title":"Resuscitation"},{"key":"920_CR30","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.resuscitation.2021.12.006","volume":"170","author":"BP Aleksander","year":"2022","unstructured":"Aleksander BP, Langli EH, Joanna H, Anastasia U, Knut \u00d8, Siren IR (2022) Tidal volumes and pressures delivered by the NeoPuff T-piece resuscitator during resuscitation of term newborns. Resuscitation 170:222\u2013229. https:\/\/doi.org\/10.1016\/j.resuscitation.2021.12.006","journal-title":"Resuscitation"},{"key":"920_CR31","doi-asserted-by":"publisher","first-page":"F85","DOI":"10.1136\/archdischild-2016-311043","volume":"102","author":"AL Solev\u00e5g","year":"2017","unstructured":"Solev\u00e5g AL, Lee T-F, Lu M, Schm\u00f6lzer GM, Cheung P-Y (2017) Tidal volume delivery during continuous chest compressions and sustained inflation. Arch Dis Child Fetal Neonatal Ed 102:F85. https:\/\/doi.org\/10.1136\/archdischild-2016-311043","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"920_CR32","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/0002-9149(81)90320-9","volume":"48","author":"N Chandra","year":"1981","unstructured":"Chandra N, Weisfeldt ML, Tsitlik J, Vaghaiwalla F, Snyder LD, Hoffecker M et al (1981) Augmentation of carotid flow during cardiopulmonary resuscitation by ventilation at high airway pressure simultaneous with chest compression. Am J Cardiol 48:1053\u20131063. https:\/\/doi.org\/10.1016\/0002-9149(81)90320-9","journal-title":"Am J Cardiol"},{"key":"920_CR33","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1161\/01.cir.67.2.266","volume":"67","author":"RC Koehler","year":"1983","unstructured":"Koehler RC, Tsitlik J, Chandra N, Guerci AD, Rogers MC, Weisfeldt ML (1983) Augmentation of cerebral perfusion by simultaneous chest compression and lung inflation with abdominal binding after cardiac arrest in dogs. Circulation 67:266\u2013275. https:\/\/doi.org\/10.1161\/01.cir.67.2.266","journal-title":"Circulation"},{"key":"920_CR34","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1161\/01.cir.73.3.539","volume":"73","author":"HH Halperin","year":"1986","unstructured":"Halperin HH, Tsitlik J, Guerci AD, Mellits ED, Levin HR, Shi AY et al (1986) Determinants of blood flow to vital organs during cardiopulmonary resuscitation in dogs. Circulation 73:539\u2013550. https:\/\/doi.org\/10.1161\/01.cir.73.3.539","journal-title":"Circulation"},{"key":"920_CR35","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/s0140-6736(80)90662-5","volume":"315","author":"N Chandra","year":"1980","unstructured":"Chandra N, Rudikoff M, Weisfeldt ML (1980) Simultaneous chest compression and ventilation at high airway pressure during cardiopulmonary resuscitation. Lancet 315:175\u2013178. https:\/\/doi.org\/10.1016\/s0140-6736(80)90662-5","journal-title":"Lancet"},{"key":"920_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-024-03373-3","author":"C Morin","year":"2024","unstructured":"Morin C, Lee T-F, O\u2019Reilly M, Ramsie M, Cheung P-Y, Schm\u00f6lzer GM (2024) Cardiopulmonary resuscitation with 3:1 compression:ventilation or continuous compression with asynchronized ventilation in infantile piglets. Pediatr Res. https:\/\/doi.org\/10.1038\/s41390-024-03373-3","journal-title":"Pediatr Res"},{"key":"920_CR37","doi-asserted-by":"publisher","first-page":"100629","DOI":"10.1016\/j.resplu.2024.100629","volume":"18","author":"C Morin","year":"2024","unstructured":"Morin C, Lee T-F, O\u2019Reilly M, Cheung P-Y, Schm\u00f6lzer GM (2024) Continuous chest compression during sustained inflation versus continuous compression with asynchronized ventilation in an infantile porcine model of severe bradycardia. Resusc Plus 18:100629. https:\/\/doi.org\/10.1016\/j.resplu.2024.100629","journal-title":"Resusc Plus"},{"key":"920_CR38","doi-asserted-by":"publisher","first-page":"100459","DOI":"10.1016\/j.resplu.2023.100459","volume":"16","author":"M Ramsie","year":"2023","unstructured":"Ramsie M, Cheung P-Y, Law B, Schm\u00f6lzer GM (2023) Vasopressin versus epinephrine during cardiopulmonary resuscitation of asphyxiated newborns: a study protocol for a prospective, cluster, open label, single-center, randomized controlled phase 2 trial \u2013 the VERSE-Trial. Resusc Plus 16:100459. https:\/\/doi.org\/10.1016\/j.resplu.2023.100459","journal-title":"Resusc Plus"}],"container-title":["Intensive Care Medicine Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40635-026-00920-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40635-026-00920-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40635-026-00920-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:07:08Z","timestamp":1780556828000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s40635-026-00920-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["920"],"URL":"https:\/\/doi.org\/10.1186\/s40635-026-00920-6","relation":{},"ISSN":["2197-425X"],"issn-type":[{"value":"2197-425X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]},"assertion":[{"value":"16 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Approval of the Animal Care and Use Committee (Health Sciences), University of Alberta [AUP00002920]. All authors approved the submission.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"67"}}