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However, it remains unclear whether, and to what extent an extra-abdominal trauma, such as thoracic trauma with transient hemorrhagic shock and hind-limb ischemia (THS), provokes remote intestinal alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A post hoc analysis was performed using jejunal tissue from a standardized murine THS model. Histological, immunohistochemical, and molecular analyses evaluated epithelial integrity, barrier components, and immune responses 24\u00a0h after the insult.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Histological assessment of the intestine revealed no overt morphological damage. Nonetheless, jejunal expression of\n                      <jats:italic>Tnk1<\/jats:italic>\n                      and\n                      <jats:italic>Ripk3<\/jats:italic>\n                      was significantly increased, indicating epithelial stress and activation of necroptotic signaling. Tight junction marker\n                      <jats:italic>Tjp1<\/jats:italic>\n                      was upregulated, while\n                      <jats:italic>Muc2<\/jats:italic>\n                      was reduced. Intestinal expression levels of\n                      <jats:italic>Il6<\/jats:italic>\n                      and\n                      <jats:italic>Ifng<\/jats:italic>\n                      declined, paralleled by a decrease in CD3\u207a T cells, whereas\n                      <jats:italic>Lcn2<\/jats:italic>\n                      levels increased.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Thoracic trauma combined with transient hemorrhagic shock including hind-limb ischemia induces remote intestinal alterations, characterized by epithelial stress, compensatory barrier reinforcement, and reduced mucosal immunity. These findings highlight the gut\u2019s sensitivity to extra-abdominal trauma and its potential contribution to systemic injury propagation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40635-026-00970-w","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:58:45Z","timestamp":1789721925000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Remote intestinal changes following blast-induced thoracic trauma with transient hemorrhagic shock and hind-limb ischemia"],"prefix":"10.1186","volume":"14","author":[{"given":"Sophie","family":"Meisen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Doerfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Mannes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Hildebrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kleger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Halbgebauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2359-6516","authenticated-orcid":false,"given":"Markus","family":"Huber-Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"issue":"3","key":"970_CR1","doi-asserted-by":"publisher","first-page":"L397","DOI":"10.1152\/ajplung.00052.2025","volume":"329","author":"M Palmier","year":"2025","unstructured":"Palmier M, Fraineau S, Sutton A, Hlawaty H, Bellien J, Plissonnier D (2025) The pathophysiology of acute lung injury following intestinal ischemia-reperfusion. 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