{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:31:13Z","timestamp":1772166673355,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Imaging"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Two-deoxy-2-[fluorine-18]-fluoro-d-glucose (\n 18<\/jats:sup>\n F-FDG) positron emission tomography (PET) is useful for detecting malignant lesions; however, the clinical significance of cardiac\n 18<\/jats:sup>\n F-FDG uptake in patients with cancer remains unclear. This preliminary study explored the relationship between cardiac\n 18<\/jats:sup>\n F-FDG uptake and advanced diseases such as cancer cachexia in non-small cell lung cancer (NSCLC).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Forty-three patients with advanced NSCLC who underwent\n 18<\/jats:sup>\n F-FDG PET and complained of weight loss before the first-line systemic therapy were retrospectively included in this study. Visual assessment using a 5-point scale based on\n 18<\/jats:sup>\n F-FDG uptake was performed; a cut-off score of 3 was determined, a low score was 1, 2, or 3, and a high score was 4 or 5).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n High and low visual cardiac\n 18<\/jats:sup>\n F-FDG uptakes were observed in 27 (62.8%) and 16 (37.2%) patients, respectively. Of the 43 patients, 17 (39.5%) definitely had cachexia, and 26 (60.5%) did not. A low visual score and standardized uptake value\n max<\/jats:sub>\n for cardiac\n 18<\/jats:sup>\n F-FDG uptake were significantly associated with high metabolic tumor activity (\n p<\/jats:italic>\n \u2009=\u20090.009, and\n p<\/jats:italic>\n \u2009=\u20090.009, respectively) and a high neutrophil-to-lymphocyte ratio (\n p<\/jats:italic>\n \u2009=\u20090.016, and\n p<\/jats:italic>\n \u2009=\u20090.047, respectively), whereas a low visual score for cardiac\n 18<\/jats:sup>\n F-FDG uptake and high metabolic tumor activity were significantly associated with cachexia (\n p<\/jats:italic>\n \u2009=\u20090.004). The amount of cardiac\n 18<\/jats:sup>\n F-FDG accumulation depicted a close relationship with body mass index, low weight loss, and inflammation. The combination of cachexia and low visual cardiac\n 18<\/jats:sup>\n F-FDG uptake was identified as a significant predictor for poor overall survival (OS) (\n p<\/jats:italic>\n \u2009=\u20090.034).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Decreased visual cardiac\n 18<\/jats:sup>\n F-FDG uptake was associated with poor nutritional status and OS, and cachexia in patients with advanced NSCLC.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s40644-024-00800-w","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T03:54:19Z","timestamp":1731902059000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical significance of visual cardiac 18F-FDG uptake in advanced non-small cell lung cancer"],"prefix":"10.1186","volume":"24","author":[{"given":"Kosuke","family":"Hashimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoichi","family":"Kaira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisao","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ou","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuto","family":"Mouri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Shiono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kagamu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiei","family":"Kuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"800_CR1","doi-asserted-by":"publisher","first-page":"3746","DOI":"10.1200\/JCO.2009.27.4662","volume":"28","author":"K Kaira","year":"2010","unstructured":"Kaira K, Endo M, Abe M, Nakagawa K, Ohde Y, Okumura T, et al. 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