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Two radiologists assessed subjective image quality parameters independently. The Wilcoxon signed-rank test was used to compare subjective qualitative image score. Objective quality values and the mean ADC values were analyzed by paired <jats:italic>t<\/jats:italic>-test. The correlation between pathological results and mean ADC value were estimated using Spearman rank correlation analysis.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The CNR value (10.23\u2009\u00b1\u20092.92) and image quality score (13.84\u2009\u00b1\u20091.07) of r-FOV DWI were significantly higher than those of f-FOV DWI (5.24\u2009\u00b1\u20091.29 <jats:bold><jats:italic>P<\/jats:italic><\/jats:bold>&lt;0.001; 10.41\u2009\u00b1\u20091.11 P&lt;0.001). There was no significant difference between mean ADC values of the two DWI sequences for all three groups (Group 1, chronic cholecystitis; Group 2, benign lesions of gallbladder; Group 3, gallbladder carcinoma. <jats:italic>P<\/jats:italic>\u2009=\u20090.239, 0.974 and 0.226 respectively). For both DWI sequences, the mean ADC values were the highest in the group of cholecystitis and the lowest in the group of gallbladder carcinoma (2.49\u2009\u00b1\u20090.14 vs 1.49\u2009\u00b1\u20090.12; 2.50\u2009\u00b1\u20090.14 vs 1.50\u2009\u00b1\u20090.13, for f-FOV and r-FOV respectively), the differences among groups were statistically significant (<jats:italic>P<\/jats:italic>&lt;0.01). The mean ADC values for both DWI sequences were negatively correlated with the group number, which increased with the malignant tendency of lesions (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212\u20090.892, P&lt;0.01; r\u2009=\u2009\u2212\u20090.913, P&lt;0.01 for f-FOV and r-FOV respectively).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Reduced Field-of-view Diffusion-weighted MRI is a good tool to diagnosis the gallbladder carcinoma, with better image quality and without affecting ADC values.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s40644-020-00326-x","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T14:26:01Z","timestamp":1594995961000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Gallbladder carcinoma: an initial clinical experience of reduced field-of-view diffusion-weighted MRI"],"prefix":"10.1186","volume":"20","author":[{"given":"Sisi","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianlun","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daoyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2346-3150","authenticated-orcid":false,"given":"Chuou","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,17]]},"reference":[{"key":"326_CR1","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.surge.2015.12.001","volume":"14","author":"NR Bhatt","year":"2016","unstructured":"Bhatt NR, Gillis A, Smoothey CO, et al. 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All authors have contributed significantly, and that all authors are in agreement with the content of the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"50"}}