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All patients underwent a complete ocular examination, including evaluations of clinical manifestations of AC, corneal tomography and densitometry by Pentacam, corneal biomechanics by Corvis ST, and corneal and epithelial thickness mapping by RTvue optical coherence tomography (OCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The index of surface variance (ISV), index of vertical asymmetry (IVA), keratoconus index (KI), index of height decentration (IHD) and Belin\/Ambrosio enhanced ectasia total deviation index (BAD-D) were significantly higher in the AC group than in the non-allergic conjunctivitis (NAC) group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). The tomography and biomechanical index (TBI) was also significantly higher in the AC group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.04). The average epithelial thickness in the 2\u20137\u2009mm annulus was significantly thinner in the AC group than in the NAC group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). The average densitometry of the total cornea and the anterior layer were higher in the AC group than in the NAC group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The ISV, IVA, KI, IHD and BAD-D were significantly correlated with the TBI and changes in corneal epithelial thickness in AC patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). The changes in epithelial thickness were closely related to the eye rubbing frequency and allergic sign scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AC patients should be advised to routinely undergo corneal tomographic and biomechanical measurements, and the TBI could be used as an indicator of KC development risk in AC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      Corneal Biomechanical Changes of Allergic Conjunctivitis,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04299399\">NCT04299399<\/jats:ext-link>\n                      . Registered March 3, 2020 - Retrospectively registered.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40662-021-00241-7","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T10:52:19Z","timestamp":1620039139000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Corneal biomechanical changes in allergic conjunctivitis"],"prefix":"10.1186","volume":"8","author":[{"given":"Qian","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiqun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5756-5414","authenticated-orcid":false,"given":"Jin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"issue":"5","key":"241_CR1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/j.1755-3768.2011.02272.x","volume":"90","author":"BP Bielory","year":"2012","unstructured":"Bielory BP, O\u2019Brien TP, Bielory L. 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Cornea. 2018;37(5):560\u20136.","DOI":"10.1097\/ICO.0000000000001505"}],"container-title":["Eye and Vision"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40662-021-00241-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40662-021-00241-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40662-021-00241-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T10:54:00Z","timestamp":1620039240000},"score":1,"resource":{"primary":{"URL":"https:\/\/eandv.biomedcentral.com\/articles\/10.1186\/s40662-021-00241-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,3]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["241"],"URL":"https:\/\/doi.org\/10.1186\/s40662-021-00241-7","relation":{},"ISSN":["2326-0254"],"issn-type":[{"value":"2326-0254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,3]]},"assertion":[{"value":"30 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of Zhongshan Ophthalmic Center, Sun Yat-Sen University (2020KYPJ008). All patients (or the patient\u2019s legal guardian) provided informed consent before the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17"}}