{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:55:52Z","timestamp":1790646952511,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["ICMx"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Immediate fluid resuscitation plays a pivotal role in sepsis management. It remains unclear whether a fixed-volume or personalized strategy is more beneficial. Our aim was to compare effectiveness and safety of personalized vs. fixed-volume resuscitation in septic patients in a systematic review and meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic literature search on PubMed, EMBASE and CENTRAL on October 30, 2024. The pre-study protocol was registered with PROSPERO (ID: CRD42024601970). Randomized controlled trials investigated septic patients who received fluid therapy in a personalized way during their initial resuscitation and reported the outcomes of our interest. The meta-analysis was performed using META packages in R with a random-effects model. Risk of bias was assessed using RoB2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The selection yielded 10 eligible randomized controlled trials (RCTs) with 1,011 patients. Data from 8 RCTs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009901) revealed significantly reduced odds of 30-day mortality, (OR: 0.62; 95% CI: 0.42\u20130.93); however, there was no significant difference in the requirement for renal replacement therapy (OR: 0.77; 95% CI: 0.23\u20132.55), duration of mechanical ventilation (MD: 0.27; 95% CI: -3.09-3.63), vasopressor therapy (MD: -3.70; 95% CI: -32.88-25.48) and length of hospital (MD: -0.87; 95% CI: -4.97-3.25) or intensive care unit stay (MD: 0.44; 95% CI: -1.90-2.77).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Personalized fluid resuscitation, compared with fixed-volume resuscitation, indicated reduced 30-day mortality in septic patients. However, the observed mortality benefit should be interpreted cautiously given the relatively small overall sample size, predominance of small single-center studies, and moderate-to-low certainty of evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40635-026-00967-5","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:52:46Z","timestamp":1790585566000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Personalized fluid resuscitation may reduce mortality in septic shock as compared with fixed-volume approach \u2013 a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1186","volume":"14","author":[{"given":"G\u00e1bor","family":"Nagy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia","family":"Holl\u00f3si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caner","family":"Turan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1vid","family":"Laczk\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Sipos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Hegyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Zubek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Moln\u00e1r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"issue":"8","key":"967_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M et al (2016) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). 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No patients were involved in the design, conduct or interpretation of our study.","order":1,"name":"Ethics","label":"Ethics approval\u00a0and consent participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. This manuscript does not contain any individual person\u2019s data in any form, and all data are anonymized.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Professor Zsolt Moln\u00e1r receives honoraria for lectures and consultations from CytoSorbents Europe, Thermo Fisher, Baxter, PULSION Medical (Getinge Group), Nutricia, and Biotest.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"126"}}