{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:06:38Z","timestamp":1775081198689,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008235","name":"Peking Union Medical College Hospital","doi-asserted-by":"publisher","award":["XJS20210104"],"award-info":[{"award-number":["XJS20210104"]}],"id":[{"id":"10.13039\/501100008235","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008235","name":"Peking Union Medical College Hospital","doi-asserted-by":"publisher","award":["2022-PUMCH-B-066"],"award-info":[{"award-number":["2022-PUMCH-B-066"]}],"id":[{"id":"10.13039\/501100008235","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018754","name":"Science and Technology Plan Projects of Tibet Autonomous Region","doi-asserted-by":"publisher","award":["XZ201901-GB-04"],"award-info":[{"award-number":["XZ201901-GB-04"]}],"id":[{"id":"10.13039\/501100018754","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Imaging"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>Parathyroid carcinoma (PC) and atypical parathyroid tumor (APT) are rare parathyroid disorders carrying the risk of recurrence of varying degrees. This study aims to explore the value of 2D-shear wave elastography (SWE) in the discrimination of PC\/APT among suspicious parathyroid lesions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods and materials<\/jats:title>\n                <jats:p>In this prospective study, patients with primary hyperparathyroidism and suspicious parathyroid lesions on ultrasonography (US) were recruited. All the lesions were assessed by SWE before surgery. The velocity (m\/s), Young\u2019s modulus (Kpa), and elastogram of SWE were compared between pathologically proven parathyroid carcinoma or atypical parathyroid tumor (Group1) and parathyroid adenoma (Group2). All the SWE parameters were displayed at the setting of 50 or 70\u2009kPa. Correlations between SWE and the lesion size as well as biochemical parameters were analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>36 target lesions were enrolled for analysis. The mean shear wave velocity (SWV) between the two groups was 2.4\u2009m\/s vs 1.9\u2009m\/s, respectively, while the mean Young\u2019s modulus was 11.1\u2009kPa vs 18.2\u2009kPa, respectively. The cut-off values are 2.35\u2009m\/s and 17.05\u2009kPa correspondingly. The sensitivity and specificity of the selecting cut-off values were 0.56 vs 0.63 and 0.95 vs 1.0 (area under the curve [AUC]: 0.813 vs 0.852 [95% confidence interval (CI): 0.669\u20130.956 vs 0.720\u20130.983]; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009\u00a00.001, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009\u00a00.001; respectively). In contrast, the max SWV and Young\u2019s modulus showed a better sensitivity of 0.75 and 0.81, respectively. The \u201ccolored lesion\u201d and \u201cstiff rim\u201d patterns on the elastogram are more indicated in parathyroid carcinoma and atypical parathyroid tumor, whereas the negative elastogram prevails in parathyroid adenoma. The SWV and Young\u2019s modulus of the parathyroid lesions were independent of the tumor size, but the max SWV and Young\u2019s modulus slightly correlated with serum parathyroid hormone concentration (PTH) (r\u2009=\u20090.398, <jats:italic>p<\/jats:italic>\u2009=\u20090.016; r\u2009=\u20090.396, <jats:italic>p<\/jats:italic>\u2009=\u20090.017).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>2D-shear wave elastography plays a useful role in the preoperative assessment of parathyroid lesions with suspicious malignancy. The mean SWV and Young\u2019s modulus are advised as the favored diagnostic parameter with the best AUC and excellent specificities, while the max SWV and Young\u2019s modulus are more sensitive to distinguish the PC and APT compared with other parameters.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40644-022-00503-0","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T01:27:19Z","timestamp":1669166839000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Shear wave elastography for differentiating parathyroid neoplasms with malignant diagnosis or uncertain malignant potential from parathyroid adenomas: initial experience"],"prefix":"10.1186","volume":"22","author":[{"given":"Ruifeng","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luying","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinlong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weibo","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5248-9870","authenticated-orcid":false,"given":"Yu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"issue":"11","key":"503_CR1","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1056\/NEJMcp1714213","volume":"379","author":"KL Insogna","year":"2018","unstructured":"Insogna KL. 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Written consents were obtained from each patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have declared that no competing interests exist.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"64"}}