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To achieve this goal, four signals were recorded simultaneously: blood pressure, heart rate \/ electrocardiogram, HbO\n                      <jats:sub>2<\/jats:sub>\n                      \u00a0from right hemisphere and changes of subarachnoid space (SAS) width from left hemisphere. Signals were registered from 30 healthy, young participants (2 females and 28 males, body mass index =\u200924.5\u2009\u00b1\u20092.3\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , age 30.8\u2009\u00b1\u200913.4\u00a0years).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We analysed the recorded signals using wavelet transform and phase coherence. We demonstrated for the first time that in healthy subjects exposed to mild poikilokapnic hypoxia there were increases in very low frequency HbO\n                      <jats:sub>2<\/jats:sub>\n                      oscillations (&lt;\u20090.052\u00a0Hz) in prefrontal cortex. Additionally, SAS fluctuation diminished in the whole frequency range which could be explained by brain oedema.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Consequently the study provides insight into mechanisms governing brain response to a mild hypoxic challenge. Our study supports the notion that HbO\n                      <jats:sub>2<\/jats:sub>\n                      and SAS width monitoring might be beneficial for patients with acute lung disease.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40659-021-00362-2","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T05:02:55Z","timestamp":1639458175000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex"],"prefix":"10.1186","volume":"54","author":[{"given":"Agnieszka","family":"Gruszecka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Waskow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta A.","family":"Malkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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