{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:50:23Z","timestamp":1776981023489,"version":"3.51.4"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Imaging"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>To demonstrate and analyze the relatively common imaging findings in this rare primary pleural angiosarcoma (PPA).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>Three cases of PPA, proven by video-assisted thoracic surgery biopsies are retrospectively reviewed. Patients were all male. Age ranges from 65 to 75 years old age (mean; 69). Major chief complaints were dyspnea and chest pain. One has a history of colon cancer, the other has a tuberculosis history and the other has no known history. Multidetector chest CT and PET CT were all done. Immunohistochemical studies were performed including CD31, CD34, or factor VIII-related antigen, vimentin, and cytokeratin. We also review the literatures on recently published PPA. All masses were from 1 to 10 cm. All three patients had multiple pleural based masses, which were ovoid in shape with relatively sharp margin in unilateral hemithorax. Multiple small circumscribed pleural masses are limited in the pleural space in two patients, whereas two, huge lobulated masses about up to 10 cm were present with pleural and extrapleural involvement in one patient. In two patients with pleural mass only, multiple pleural masses were only seen in parietal pleura in one patient and were in both visceral and parietal pleura in one patient. Pleural effusion were found in one side in one patient and in both sides in one patient. One angiosarcoma was arised from chronic tuberculotic pleurisy sequelae. All pleural masses are heterogenous with irregular internal low densities in all patients. Hematogenous metastases were found in liver, vertebra, rib in one patient, and were in lungs with mediastinal lymph node metastases in the other patient. Three patients survived for longer than 3months after diagnosis, but continued to deteriorate rapidly. Two patients underwent chemotherapy after surgical excision, and the other one with multiple metastases treated chemotherapy after CT-guided biopsy, but eventually all died. As a result of comparative analysis of a total of 13 patients\u2019 images including 10 cases previously published, there was pleural effusion in all except 2 cases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>PPA were all necrotic without any vascularized enhancing nature, and manifested as unilateral circumscribed or localized pleural-based masses.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40644-021-00435-1","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T17:02:53Z","timestamp":1642006973000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multidetector CT findings of primary pleural angiosarcoma : a systematic review, an additional cases report"],"prefix":"10.1186","volume":"22","author":[{"given":"Bo Mi","family":"Gil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Hee","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki-Nam","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Im","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Jong","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Seog","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heejeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"435_CR1","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1097\/00000658-194309000-00014","volume":"118","author":"AP Stout","year":"1943","unstructured":"Stout AP. Hemangio-endothelioma: A tumor of blood vessels featuring vascular endothelial cells. Ann Surg. 1943;118:445\u201364.","journal-title":"Ann Surg."},{"key":"435_CR2","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/S1010-7940(98)00211-5","volume":"14","author":"C Alexiou","year":"1998","unstructured":"Alexiou C, Clelland CA, Robinson D, Morgan WE. Primary angiosarcomas of the chest wall and pleura. Eur J Cardiothorac Surg. 1998;14:523\u20136.","journal-title":"Eur J Cardiothorac Surg."},{"key":"435_CR3","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1056\/NEJM198704023161423","volume":"316","author":"AC Moncure","year":"1987","unstructured":"Moncure AC, Mark EJ. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 17-1987. A 38-year-old woman with a history of radiation treatment for a malignant tumor in the right hemithorax and persistent chest pain and pleural abnormality. N Engl J Med. 1987;316:1075\u201383.","journal-title":"N Engl J Med."},{"key":"435_CR4","doi-asserted-by":"publisher","first-page":"e157","DOI":"10.1016\/j.chest.2015.12.022","volume":"149","author":"MB Patel","year":"2016","unstructured":"Patel MB, Munzer K, Dougherty M, Williams P, Loiselle A. Pleural Myiasis Associated With Pleural Angiosarcoma. Chest. 2016;149:e157\u201360.","journal-title":"Chest."},{"key":"435_CR5","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1093\/icvts\/ivt269","volume":"17","author":"CY Chen","year":"2013","unstructured":"Chen CY, Wu YC, Chou TY, Yang KY. Pleural angiosarcoma mimicking pleural haematoma. Interact Cardiovasc Thorac Surg. 2013;17:886\u20138.","journal-title":"Interact Cardiovasc Thorac Surg."},{"key":"435_CR6","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1055\/s-2007-1012020","volume":"44","author":"T Suzuki","year":"1996","unstructured":"Suzuki T, Suzuki S, Kitami A, Kamio Y, Hori G, Mitsuya T, et al. Angiosarcoma of the chest wall. Thorac Cardiovasc Surg. 1996;44:213\u20135.","journal-title":"Thorac Cardiovasc Surg."},{"key":"435_CR7","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/S0003-4975(99)00073-9","volume":"67","author":"DE Maziak","year":"1999","unstructured":"Maziak DE, Shamji FM, Peterson R, Perkins DG. Angiosarcoma of the chest wall. Ann Thorac Surg. 1999;67:839\u201341.","journal-title":"Ann Thorac Surg."},{"key":"435_CR8","first-page":"906","volume":"7","author":"K Aozasa","year":"1994","unstructured":"Aozasa K, Naka N, Tomita Y, Ohsawa M, Kanno H, Uchida A, et al. Angiosarcoma developing from chronic pyothorax. Mod Pathol. 1994;7:906\u201311.","journal-title":"Mod Pathol."},{"key":"435_CR9","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11<2400::AID-CNCR32>3.0.CO;2-Z","volume":"77","author":"RJ Mark","year":"1996","unstructured":"Mark RJ, Poen JC, Tran LM, Fu YS, Juillard GF. Angiosarcoma. A report of 67 patients and a review of the literature. Cancer. 1996;77:2400\u20136.","journal-title":"Cancer."}],"container-title":["Cancer Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40644-021-00435-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40644-021-00435-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40644-021-00435-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T17:17:19Z","timestamp":1642007839000},"score":1,"resource":{"primary":{"URL":"https:\/\/cancerimagingjournal.biomedcentral.com\/articles\/10.1186\/s40644-021-00435-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,12]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["435"],"URL":"https:\/\/doi.org\/10.1186\/s40644-021-00435-1","relation":{},"ISSN":["1470-7330"],"issn-type":[{"value":"1470-7330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,12]]},"assertion":[{"value":"29 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the institutional review board of our hospital (IRB number: XC20RIDI0031). The IRB waived the need for informed consent as this study was a retrospective study using data obtained using standard clinical protocols.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors read and approved the final manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6"}}