{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:44:32Z","timestamp":1787021072122,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Imaging"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n This study aimed to compare the diagnostic value of [\n 68<\/jats:sup>\n \u00a0Ga]Ga-DOTA-FAPI-04 and [\n 18<\/jats:sup>\n F]FDG PET\/CT imaging for primary lesions and metastatic lymph nodes in patients with tonsil cancer.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n Twenty-one tonsil cancer patients who underwent [\n 68<\/jats:sup>\n \u00a0Ga]Ga-DOTA-FAPI-04 and [\n 18<\/jats:sup>\n F]FDG PET\/CT scans within two weeks in our centre were retrospectively enrolled. The maximum standardized uptake value (SUVmax) and tumor-to-background ratio (TBR) of the two tracers were compared by using the Mann\u2012Whitney U test. In addition, the sensitivity, specificity, and accuracy of the two methods for diagnosing metastatic lymph nodes were analysed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In detecting primary lesions, the efficiency was higher for [\n 68<\/jats:sup>\n \u00a0Ga]Ga-DOTA-FAPI-04 PET\/CT (20\/22) than for [\n 18<\/jats:sup>\n F]FDG PET\/CT (9\/22). Although [\n 68<\/jats:sup>\n \u00a0Ga]Ga-DOTA-FAPI-04 uptake (SUVmax, 5.03\u2009\u00b1\u20094.06) was lower than [\n 18<\/jats:sup>\n F]FDG uptake (SUVmax, 7.90\u2009\u00b1\u20094.84, P\u2009=\u20090.006), [\n 68<\/jats:sup>\n \u00a0Ga]Ga-DOTA-FAPI-04 improved the distinction between the primary tumor and contralateral normal tonsillar tissue. The TBR was significantly higher for [\n 68<\/jats:sup>\n \u00a0Ga]Ga-DOTA-FAPI-04 PET\/CT (3.19\u2009\u00b1\u20092.06) than for [\n 18<\/jats:sup>\n F]FDG PET\/CT (1.89\u2009\u00b1\u20091.80) (p\u2009<\u20090.001). In lymph node analysis, SUVmax and TBR were not significantly different between [\n 68<\/jats:sup>\n \u00a0Ga]Ga-DOTA-FAPI-04 and [\n 18<\/jats:sup>\n F]FDG PET\/CT (7.67\u2009\u00b1\u20095.88 vs. 8.36\u2009\u00b1\u20096.15, P\u2009=\u20090.498 and 5.56\u2009\u00b1\u20094.02 vs. 4.26\u2009\u00b1\u20093.16, P\u2009=\u20090.123, respectively). The specificity and accuracy of [\n 68<\/jats:sup>\n \u00a0Ga]Ga-DOTA-FAPI-04 PET\/CT were higher than those of [\n 18<\/jats:sup>\n F]FDG PET\/CT in diagnosing metastatic cervical lymph nodes (all P\u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The availability of [\n 68<\/jats:sup>\n \u00a0Ga]Ga-DOTA-FAPI-04 complements the diagnostic results of [\n 18<\/jats:sup>\n F]FDG by improving the detection rate of primary lesions and the diagnostic accuracy of cervical metastatic lymph nodes in tonsil cancer compared to [\n 18<\/jats:sup>\n F]FDG.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s40644-024-00699-3","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T09:01:37Z","timestamp":1714726897000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Head-to-head comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET\/CT for the evaluation of tonsil cancer and lymph node metastases: a single-centre retrospective study"],"prefix":"10.1186","volume":"24","author":[{"given":"Mengjing","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoli","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"issue":"1","key":"699_CR1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","volume":"6","author":"DE Johnson","year":"2020","unstructured":"Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. 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