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Semi-quantitative parameters, including SUV\n                      <jats:sub>max<\/jats:sub>\n                      , tumor\/liver ratio (T\/L), tumor\/mediastinal blood pool ratio (T\/B), were analyzed. The tracer uptake was compared via Wilcoxon tests. The relationships between\n                      <jats:sup>18<\/jats:sup>\n                      F-FAPI-04 uptake with FAP and \u03b1-SMA expression were analyzed using Pearson correlation. Patients were divided into different short-term outcome groups (responders vs. non-responders) according to RECIST criteria (v.1.1) after chemotherapy. Post-chemotherapy outcomes were evaluated using logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients (median age 62; 16 females, 23 males) included pancreatic (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200917), cholangiocarcinoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098), gastric (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096), and colorectal cancers (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098).\n                      <jats:sup>18<\/jats:sup>\n                      F-FAPI-04 demonstrated significantly higher SUV\n                      <jats:sub>max<\/jats:sub>\n                      , T\/L, and T\/B than\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Pancreaticobiliary cancers (pancreatic\/cholangiocarcinoma) exhibited higher 18F-FAPI-04 uptake than gastroenteric cancers (gastric\/colorectal) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), though no differences existed within subgroups.\n                      <jats:sup>18<\/jats:sup>\n                      F-FAPI-04 parameters positively correlated with FAP and \u03b1-SMA expression. In univariate analysis,\n                      <jats:sup>18<\/jats:sup>\n                      F-FAPI-04 uptake differed significantly between responders and non-responders. Multivariate analysis identified SUV\n                      <jats:sub>max<\/jats:sub>\n                      as an independent predictor (OR\u2009=\u20091.354, 95%CI:1.025\u20131.788,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.033). Optimal\n                      <jats:sup>18<\/jats:sup>\n                      F-FAPI-04 cut-offs for distinguishing outcomes were SUV\n                      <jats:sub>max<\/jats:sub>\n                      =11.05 (AUC\u2009=\u20090.783; sensitivity\u2009=\u200970.60%, specificity\u2009=\u200980.40%), T\/L\u2009=\u20097.53 (AUC\u2009=\u20090.717; 58.82%, 81.82%), and T\/B\u2009=\u20098.76 (AUC\u2009=\u20090.751; 64.71%, 86.37%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:sup>18<\/jats:sup>\n                      F-FAPI-04 PET\/CT outperforms\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG in PM detection, with semi-quantitative parameters predicting chemotherapy response.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40644-025-00887-9","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T03:59:54Z","timestamp":1748836794000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Characteristics of 18F-FAPI-04 PET\/CT in patients with peritoneal metastasis and to predict treatment efficacy, a head-to-head comparison with 18F-FDG PET\/CT"],"prefix":"10.1186","volume":"25","author":[{"given":"Yafei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangfa","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"issue":"3","key":"887_CR1","doi-asserted-by":"publisher","first-page":"e15914","DOI":"10.15252\/emmm.202215914","volume":"15","author":"S Bootsma","year":"2023","unstructured":"Bootsma S, Bijlsma MF, Vermeulen L. 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