{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:14:37Z","timestamp":1789877677494,"version":"4.0.1"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eye and Vis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The short- and medium-term outcomes of iStent have been extensively studied; however, only few studies have investigated its long-term outcomes. Here, we assessed the long-term efficacy and safety of two iStents with concomitant cataract surgery in glaucomatous eyes while also evaluating measures of disease stability using visual field and optical coherence tomography (OCT) of the optic nerve and the macula throughout 8\u00a0years of follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This longitudinal, single-center consecutive case series included glaucomatous eyes that underwent implantation of two first-generation trabecular micro-bypass stents (iStent) with concomitant cataract surgery. Eight-year efficacy outcomes included mean intraocular pressure (IOP) and medications, as well as surgical success. Eight-year safety outcomes included best-corrected visual acuity (BCVA), visual field mean deviation (VF-MD), cup-to-disc ratio (CDR), retinal nerve fiber layer (RNFL) thickness, ganglion cell-inner plexiform layer (GC-IPL) thickness, and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 62 eyes with primary open-angle glaucoma (POAG) were included. At 8\u00a0years postoperative, IOP reduced by 26% from 19.2\u2009\u00b1\u20093.9\u00a0mmHg preoperatively to 14.2\u2009\u00b1\u20092.4\u00a0mmHg (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), 91.1% of eyes achieved IOP\u2009\u2264\u200918\u00a0mmHg (vs. 51.6% preoperatively), 69.6% of eyes achieved IOP\u2009\u2264\u200915\u00a0mmHg (vs. 14.5% preoperatively), and 25% of eyes achieved IOP\u2009\u2264\u200912\u00a0mmHg (vs. 1.6% preoperatively). Medication use decreased by 17.9% from 2.8\u2009\u00b1\u20091.1 preoperatively to 2.3\u2009\u00b1\u20091.2 (<jats:italic>P<\/jats:italic>\u2009=\u20090.018). Surgical success was 90%, as six eyes underwent subsequent glaucoma surgeries. Safety measures of BCVA, CDR, RNFL thickness and GC-IPL thickness remained stable through 8\u00a0years postoperative. VF-MD remained stable until postoperative year 5 and subsequently progressed according to the natural history of glaucomatous disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Implantation of two iStents with concomitant cataract surgery is an effective and safe treatment option for surgery-na\u00efve POAG eyes, evidenced by significant IOP and medication reductions, reasonable surgical success, and favorable safety outcomes, throughout the 8-year follow-up. Our data additionally supports the efficacy of this combined procedure in stabilizing or slowing disease progression.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s40662-021-00263-1","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:02:52Z","timestamp":1637020972000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Long-term outcomes of two first-generation trabecular micro-bypass stents (iStent) with phacoemulsification in primary open-angle glaucoma: eight-year results"],"prefix":"10.1186","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0016-3478","authenticated-orcid":false,"given":"Ali","family":"Salimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison","family":"Watt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Harasymowycz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"issue":"18","key":"263_CR1","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","volume":"311","author":"RN Weinreb","year":"2014","unstructured":"Weinreb RN, Aung T, Medeiros FA. The pathophysiology and treatment of glaucoma: a review. JAMA. 2014;311(18):1901\u201311.","journal-title":"JAMA"},{"issue":"11","key":"263_CR2","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","volume":"121","author":"YC Tham","year":"2014","unstructured":"Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014;121(11):2081\u201390.","journal-title":"Ophthalmology"},{"key":"263_CR3","doi-asserted-by":"crossref","first-page":"6509809","DOI":"10.1155\/2016\/6509809","volume":"2016","author":"P Harasymowycz","year":"2016","unstructured":"Harasymowycz P, Birt C, Gooi P, Heckler L, Hutnik C, Jinapriya D, et al. Medical management of glaucoma in the 21st century from a Canadian perspective. J Ophthalmol. 2016;2016:6509809.","journal-title":"J Ophthalmol"},{"issue":"4","key":"263_CR4","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.preteyeres.2010.03.001","volume":"29","author":"C Baudouin","year":"2010","unstructured":"Baudouin C, Labbe A, Liang H, Pauly A, Brignole-Baudouin F. Preservatives in eyedrops: the good, the bad and the ugly. Prog Retin Eye Res. 2010;29(4):312\u201334.","journal-title":"Prog Retin Eye Res"},{"issue":"5","key":"263_CR5","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/IJG.0b013e31815c5f4f","volume":"17","author":"EW Leung","year":"2008","unstructured":"Leung EW, Medeiros FA, Weinreb RN. Prevalence of ocular surface disease in glaucoma patients. J Glaucoma. 2008;17(5):350\u20135.","journal-title":"J Glaucoma"},{"issue":"1","key":"263_CR6","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1080\/08820538.2016.1228406","volume":"32","author":"A Joseph","year":"2017","unstructured":"Joseph A, Pasquale LR. Attributes associated with adherence to glaucoma medical therapy and its effects on glaucoma outcomes: an evidence-based review and potential strategies to improve adherence. Semin Ophthalmol. 2017;32(1):86\u201390.","journal-title":"Semin Ophthalmol"},{"issue":"1","key":"263_CR7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ajo.2005.02.013","volume":"140","author":"HD Jampel","year":"2005","unstructured":"Jampel HD, Musch DC, Gillespie BW, Lichter PR, Wright MM, Guire KE, et al. Perioperative complications of trabeculectomy in the collaborative initial glaucoma treatment study (CIGTS). Am J Ophthalmol. 2005;140(1):16\u201322.","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"263_CR8","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.ajo.2011.10.024","volume":"153","author":"SJ Gedde","year":"2012","unstructured":"Gedde SJ, Herndon LW, Brandt JD, Budenz DL, Feuer WJ, Schiffman JC, et al. Postoperative complications in the Tube Versus Trabeculectomy (TVT) study during five years of follow-up. Am J Ophthalmol. 2012;153(5):804-14.e1.","journal-title":"Am J Ophthalmol"},{"issue":"12","key":"263_CR9","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1001\/jamaophthalmol.2013.5059","volume":"131","author":"E Rulli","year":"2013","unstructured":"Rulli E, Biagioli E, Riva I, Gambirasio G, De Simone I, Floriani I, et al. Efficacy and safety of trabeculectomy vs nonpenetrating surgical procedures: a systematic review and meta-analysis. JAMA Ophthalmol. 2013;131(12):1573\u201382.","journal-title":"JAMA Ophthalmol"},{"key":"263_CR10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2147\/OPTH.S239772","volume":"14","author":"JA Rosdahl","year":"2020","unstructured":"Rosdahl JA, Gupta D. Prospective studies of minimally invasive glaucoma surgeries: systematic review and quality assessment. Clin Ophthalmol. 2020;14:231\u201343.","journal-title":"Clin Ophthalmol"},{"key":"263_CR11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s40662-019-0154-1","volume":"6","author":"M Shah","year":"2019","unstructured":"Shah M. Micro-invasive glaucoma surgery\u2014an interventional glaucoma revolution. Eye Vis (Lond). 2019;6:29.","journal-title":"Eye Vis (Lond)"},{"issue":"2","key":"263_CR12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/ICU.0b013e32834ff1e7","volume":"23","author":"H Saheb","year":"2012","unstructured":"Saheb H, Ahmed II. Micro-invasive glaucoma surgery: current perspectives and future directions. Curr Opin Ophthalmol. 2012;23(2):96\u2013104.","journal-title":"Curr Opin Ophthalmol"},{"issue":"3","key":"263_CR13","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ophtha.2010.07.007","volume":"118","author":"TW Samuelson","year":"2011","unstructured":"Samuelson TW, Katz LJ, Wells JM, Duh YJ, Giamporcaro JE, US iStent Study Group. Randomized evaluation of the trabecular micro-bypass stent with phacoemulsification in patients with glaucoma and cataract. Ophthalmology. 2011;118(3):459\u201367.","journal-title":"Ophthalmology"},{"issue":"7","key":"263_CR14","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1167\/iovs.09-3972","volume":"51","author":"Y Fernandez-Barrientos","year":"2010","unstructured":"Fern\u00e1ndez-Barrientos Y, Garc\u00eda-Feijo\u00f3 J, Mart\u00ednez-de-la-Casa JM, Pablo LE, Fern\u00e1ndez-P\u00e9rez C, Garc\u00eda S\u00e1nchez J. Fluorophotometric study of the effect of the glaukos trabecular microbypass stent on aqueous humor dynamics. Invest Ophthalmol Vis Sci. 2010;51(7):3327\u201332.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"263_CR15","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ajo.2020.12.032","volume":"224","author":"A Salimi","year":"2021","unstructured":"Salimi A, Abu-Nada M, Harasymowycz P. Matched cohort study of cataract surgery with and without trabecular microbypass stent implantation in primary angle-closure glaucoma. Am J Ophthalmol. 2021;224:310\u201320.","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"263_CR16","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/IJG.0000000000001716","volume":"30","author":"A Salimi","year":"2021","unstructured":"Salimi A, Watt H, Harasymowycz P. Three-year outcomes of second-generation trabecular micro-bypass stents (iStent inject) with phacoemulsification in various glaucoma subtypes and severities. J Glaucoma. 2021;30(3):266\u201375.","journal-title":"J Glaucoma"},{"issue":"3","key":"263_CR17","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s40123-020-00266-6","volume":"9","author":"A Salimi","year":"2020","unstructured":"Salimi A, Clement C, Shiu M, Harasymowycz P. Second-generation trabecular micro-bypass (iStent inject) with cataract surgery in eyes with normal-tension glaucoma: one-year outcomes of a multi-centre study. Ophthalmol Ther. 2020;9(3):585\u201396.","journal-title":"Ophthalmol Ther"},{"issue":"4","key":"263_CR18","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s40123-019-00214-z","volume":"8","author":"A Salimi","year":"2019","unstructured":"Salimi A, Lapointe J, Harasymowycz P. One-year outcomes of second-generation trabecular micro-bypass stents (iStent Inject) implantation with cataract surgery in different glaucoma subtypes and severities. Ophthalmol Ther. 2019;8(4):563\u201375.","journal-title":"Ophthalmol Ther"},{"key":"263_CR19","doi-asserted-by":"crossref","first-page":"2731856","DOI":"10.1155\/2016\/2731856","volume":"2016","author":"AF Resende","year":"2016","unstructured":"Resende AF, Patel NS, Waisbourd M, Katz LJ. iStent\u00ae trabecular microbypass stent: an update. J Ophthalmol. 2016;2016:2731856.","journal-title":"J Ophthalmol"},{"issue":"4","key":"263_CR20","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1055\/s-0035-1545798","volume":"232","author":"M El Wardani","year":"2015","unstructured":"El Wardani M, Bergin C, Achache F, Sharkawi E. Evaluating the trabecular micro-bypass stent combined with phacoemulsification compared to phacoemulsification alone. Klin Monbl Augenheilkd. 2015;232(4):442\u20135.","journal-title":"Klin Monbl Augenheilkd"},{"issue":"8","key":"263_CR21","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.jcrs.2014.07.004","volume":"40","author":"II Ahmed","year":"2014","unstructured":"Ahmed II, Katz LJ, Chang DF, Donnenfeld ED, Solomon KD, Voskanyan L, et al. Prospective evaluation of microinvasive glaucoma surgery with trabecular microbypass stents and prostaglandin in open-angle glaucoma. J Cataract Refract Surg. 2014;40(8):1295\u2013300.","journal-title":"J Cataract Refract Surg"},{"key":"263_CR22","first-page":"875","volume":"8","author":"AM Fea","year":"2014","unstructured":"Fea AM, Belda JI, R\u0119kas M, J\u00fcnemann A, Chang L, Pablo L, et al. Prospective unmasked randomized evaluation of the iStent inject (\u00ae) versus two ocular hypotensive agents in patients with primary open-angle glaucoma. Clin Ophthalmol. 2014;8:875\u201382.","journal-title":"Clin Ophthalmol"},{"issue":"2","key":"263_CR23","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12325-014-0095-y","volume":"31","author":"L Voskanyan","year":"2014","unstructured":"Voskanyan L, Garc\u00eda-Feijo\u00f3 J, Belda JI, Fea A, J\u00fcnemann A, Baudouin C, et al. Prospective, unmasked evaluation of the iStent\u00ae inject system for open-angle glaucoma: synergy trial. Adv Ther. 2014;31(2):189\u2013201.","journal-title":"Adv Ther"},{"issue":"10","key":"263_CR24","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1136\/bjophthalmol-2012-302394","volume":"97","author":"P Arriola-Villalobos","year":"2013","unstructured":"Arriola-Villalobos P, Mart\u00ednez-de-la-Casa JM, D\u00edaz-Valle D, Garc\u00eda-Vidal SE, Fern\u00e1ndez-P\u00e9rez C, Garc\u00eda-S\u00e1nchez J, et al. Mid-term evaluation of the new Glaukos iStent with phacoemulsification in coexistent open-angle glaucoma or ocular hypertension and cataract. Br J Ophthalmol. 2013;97(10):1250\u20135.","journal-title":"Br J Ophthalmol"},{"issue":"7","key":"263_CR25","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/ceo.12098","volume":"41","author":"I Patel","year":"2013","unstructured":"Patel I, de Klerk TA, Au L. Manchester iStent study: early results from a prospective UK case series. Clin Exp Ophthalmol. 2013;41(7):648\u201352.","journal-title":"Clin Exp Ophthalmol"},{"issue":"11","key":"263_CR26","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1016\/j.jcrs.2012.07.017","volume":"38","author":"GW Belovay","year":"2012","unstructured":"Belovay GW, Naqi A, Chan BJ, Rateb M, Ahmed II. Using multiple trabecular micro-bypass stents in cataract patients to treat open-angle glaucoma. J Cataract Refract Surg. 2012;38(11):1911\u20137.","journal-title":"J Cataract Refract Surg"},{"issue":"8","key":"263_CR27","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.jcrs.2012.03.025","volume":"38","author":"ER Craven","year":"2012","unstructured":"Craven ER, Katz LJ, Wells JM, Giamporcaro JE, iStent Study Group. Cataract surgery with trabecular micro-bypass stent implantation in patients with mild-to-moderate open-angle glaucoma and cataract: two-year follow-up. J Cataract Refract Surg. 2012;38(8):1339\u201345.","journal-title":"J Cataract Refract Surg"},{"issue":"5","key":"263_CR28","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1136\/bjophthalmol-2011-300218","volume":"96","author":"P Arriola-Villalobos","year":"2012","unstructured":"Arriola-Villalobos P, Mart\u00ednez-de-la-Casa JM, D\u00edaz-Valle D, Fern\u00e1ndez-P\u00e9rez C, Garc\u00eda-S\u00e1nchez J, Garc\u00eda-Feijo\u00f3 J. Combined iStent trabecular micro-bypass stent implantation and phacoemulsification for coexistent open-angle glaucoma and cataract: a long-term study. Br J Ophthalmol. 2012;96(5):645\u20139.","journal-title":"Br J Ophthalmol"},{"key":"263_CR29","first-page":"321","volume":"5","author":"O Buchacra","year":"2011","unstructured":"Buchacra O, Duch S, Milla E, Stirbu O. One-year analysis of the iStent trabecular microbypass in secondary glaucoma. Clin Ophthalmol. 2011;5:321\u20136.","journal-title":"Clin Ophthalmol"},{"issue":"3","key":"263_CR30","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jcrs.2009.10.031","volume":"36","author":"AM Fea","year":"2010","unstructured":"Fea AM. Phacoemulsification versus phacoemulsification with micro-bypass stent implantation in primary open-angle glaucoma: randomized double-masked clinical trial. J Cataract Refract Surg. 2010;36(3):407\u201312.","journal-title":"J Cataract Refract Surg"},{"issue":"3","key":"263_CR31","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1177\/112067210901900311","volume":"19","author":"D Spiegel","year":"2009","unstructured":"Spiegel D, Wetzel W, Neuhann T, Stuermer J, Hoeh H, Garcia-Feijoo J, et al. Coexistent primary open-angle glaucoma and cataract: interim analysis of a trabecular micro-bypass stent and concurrent cataract surgery. Eur J Ophthalmol. 2009;19(3):393\u20139.","journal-title":"Eur J Ophthalmol"},{"issue":"5","key":"263_CR32","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s12325-008-0062-6","volume":"25","author":"D Spiegel","year":"2008","unstructured":"Spiegel D, Garc\u00eda-Feijo\u00f3 J, Garc\u00eda-S\u00e1nchez J, Lamielle H. Coexistent primary open-angle glaucoma and cataract: preliminary analysis of treatment by cataract surgery and the iStent trabecular micro-bypass stent. Adv Ther. 2008;25(5):453\u201364.","journal-title":"Adv Ther"},{"issue":"1","key":"263_CR33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF02850004","volume":"24","author":"D Spiegel","year":"2007","unstructured":"Spiegel D, Wetzel W, Haffner DS, Hill RA. Initial clinical experience with the trabecular micro-bypass stent in patients with glaucoma. Adv Ther. 2007;24(1):161\u201370.","journal-title":"Adv Ther"},{"issue":"7","key":"263_CR34","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1089\/jop.2019.0019","volume":"35","author":"A Salimi","year":"2019","unstructured":"Salimi A, Winter A, Li C, Harasymowycz P, Saheb H. Effect of topical corticosteroids on early postoperative intraocular pressure following combined cataract and trabecular microbypass surgery. J Ocul Pharmacol Ther. 2019;35(7):413\u201320.","journal-title":"J Ocul Pharmacol Ther"},{"issue":"6","key":"263_CR35","doi-asserted-by":"crossref","first-page":"e0252130","DOI":"10.1371\/journal.pone.0252130","volume":"16","author":"K Nieland","year":"2021","unstructured":"Nieland K, Labbe A, Schweitzer C, Gicquel G, Kleintjens J, Ostawal A, et al. A cost-effectiveness analysis of iStent inject combined with phacoemulsification cataract surgery in patients with mild-to-moderate open-angle glaucoma in France. PLoS One. 2021;16(6):e0252130.","journal-title":"PLoS One"},{"key":"263_CR36","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14906","author":"J Jablonska","year":"2021","unstructured":"Jab\u0142o\u0144ska J, Lewczuk K, Konopi\u0144ska J, Mariak Z, R\u0119kas M. Microinvasive glaucoma surgery: a review and classification of implant-dependent procedures and techniques. Acta Ophthalmol. 2021. https:\/\/doi.org\/10.1111\/aos.14906.","journal-title":"Acta Ophthalmol"},{"key":"263_CR37","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.2147\/OPTH.S302684","volume":"15","author":"RA Paletta Guedes","year":"2021","unstructured":"Paletta Guedes RA, Gravina DM, Paletta Guedes VM, Chaoubah A. Two-year comparative outcomes of first- and second-generation trabecular micro-bypass stents with cataract surgery. Clin Ophthalmol. 2021;15:1861\u201373.","journal-title":"Clin Ophthalmol"},{"issue":"1","key":"263_CR38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.17219\/acem\/129576","volume":"30","author":"M Kozera","year":"2021","unstructured":"Kozera M, Konopi\u0144ska J, R\u0119kas M. Mid-term evaluation of the safety and efficacy of the iStent trabecular micro-bypass system combined with phacoemulsification. Adv Clin Exp Med. 2021;30(1):49\u201354.","journal-title":"Adv Clin Exp Med"},{"key":"263_CR39","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.2147\/OPTH.S283587","volume":"14","author":"SRC Seixas","year":"2020","unstructured":"Silveira Seixas RC, Balbino M, Basile Neto A, de Alcantara Almeida Costa A, Jord\u00e3o MLDS, Russ HHA. Mid-term evaluation of iStent inject\u00ae trabecular micro-bypass stent implantation with or without phacoemulsification: a retrospective study. Clin Ophthalmol. 2020;14:4403\u201313.","journal-title":"Clin Ophthalmol"},{"key":"263_CR40","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.2147\/OPTH.S274281","volume":"14","author":"K Nitta","year":"2020","unstructured":"Nitta K, Yamada Y, Morokado S, Sugiyama K. iStent trabecular micro-bypass stent implantation with cataract surgery in a Japanese glaucoma population. Clin Ophthalmol. 2020;14:3381\u201391.","journal-title":"Clin Ophthalmol"},{"key":"263_CR41","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.2147\/OPTH.S249261","volume":"14","author":"A Al Habash","year":"2020","unstructured":"Al Habash A, Khan O. Outcomes of combined iStent trabecular micro-bypass and cataract surgery for the treatment of open-angle glaucoma in a Saudi population. Clin Ophthalmol. 2020;14:1573\u201380.","journal-title":"Clin Ophthalmol"},{"key":"263_CR42","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40662-020-00194-3","volume":"7","author":"TJ Ferguson","year":"2020","unstructured":"Ferguson TJ, Dockter Z, Bleeker A, Karpuk KL, Schweitzer J, Ibach MJ, et al. iStent inject trabecular microbypass stent implantation with cataract extraction in open-angle glaucoma: early clinical experience. Eye Vis (Lond). 2020;7:28.","journal-title":"Eye Vis (Lond)"},{"issue":"6","key":"263_CR43","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/ceo.13763","volume":"48","author":"J Berdahl","year":"2020","unstructured":"Berdahl J, Voskanyan L, Myers JS, Katz LJ, Samuelson TW. iStent inject trabecular micro-bypass stents with topical prostaglandin as standalone treatment for open-angle glaucoma: 4-year outcomes. Clin Exp Ophthalmol. 2020;48(6):767\u201374.","journal-title":"Clin Exp Ophthalmol"},{"key":"263_CR44","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2147\/OPTH.S235293","volume":"14","author":"R Lindstrom","year":"2020","unstructured":"Lindstrom R, Sarkisian SR, Lewis R, Hovanesian J, Voskanyan L. Four-year outcomes of two second-generation trabecular micro-bypass stents in patients with open-angle glaucoma on one medication. Clin Ophthalmol. 2020;14:71\u201380.","journal-title":"Clin Ophthalmol"},{"key":"263_CR45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40662-019-0169-7","volume":"7","author":"R Neuhann","year":"2020","unstructured":"Neuhann R, Neuhann T. Second-generation trabecular micro-bypass stent implantation: retrospective analysis after 12- and 24-month follow-up. Eye Vis (Lond). 2020;7:1.","journal-title":"Eye Vis (Lond)"},{"issue":"1","key":"263_CR46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/ceo.13638","volume":"48","author":"TJ Ferguson","year":"2020","unstructured":"Ferguson TJ, Ibach M, Schweitzer J, Karpuk KL, Stephens JD, Berdahl JP. Trabecular micro-bypass stent implantation with cataract extraction in pigmentary glaucoma. Clin Exp Ophthalmol. 2020;48(1):37\u201343.","journal-title":"Clin Exp Ophthalmol"},{"issue":"4","key":"263_CR47","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s40123-019-00208-x","volume":"8","author":"D Manning","year":"2019","unstructured":"Manning D. Real-world case series of iStent or iStent inject trabecular micro-bypass stents combined with cataract surgery. Ophthalmol Ther. 2019;8(4):549\u201361.","journal-title":"Ophthalmol Ther"},{"key":"263_CR48","doi-asserted-by":"crossref","unstructured":"Samuelson TW, Sarkisian SR Jr, Lubeck DM, Stiles MC, Duh YJ, Romo EA, et al. Prospective, randomized, controlled pivotal trial of an ab interno implanted trabecular micro-bypass in primary open-angle glaucoma and cataract: two-year results. Ophthalmology. 2019;126(6):811\u201321.","DOI":"10.1016\/j.ophtha.2019.03.006"},{"issue":"1","key":"263_CR49","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/IJG.0000000000000825","volume":"27","author":"T Ferguson","year":"2018","unstructured":"Ferguson T, Swan R, Ibach M, Schweitzer J, Sudhagoni R, Berdahl JP. Evaluation of a trabecular microbypass stent with cataract extraction in severe primary open-angle glaucoma. J Glaucoma. 2018;27(1):71\u20136.","journal-title":"J Glaucoma"},{"issue":"12","key":"263_CR50","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1016\/j.jcrs.2015.06.032","volume":"41","author":"TH Neuhann","year":"2015","unstructured":"Neuhann TH. Trabecular micro-bypass stent implantation during small-incision cataract surgery for open-angle glaucoma or ocular hypertension: long-term results. J Cataract Refract Surg. 2015;41(12):2664\u201371.","journal-title":"J Cataract Refract Surg"},{"key":"263_CR51","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.2147\/OPTH.S247910","volume":"14","author":"TJ Ferguson","year":"2020","unstructured":"Ferguson TJ, Mechels KB, Dockter Z, Bleeker A, Ibach M, Schweitzer J, et al. iStent trabecular microbypass stent implantation with phacoemulsification in patients with open-angle glaucoma: 6-year outcomes. Clin Ophthalmol. 2020;14:1859\u201366.","journal-title":"Clin Ophthalmol"},{"key":"263_CR52","doi-asserted-by":"crossref","unstructured":"Ziaei H, Au L. Manchester iStent study: long-term 7-year outcomes. Eye (Lond). 2020;35(8):2277\u201382.","DOI":"10.1038\/s41433-020-01255-6"},{"key":"263_CR53","doi-asserted-by":"crossref","unstructured":"Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, et al. The Lens Opacities Classification System III. The longitudinal study of cataract study group. Arch Ophthalmol. 1993;111(6):831\u20136.","DOI":"10.1001\/archopht.1993.01090060119035"},{"key":"263_CR54","unstructured":"Hodapp E, Parrish RK, Anderson DR. Clinical decisions in glaucoma: Mosby Incorporated; 1993."},{"issue":"11","key":"263_CR55","doi-asserted-by":"crossref","first-page":"7872","DOI":"10.1167\/iovs.11-7896","volume":"52","author":"JC Mwanza","year":"2011","unstructured":"Mwanza JC, Durbin MK, Budenz DL, Girkin CA, Leung CK, Liebmann JM, et al. Profile and predictors of normal ganglion cell-inner plexiform layer thickness measured with frequency-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2011;52(11):7872\u20139.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"263_CR56","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ogla.2020.08.014","volume":"4","author":"A Salimi","year":"2021","unstructured":"Salimi A, Nithianandan H, Al Farsi H, Harasymowycz P, Saheb H. Gonioscopy-assisted transluminal trabeculotomy in younger to middle-aged adults: one-year outcomes. Ophthalmol Glaucoma. 2021;4(2):162\u201372.","journal-title":"Ophthalmol Glaucoma"},{"issue":"11","key":"263_CR57","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1097\/IJG.0000000000001371","volume":"28","author":"A Salimi","year":"2019","unstructured":"Salimi A, Kovalyuk N, Harasymowycz PJ. Tube shunt revision with excision of fibrotic capsule using mitomycin c with and without ologen-a collagen matrix implant: a 3-year follow-up study. J Glaucoma. 2019;28(11):989\u201396.","journal-title":"J Glaucoma"},{"key":"263_CR58","first-page":"303728","volume":"2014","author":"M Wang","year":"2014","unstructured":"Wang M. Generalized estimating equations in longitudinal data analysis: a review and recent developments. Adv Stat. 2014;2014:303728.","journal-title":"Adv Stat"},{"issue":"3","key":"263_CR59","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s12325-018-0666-4","volume":"35","author":"JS Myers","year":"2018","unstructured":"Myers JS, Masood I, Hornbeak DM, Belda JI, Auffarth G, Junemann A, et al. Prospective evaluation of two iStent((R)) trabecular stents, one iStent supra((R)) suprachoroidal stent, and postoperative prostaglandin in refractory glaucoma: 4-year outcomes. Adv Ther. 2018;35(3):395\u2013407.","journal-title":"Adv Ther"},{"key":"263_CR60","first-page":"795357","volume":"2015","author":"AM Fea","year":"2015","unstructured":"Fea AM, Consolandi G, Zola M, Pignata G, Cannizzo P, Lavia C, et al. Micro-bypass implantation for primary open-angle glaucoma combined with phacoemulsification: 4-year follow-up. J Ophthalmol. 2015;2015:795357.","journal-title":"J Ophthalmol"},{"key":"263_CR61","first-page":"2057","volume":"9","author":"ED Donnenfeld","year":"2015","unstructured":"Donnenfeld ED, Solomon KD, Voskanyan L, Chang DF, Samuelson TW, Ahmed II, et al. A prospective 3-year follow-up trial of implantation of two trabecular microbypass stents in open-angle glaucoma. Clin Ophthalmol. 2015;9:2057\u201365.","journal-title":"Clin Ophthalmol"},{"key":"263_CR62","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2147\/OPTH.S121041","volume":"11","author":"DF Chang","year":"2017","unstructured":"Chang DF, Donnenfeld ED, Katz LJ, Voskanyan L, Ahmed II, Samuelson TW, et al. Efficacy of two trabecular micro-bypass stents combined with topical travoprost in open-angle glaucoma not controlled on two preoperative medications: 3-year follow-up. Clin Ophthalmol. 2017;11:523\u20138.","journal-title":"Clin Ophthalmol"},{"issue":"2","key":"263_CR63","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1080\/02713683.2020.1795881","volume":"46","author":"H Saheb","year":"2021","unstructured":"Saheb H, Donnenfeld ED, Solomon KD, Voskanyan L, Chang DF, Samuelson TW, et al. Five-year outcomes prospective study of two first-generation trabecular micro-bypass stents (iStent(R)) in open-angle glaucoma. Curr Eye Res. 2021;46(2):224\u201331.","journal-title":"Curr Eye Res"},{"issue":"3","key":"263_CR64","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jcrs.2018.10.029","volume":"45","author":"TH Neuhann","year":"2019","unstructured":"Neuhann TH, Hornbeak DM, Neuhann RT, Giamporcaro JE. Long-term effectiveness and safety of trabecular microbypass stent implantation with cataract surgery in patients with glaucoma or ocular hypertension: five-year outcomes. J Cataract Refract Surg. 2019;45(3):312\u201320.","journal-title":"J Cataract Refract Surg"},{"issue":"3","key":"263_CR65","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ogla.2019.03.004","volume":"2","author":"RD Fechtner","year":"2019","unstructured":"Fechtner RD, Voskanyan L, Vold SD, Tetz M, Auffarth G, Masood I, et al. Five-year, prospective, randomized, multi-surgeon trial of two trabecular bypass stents versus prostaglandin for newly diagnosed open-angle glaucoma. Ophthalmol Glaucoma. 2019;2(3):156\u201366.","journal-title":"Ophthalmol Glaucoma"},{"issue":"7","key":"263_CR66","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/IJG.0000000000000968","volume":"27","author":"CE Capitena Young","year":"2018","unstructured":"Capitena Young CE, Ammar DA, Seibold LK, Pantcheva MB, SooHoo JR, Kahook MY. Histopathologic examination of trabecular meshwork changes after trabecular bypass stent implantation. J Glaucoma. 2018;27(7):606\u20139.","journal-title":"J Glaucoma"},{"key":"263_CR67","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2147\/OPTH.S152268","volume":"12","author":"LJ Katz","year":"2018","unstructured":"Katz LJ, Erb C, Carceller Guillamet A, Fea AM, Voskanyan L, Giamporcaro JE, et al. Long-term titrated IOP control with one, two, or three trabecular micro-bypass stents in open-angle glaucoma subjects on topical hypotensive medication: 42-month outcomes. Clin Ophthalmol. 2018;12:255\u201362.","journal-title":"Clin Ophthalmol"},{"issue":"2","key":"263_CR68","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.exer.2010.12.010","volume":"92","author":"CR Hann","year":"2011","unstructured":"Hann CR, Bentley MD, Vercnocke A, Ritman EL, Fautsch MP. Imaging the aqueous humor outflow pathway in human eyes by three-dimensional micro-computed tomography (3D micro-CT). Exp Eye Res. 2011;92(2):104\u201311.","journal-title":"Exp Eye Res"},{"issue":"4","key":"263_CR69","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1167\/iovs.08-2375","volume":"50","author":"CR Hann","year":"2009","unstructured":"Hann CR, Fautsch MP. Preferential fluid flow in the human trabecular meshwork near collector channels. Invest Ophthalmol Vis Sci. 2009;50(4):1692\u20137.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"263_CR70","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1167\/iovs.08-1707","volume":"49","author":"SA Battista","year":"2008","unstructured":"Battista SA, Lu Z, Hofmann S, Freddo T, Overby DR, Gong H. Reduction of the available area for aqueous humor outflow and increase in meshwork herniations into collector channels following acute IOP elevation in bovine eyes. Invest Ophthalmol Vis Sci. 2008;49(12):5346\u201352.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"263_CR71","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.2147\/OPTH.S276124","volume":"14","author":"A Al Habash","year":"2020","unstructured":"Al Habash A, Nagshbandi AA. Quality of life after combined cataract and minimally invasive glaucoma surgery in glaucoma patients. Clin Ophthalmol. 2020;14:3049\u201356.","journal-title":"Clin Ophthalmol"},{"key":"263_CR72","first-page":"15","volume-title":"Guidelines on Design and Reporting of Glaucoma Surgical Trials: World Glaucoma Association","author":"DK Heuer","year":"2009","unstructured":"Heuer DK, Barton K, Grehn F, Shaarawy T, Sherwood M. Consensus on definition of success. In: Shaarway T, Sherwood M, Grehn F, editors. Guidelines on Design and Reporting of Glaucoma Surgical Trials: World Glaucoma Association. Amsterdam: Kluger Publications; 2009. p. 15\u201324."},{"issue":"10180","key":"263_CR73","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/S0140-6736(18)32213-X","volume":"393","author":"G Gazzard","year":"2019","unstructured":"Gazzard G, Konstantakopoulou E, Garway-Heath D, Garg A, Vickerstaff V, Hunter R, et al. Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial. Lancet. 2019;393(10180):1505\u201316.","journal-title":"Lancet"},{"issue":"1","key":"263_CR74","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/ICU.0b013e328332f562","volume":"21","author":"G Vizzeri","year":"2010","unstructured":"Vizzeri G, Weinreb RN. Cataract surgery and glaucoma. Curr Opin Ophthalmol. 2010;21(1):20\u20134.","journal-title":"Curr Opin Ophthalmol"},{"issue":"5","key":"263_CR75","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.jcrs.2007.12.045","volume":"34","author":"BJ Poley","year":"2008","unstructured":"Poley BJ, Lindstrom RL, Samuelson TW. Long-term effects of phacoemulsification with intraocular lens implantation in normotensive and ocular hypertensive eyes. J Cataract Refract Surg. 2008;34(5):735\u201342.","journal-title":"J Cataract Refract Surg"},{"issue":"7","key":"263_CR76","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0886-3350(99)00107-8","volume":"25","author":"BJ Shingleton","year":"1999","unstructured":"Shingleton BJ, Gamell LS, O\u2019Donoghue MW, Baylus SL, King R. Long-term changes in intraocular pressure after clear corneal phacoemulsification: normal patients versus glaucoma suspect and glaucoma patients. J Cataract Refract Surg. 1999;25(7):885\u201390.","journal-title":"J Cataract Refract Surg"},{"issue":"8","key":"263_CR77","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.ophtha.2010.12.035","volume":"118","author":"CK Leung","year":"2011","unstructured":"Leung CK, Liu S, Weinreb RN, Lai G, Ye C, Cheung CY, et al. Evaluation of retinal nerve fiber layer progression in glaucoma a prospective analysis with neuroretinal rim and visual field progression. Ophthalmology. 2011;118(8):1551\u20137.","journal-title":"Ophthalmology"}],"container-title":["Eye and Vision"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40662-021-00263-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40662-021-00263-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40662-021-00263-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T17:40:29Z","timestamp":1699810829000},"score":1,"resource":{"primary":{"URL":"https:\/\/eandv.biomedcentral.com\/articles\/10.1186\/s40662-021-00263-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,16]]},"references-count":77,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["263"],"URL":"https:\/\/doi.org\/10.1186\/s40662-021-00263-1","relation":{},"ISSN":["2326-0254"],"issn-type":[{"value":"2326-0254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,16]]},"assertion":[{"value":"2 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures were performed in accordance with the tenets of the Declaration of Helsinki. The study was approved by Ethics Committee of the H\u00f4pital Maisonneuve-Rosemont (Montreal, Canada) and was exempted from patient consent due to its retrospective nature.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All named authors met the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work in its entirety, and have given their approval for this version to be published.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Paul Harasymowycz is a consultant for Allergan, Alcon, Glaukos, Ivantis, J and J Vision, Santen, Novartis, and Bausch and Lomb.\u00a0Ali Salimi and Harrison Watt have nothing to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"43"}}