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Basic assumptions include the permanent trapping of microspheres, the local energy deposition method for voxel\u00a0dosimetry, and the patient\u2013relative calibration method for activity quantification.The identity of <jats:sup>99m<\/jats:sup>Tc albumin macro-aggregates (MAA) and <jats:sup>90<\/jats:sup>Y microsphere biodistribution is also assumed. The large observed discrepancies in some patients between <jats:sup>99m<\/jats:sup>Tc-MAA predictions and actual <jats:sup>90<\/jats:sup>Y microsphere distributions for lesions is discussed. Absorbed dose predictions to whole\u00a0non-tumoural liver are considered more reliable and the basic predictors of toxicity. Treatment planning based on mean absorbed dose delivered to the whole non-tumoural liver is advised, except in super-selective treatments.<\/jats:p><jats:p>Given the potential mismatch between MAA simulation and actual therapy, absorbed doses should be calculated both pre- and post-therapy. Distinct evaluation between target tumours and non-tumoural tissue, including lungs in cases of lung shunt, are vital for proper optimization of therapy. Dosimetry should be performed first according to a mean absorbed dose approach, with an optional, but important, voxel level evaluation. Fully corrected <jats:sup>99m<\/jats:sup>Tc-MAA Single Photon Emission\u00a0Computed Tomography (SPECT)\/computed tomography (CT) and <jats:sup>90<\/jats:sup>Y TOF PET\/CT are regarded as optimal acquisition methodologies, but, for institutes where SPECT\/CT is not available, non-attenuation corrected <jats:sup>99m<\/jats:sup>Tc-MAA SPECT may be used. This offers better planning quality than non dosimetric methods such as Body Surface Area (BSA) or mono-compartmental dosimetry. Quantitative <jats:sup>90<\/jats:sup>Y bremsstrahlung SPECT can be used if dedicated correction methods are available.<\/jats:p><jats:p>The proposed methodology is feasible with standard camera software and a spreadsheet. 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