{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:18:25Z","timestamp":1758845905474,"version":"3.44.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100020098","name":"Innovative Health Initiative","doi-asserted-by":"publisher","award":["101112053"],"award-info":[{"award-number":["101112053"]}],"id":[{"id":"10.13039\/100020098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EJNMMI Phys"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>\n              <jats:sup>99m<\/jats:sup>Tc-macroaggregated albumin (MAA) imaging is part of the standard work-up procedure for radioembolization using <jats:sup>90<\/jats:sup>Y microspheres. In certain scenarios, it may be warranted to visualize the distribution of <jats:sup>99m<\/jats:sup>Tc in co-presence of <jats:sup>90<\/jats:sup>Y, for example when validating intra-procedural <jats:sup>99m<\/jats:sup>Tc-MAA imaging after <jats:sup>90<\/jats:sup>Y-therapy to enable single-session radioembolization. Another instance involves additional <jats:sup>99m<\/jats:sup>Tc-MAA administration during the therapeutic procedure itself, e.g. when initial imaging reveals insufficient targeting of a specific liver segment. In these situations, crosstalk from <jats:sup>90<\/jats:sup>Y can result in reduced <jats:sup>99m<\/jats:sup>Tc image quality and quantitative accuracy. This study investigates the feasibility and optimal method of <jats:sup>99m<\/jats:sup>Tc SPECT imaging from combined <jats:sup>99m<\/jats:sup>Tc+<jats:sup>90<\/jats:sup>Y data using phantom experiments.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>An anthropomorphic torso phantom with two liver tumor inserts was filled with <jats:sup>99m<\/jats:sup>Tc without (single-isotope) and with <jats:sup>90<\/jats:sup>Y (dual-isotope) in various activities and isotope concentrations. Three collimators (low energy high resolution: LEHR, medium energy: ME, and high energy: HE) and three methods to compensate for <jats:sup>90<\/jats:sup>Y crosstalk in the <jats:sup>99m<\/jats:sup>Tc photo peak window (Monte Carlo-based, dual-energy-window and triple-energy-window correction) were evaluated. No substantial dead-time effects were observed in the clinically relevant activity range, up to approximately 12 GBq <jats:sup>99m<\/jats:sup>Tc+<jats:sup>90<\/jats:sup>Y (ratio 1:20) with LEHR, 29 GBq with ME and &gt;\u200930 GBq with HE. Compared to the clinical standard (single-isotope <jats:sup>99m<\/jats:sup>Tc imaging with LEHR collimator), contrast recovery typically decreased from 70.0\u2009\u00b1\u20091.3% to 49.0\u2009\u00b1\u20090.9% (LEHR), 61.2\u2009\u00b1\u20091.5% (ME) or 62.1\u2009\u00b1\u20091.4% (HE) due to <jats:sup>90<\/jats:sup>Y crosstalk. Compensation methods increased contrast recovery, with Monte Carlo-based correction combined with a ME or HE collimator yielding the best recovery at 68.5\u2009\u00b1\u20091.6% and 68.3\u2009\u00b1\u20091.5%, respectively. Visual image quality in terms of resolution and scatter contamination was superior when using a ME collimator. Lung shunt fractions were also severely affected by <jats:sup>90<\/jats:sup>Y crosstalk when using LEHR, but could be effectively mitigated using a ME or HE collimator.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>\n              <jats:sup>99m<\/jats:sup>Tc imaging in the presence of <jats:sup>90<\/jats:sup>Y leads to substantial image degradation due to crosstalk effects. Monte Carlo-based crosstalk compensation in combination with a ME or HE collimator was identified as the most accurate, robust and visually optimal reconstruction method for <jats:sup>99m<\/jats:sup>Tc SPECT from dual-isotope data.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s40658-025-00798-5","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:22:03Z","timestamp":1758806523000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimization of 99mTc-SPECT in the presence of 90Y for radioembolization"],"prefix":"10.1186","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1535-6951","authenticated-orcid":false,"given":"Camiel E.M.","family":"Kerckhaert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn M.A.","family":"Dietze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob","family":"van Rooij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjolein B.M.","family":"Meddens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niek","family":"Wijnen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten L.J.","family":"Smits","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marnix G.E.H.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo W.A.M.","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"798_CR1","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1097\/01.RVI.0000233785.75257.9A","volume":"17","author":"R Salem","year":"2006","unstructured":"Salem R, Thurston KG. 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