{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:41:52Z","timestamp":1793122912270,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 31370952"],"award-info":[{"award-number":["No. 31370952"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 31470914"],"award-info":[{"award-number":["No. 31470914"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 31600758"],"award-info":[{"award-number":["No. 31600758"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82171101"],"award-info":[{"award-number":["No.82171101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["Z181100006218099"],"award-info":[{"award-number":["Z181100006218099"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Open Research Fund from Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beijing Tongren Hospital, Beihang University & Capital Medical University","award":["BHTR-KFJJ-202001"],"award-info":[{"award-number":["BHTR-KFJJ-202001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eye and Vis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>To compare the dynamic corneal response (DCR) and tomographic parameters of thin normal cornea (TNC) with thinnest corneal thickness (TCT) (\u2264\u2009500\u00a0\u00b5m), forme\u00a0fruste keratoconus (FFKC) and mild keratoconus (MKC) had their central corneal thickness (CCT) matched by Scheimpflug imaging (Pentacam) and corneal visualization Scheimpflug technology (Corvis ST).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>CCT were matched in 50 eyes with FFKC, 50 eyes with MKC, and 53 TNC eyes with TCT\u2009\u2264\u2009500\u00a0\u00b5m. The differences in DCR and tomographic parameters among the three groups were compared. The receiver operating characteristic (ROC) curve was used to analyze the diagnostic significance of these parameters. Back propagation (BP) neural network was used to establish the keratoconus diagnosis model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Fifty CCT-matched FFKC eyes, 50 MKC eyes and 50 TNC eyes were included. The age and biomechanically corrected intraocular pressure (bIOP) did not differ significantly among the three groups (all <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). The index of height asymmetry (IHA) and height decentration (IHD) differed significantly among the three groups (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). IHD also had sufficient strength (area under the ROC curves (AUC)\u2009&gt;\u20090.80) to differentiate FFKC and MKC from TNC eyes. Partial DCR parameters showed significant differences between the MKC and TNC groups, and the deflection amplitude of the first applanation (A1DA) showed a good potential to differentiate (AUC\u2009&gt;\u20090.70) FFKC and MKC from TNC eyes. Diagnosis model by BP neural network showed an accurate diagnostic efficiency of about 91%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The majority of the tomographic and DCR parameters differed among the three groups. The IHD and partial DCR parameters assessed by Corvis ST distinguished FFKC and MKC from TNC when controlled for CCT.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40662-021-00266-y","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T10:02:56Z","timestamp":1637056976000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Comparisons of corneal biomechanical and tomographic parameters among thin normal cornea, forme\u00a0fruste keratoconus, and mild keratoconus"],"prefix":"10.1186","volume":"8","author":[{"given":"Lei","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9190-5475","authenticated-orcid":false,"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"issue":"4","key":"266_CR1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0039-6257(97)00119-7","volume":"42","author":"YS Rabinowitz","year":"1998","unstructured":"Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998;42(4):297\u2013319.","journal-title":"Surv Ophthalmol"},{"issue":"3","key":"266_CR2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jmbbm.2010.09.014","volume":"4","author":"R Ambekar","year":"2011","unstructured":"Ambekar R, Toussaint KC Jr, Wagoner JA. The effect of keratoconus on the structural, mechanical, and optical properties of the cornea. J Mech Behav Biomed Mater. 2011;4(3):223\u201336.","journal-title":"J Mech Behav Biomed Mater"},{"issue":"12","key":"266_CR3","doi-asserted-by":"publisher","first-page":"8377","DOI":"10.1167\/iovs.14-15348","volume":"55","author":"N Morishige","year":"2014","unstructured":"Morishige N, Shin-Gyou-Uchi R, Azumi H, Ohta H, Morita Y, Yamada N, et al. Quantitative analysis of collagen lamellae in the normal and keratoconic human cornea by second harmonic generation imaging microscopy. Invest Ophthalmol Vis Sci. 2014;55(12):8377\u201385.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"266_CR4","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.1167\/iovs.07-0968","volume":"49","author":"RL Niederer","year":"2008","unstructured":"Niederer RL, Perumal D, Sherwin T, McGhee CN. Laser scanning in vivo confocal microscopy reveals reduced innervation and reduction in cell density in all layers of the keratoconic cornea. Invest Ophthalmol Vis Sci. 2008;49(7):2964\u201370.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"266_CR5","doi-asserted-by":"publisher","first-page":"5557","DOI":"10.1167\/iovs.15-16926","volume":"56","author":"W Wang","year":"2015","unstructured":"Wang W, Du S, Zhang X. Corneal deformation response in patients with primary open-angle glaucoma and in healthy subjects analyzed by Corvis ST. Invest Ophthalmol Vis Sci. 2015;56(9):5557\u201365.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"266_CR6","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3928\/1081597X-20140422-01","volume":"30","author":"Y Shen","year":"2014","unstructured":"Shen Y, Chen Z, Knorz MC, Li M, Zhao J, Zhou X. Comparison of corneal deformation parameters after SMILE, LASEK, and femtosecond laser-assisted LASIK. J Refract Surg. 2014;30(5):310\u20138.","journal-title":"J Refract Surg"},{"issue":"6","key":"266_CR7","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.jcrs.2014.03.021","volume":"40","author":"DP Pi\u00f1ero","year":"2014","unstructured":"Pi\u00f1ero DP, Alc\u00f3n N. In vivo characterization of corneal biomechanics. J Cataract Refract Surg. 2014;40(6):870\u201387.","journal-title":"J Cataract Refract Surg"},{"issue":"1","key":"266_CR8","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1136\/bjophthalmol-2017-310355","volume":"102","author":"TC Chan","year":"2018","unstructured":"Chan TC, Wang YM, Yu M, Jhanji V. Comparison of corneal dynamic parameters and tomographic measurements using Scheimpflug imaging in keratoconus. Br J Ophthalmol. 2018;102(1):42\u20137.","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"266_CR9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12938-019-0636-3","volume":"18","author":"M J\u0119dzierowska","year":"2019","unstructured":"J\u0119dzierowska M, Koprowski R. Novel dynamic corneal response parameters in a practice use: a critical review. Biomed Eng Online. 2019;18(1):17.","journal-title":"Biomed Eng Online"},{"issue":"8","key":"266_CR10","doi-asserted-by":"publisher","first-page":"550","DOI":"10.3928\/1081597X-20160524-01","volume":"32","author":"R Vinciguerra","year":"2016","unstructured":"Vinciguerra R, Elsheikh A, Roberts CJ, Ambr\u00f3sio R Jr, Kang DS, Lopes BT, et al. Influence of pachymetry and intraocular pressure on dynamic corneal response parameters in healthy patients. J Refract Surg. 2016;32(8):550\u201361.","journal-title":"J Refract Surg"},{"issue":"2","key":"266_CR11","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.clae.2016.12.003","volume":"40","author":"W Wang","year":"2017","unstructured":"Wang W, He M, He H, Zhang C, Jin H, Zhong X. Corneal biomechanical metrics of healthy Chinese adults using Corvis ST. Cont Lens Anterior Eye. 2017;40(2):97\u2013103.","journal-title":"Cont Lens Anterior Eye"},{"issue":"3","key":"266_CR12","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.joco.2017.05.002","volume":"29","author":"R Elham","year":"2017","unstructured":"Elham R, Jafarzadehpur E, Hashemi H, Amanzadeh K, Shokrollahzadeh F, Yekta A, et al. Keratoconus diagnosis using Corvis ST measured biomechanical parameters. J Curr Ophthalmol. 2017;29(3):175\u201381.","journal-title":"J Curr Ophthalmol"},{"key":"266_CR13","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40662-020-0174-x","volume":"7","author":"LPG Esporcatte","year":"2020","unstructured":"Esporcatte LPG, Salom\u00e3o MQ, Lopes BT, Vinciguerra P, Vinciguerra R, Roberts C, et al. Biomechanical diagnostics of the cornea. Eye Vis (Lond). 2020;7:9.","journal-title":"Eye Vis (Lond)"},{"issue":"5","key":"266_CR14","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1177\/1120672118760146","volume":"28","author":"S Huseynli","year":"2018","unstructured":"Huseynli S, Salgado-Borges J, Alio JL. Comparative evaluation of Scheimpflug tomography parameters between thin non-keratoconic, subclinical keratoconic, and mild keratoconic corneas. Eur J Ophthalmol. 2018;28(5):521\u201334.","journal-title":"Eur J Ophthalmol"},{"issue":"1","key":"266_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/02713683.2013.798667","volume":"39","author":"E Zemova","year":"2014","unstructured":"Zemova E, Eppig T, Seitz B, Toropygin S, Arnold S, Langenbucher A, et al. Interaction between topographic\/tomographic parameters and dry eye disease in keratoconus patients. Curr Eye Res. 2014;39(1):1\u20138.","journal-title":"Curr Eye Res"},{"issue":"11","key":"266_CR16","doi-asserted-by":"publisher","first-page":"5546","DOI":"10.1167\/iovs.10-5369","volume":"51","author":"A Saad","year":"2010","unstructured":"Saad A, Gatinel D. Topographic and tomographic properties of forme fruste keratoconus corneas. Invest Ophthalmol Vis Sci. 2010;51(11):5546\u201355.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"266_CR17","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.jcrs.2010.12.049","volume":"37","author":"\u00d6\u00d6 U\u00e7akhan","year":"2011","unstructured":"U\u00e7akhan \u00d6\u00d6, \u00c7etinkor V, \u00d6zkan M, Kanpolat A. Evaluation of Scheimpflug imaging parameters in subclinical keratoconus, keratoconus, and normal eyes. J Cataract Refract Surg. 2011;37(6):1116\u201324.","journal-title":"J Cataract Refract Surg"},{"issue":"9","key":"266_CR18","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1016\/j.jcrs.2013.03.023","volume":"39","author":"O Muftuoglu","year":"2013","unstructured":"Muftuoglu O, Ayar O, Ozulken K, Ozyol E, Ak\u0131nc\u0131 A. Posterior corneal elevation and back difference corneal elevation in diagnosing forme fruste keratoconus in the fellow eyes of unilateral keratoconus patients. J Cataract Refract Surg. 2013;39(9):1348\u201357.","journal-title":"J Cataract Refract Surg"},{"issue":"3","key":"266_CR19","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.jbiomech.2015.12.031","volume":"49","author":"P Pe\u00f1a-Garc\u00eda","year":"2016","unstructured":"Pe\u00f1a-Garc\u00eda P, Peris-Mart\u00ednez C, Abbouda A, Ruiz-Moreno JM. Detection of subclinical keratoconus through non-contact tonometry and the use of discriminant biomechanical functions. J Biomech. 2016;49(3):353\u201363.","journal-title":"J Biomech"},{"key":"266_CR20","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.exer.2018.06.013","volume":"175","author":"A Eliasy","year":"2018","unstructured":"Eliasy A, Chen KJ, Vinciguerra R, Maklad O, Vinciguerra P, Ambr\u00f3sio R Jr, et al. Ex-vivo experimental validation of biomechanically-corrected intraocular pressure measurements on human eyes using the CorVis ST. Exp Eye Res. 2018;175:98\u2013102.","journal-title":"Exp Eye Res"},{"issue":"1","key":"266_CR21","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12886-020-01384-2","volume":"20","author":"D Fu","year":"2020","unstructured":"Fu D, Li M, Knorz MC, Wei S, Shang J, Zhou X. Intraocular pressure changes and corneal biomechanics after hyperopic small-incision lenticule extraction. BMC Ophthalmol. 2020;20(1):129.","journal-title":"BMC Ophthalmol"},{"issue":"3","key":"266_CR22","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1167\/tvst.8.3.48","volume":"8","author":"M Matsuura","year":"2019","unstructured":"Matsuura M, Murata H, Fujino Y, Yanagisawa M, Nakao Y, Nakakura S, et al. Repeatability of the novel intraocular pressure measurement from Corvis ST. Transl Vis Sci Technol. 2019;8(3):48.","journal-title":"Transl Vis Sci Technol"},{"issue":"4","key":"266_CR23","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.ophtha.2009.09.023","volume":"117","author":"BM Fontes","year":"2010","unstructured":"Fontes BM, Ambr\u00f3sio R Jr, Jardim D, Velarde GC, Nos\u00e9 W. Corneal biomechanical metrics and anterior segment parameters in mild keratoconus. Ophthalmology. 2010;117(4):673\u20139.","journal-title":"Ophthalmology"},{"issue":"6","key":"266_CR24","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.jcrs.2018.12.015","volume":"45","author":"R Herber","year":"2019","unstructured":"Herber R, Ramm L, Spoerl E, Raiskup F, Pillunat LE, Terai N. Assessment of corneal biomechanical parameters in healthy and keratoconic eyes using dynamic bidirectional applanation device and dynamic Scheimpflug analyzer. J Cataract Refract Surg. 2019;45(6):778\u201388.","journal-title":"J Cataract Refract Surg"},{"issue":"1","key":"266_CR25","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/cxo.12211","volume":"98","author":"HR Vellara","year":"2015","unstructured":"Vellara HR, Patel DV. Biomechanical properties of the keratoconic cornea: a review. Clin Exp Optom. 2015;98(1):31\u20138.","journal-title":"Clin Exp Optom"},{"issue":"10","key":"266_CR26","doi-asserted-by":"publisher","first-page":"e0140385","DOI":"10.1371\/journal.pone.0140385","volume":"10","author":"R Asaoka","year":"2015","unstructured":"Asaoka R, Nakakura S, Tabuchi H, Murata H, Nakao Y, Ihara N, et al. The relationship between Corvis ST tonometry measured corneal parameters and intraocular pressure, corneal thickness and corneal curvature. PLoS One. 2015;10(10):e0140385.","journal-title":"PLoS One"},{"issue":"5","key":"266_CR27","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.jcrs.2007.12.036","volume":"34","author":"Z Schlegel","year":"2008","unstructured":"Schlegel Z, Hoang-Xuan T, Gatinel D. Comparison of and correlation between anterior and posterior corneal elevation maps in normal eyes and keratoconus-suspect eyes. J Cataract Refract Surg. 2008;34(5):789\u201395.","journal-title":"J Cataract Refract Surg"},{"issue":"2","key":"266_CR28","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1097\/ICO.0000000000002129","volume":"39","author":"S Koh","year":"2020","unstructured":"Koh S, Inoue R, Ambr\u00f3sio R Jr, Maeda N, Miki A, Nishida K. Correlation between corneal biomechanical indices and the severity of keratoconus. Cornea. 2020;39(2):215\u201321.","journal-title":"Cornea"},{"issue":"7","key":"266_CR29","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1097\/OPX.0000000000001241","volume":"95","author":"S Catal\u00e1n-L\u00f3pez","year":"2018","unstructured":"Catal\u00e1n-L\u00f3pez S, Cadarso-Su\u00e1rez L, L\u00f3pez-Rat\u00f3n M, Cadarso-Su\u00e1rez C. Corneal biomechanics in unilateral keratoconus and fellow eyes with a Scheimpflug-based tonometer. Optom Vis Sci. 2018;95(7):608\u201315.","journal-title":"Optom Vis Sci"},{"key":"266_CR30","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s40662-016-0048-4","volume":"3","author":"F Bao","year":"2016","unstructured":"Bao F, Geraghty B, Wang Q, Elsheikh A. Consideration of corneal biomechanics in the diagnosis and management of keratoconus: is it important? Eye Vis (Lond). 2016;3:18.","journal-title":"Eye Vis (Lond)"},{"issue":"2","key":"266_CR31","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1111\/opo.12768","volume":"41","author":"A Alvani","year":"2021","unstructured":"Alvani A, Hashemi H, Pakravan M, Mahbod M, Amanzadeh K, Seyedian MA, et al. Dynamic corneal biomechanics in different cell layers: in keratoconus and normal eyes. Ophthalmic Physiol Opt. 2021;41(2):414\u201323.","journal-title":"Ophthalmic Physiol Opt"},{"issue":"7","key":"266_CR32","doi-asserted-by":"publisher","first-page":"4490","DOI":"10.1167\/iovs.14-14450","volume":"55","author":"G Scarcelli","year":"2014","unstructured":"Scarcelli G, Besner S, Pineda R, Yun SH. Biomechanical characterization of keratoconus corneas ex vivo with Brillouin microscopy. Invest Ophthalmol Vis Sci. 2014;55(7):4490\u20135.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"266_CR33","first-page":"881","volume":"51","author":"Y Wu","year":"2019","unstructured":"Wu Y, Li XL, Yang SL, Yan XM, Li HL. Examination and discriminant analysis of corneal biomechanics with CorVis ST in keratoconus and subclinical keratoconus. Beijing Da Xue Xue Bao Yi Xue Ban. 2019;51(5):881\u20136.","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"issue":"12","key":"266_CR34","doi-asserted-by":"publisher","first-page":"803","DOI":"10.3928\/1081597X-20160629-01","volume":"32","author":"R Vinciguerra","year":"2016","unstructured":"Vinciguerra R, Ambr\u00f3sio R Jr, Elsheikh A, Roberts CJ, Lopes B, Morenghi E, et al. Detection of keratoconus with a new biomechanical index. J Refract Surg. 2016;32(12):803\u201310.","journal-title":"J Refract Surg"},{"issue":"6","key":"266_CR35","doi-asserted-by":"publisher","first-page":"399","DOI":"10.3928\/1081597X-20170213-01","volume":"33","author":"R Vinciguerra","year":"2017","unstructured":"Vinciguerra R, Ambr\u00f3sio R Jr, Roberts CJ, Azzolini C, Vinciguerra P. Biomechanical characterization of subclinical keratoconus without topographic or tomographic abnormalities. J Refract Surg. 2017;33(6):399\u2013407.","journal-title":"J Refract Surg"},{"issue":"10","key":"266_CR36","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.jcrs.2017.10.012","volume":"43","author":"M Francis","year":"2017","unstructured":"Francis M, Pahuja N, Shroff R, Gowda R, Matalia H, Shetty R, et al. Waveform analysis of deformation amplitude and deflection amplitude in normal, suspect, and keratoconic eyes. J Cataract Refract Surg. 2017;43(10):1271\u201380.","journal-title":"J Cataract Refract Surg"},{"issue":"1","key":"266_CR37","doi-asserted-by":"publisher","first-page":"3041","DOI":"10.1038\/s41598-020-80915-9","volume":"11","author":"X Wang","year":"2021","unstructured":"Wang X, McAlinden C, Zhang H, Yan J, Wang D, Wei W, et al. Assessment of corneal biomechanics, tonometry and pachymetry with the Corvis ST in myopia. Sci Rep. 2021;11(1):3041.","journal-title":"Sci Rep"},{"issue":"6","key":"266_CR38","doi-asserted-by":"publisher","first-page":"3651","DOI":"10.1167\/iovs.13-13715","volume":"55","author":"NQ Ali","year":"2014","unstructured":"Ali NQ, Patel DV, McGhee CN. Biomechanical responses of healthy and keratoconic corneas measured using a noncontact Scheimpflug-based tonometer. Invest Ophthalmol Vis Sci. 2014;55(6):3651\u20139.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"266_CR39","first-page":"911","volume":"55","author":"HH Zou","year":"2019","unstructured":"Zou HH, Xu JH, Zhang L, Ji SF, Wang Y. Assistant diagnose for subclinical keratoconus by artificial intelligence. Zhonghua Yan Ke Za Zhi. 2019;55(12):911\u20135.","journal-title":"Zhonghua Yan Ke Za Zhi"},{"issue":"6","key":"266_CR40","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1097\/ICO.0000000000001194","volume":"36","author":"I Ruiz Hidalgo","year":"2017","unstructured":"Ruiz Hidalgo I, Rozema JJ, Saad A, Gatinel D, Rodriguez P, Zakaria N, et al. Validation of an objective keratoconus detection system implemented in a Scheimpflug tomographer and comparison with other methods. Cornea. 2017;36(6):689\u201395.","journal-title":"Cornea"}],"container-title":["Eye and Vision"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40662-021-00266-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40662-021-00266-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40662-021-00266-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T10:06:11Z","timestamp":1637057171000},"score":1,"resource":{"primary":{"URL":"https:\/\/eandv.biomedcentral.com\/articles\/10.1186\/s40662-021-00266-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,16]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["266"],"URL":"https:\/\/doi.org\/10.1186\/s40662-021-00266-y","relation":{},"ISSN":["2326-0254"],"issn-type":[{"value":"2326-0254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,16]]},"assertion":[{"value":"29 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was granted for this study by\u00a0Ethics Committee of the Beijing Tongren Hospital (20180120), all participants gave informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that there is no conflict of interests regarding the publication of this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"44"}}