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The goal of this study was to compare the surgical outcomes after DMEK in FECD patients with subclinical corneal edema and clinical corneal edema to test the hypothesis of whether performing surgery in subclinical corneal edema stages achieves better surgical outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>In this prospective, observational, single-institution cohort study, 106 pseudophakic eyes of 85 patients with FECD were divided into two groups depending on the presence of preoperative subclinical and clinical corneal edema. Subclinical corneal edema was diagnosed if more than one of the following criteria was present in Scheimpflug tomography: loss of regular isopachs, displacement of the thinnest point of the cornea, and focal posterior corneal surface depression. Clinical corneal edema was diagnosed with slit-lamp biomicroscopy. The primary outcome was the corrected distance visual acuity (CDVA) 4\u00a0months after DMEK. Secondary outcomes were central corneal thickness (CCT), thinnest corneal thickness (TCT), and total corneal density (TCD) in Scheimpflug tomography, as well as endothelial cell loss (ECL) and the re-bubbling rate. The differences between both groups were analyzed using clustered Wilcoxon rank-sum tests or a Chi-squared test.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Postoperative CDVA was significantly better in the group with subclinical edema (0.18\u2009\u00b1\u20090.12 logMAR) compared to the group with clinical edema (0.24\u2009\u00b1\u20090.19 logMAR; <jats:italic>P<\/jats:italic>\u2009=\u20090.026). Four months after DMEK, TCD was higher in the group with preoperative clinical edema [31.7\u2009\u00b1\u20098.3\u00a0gray scale units (GSU)] compared to the group with subclinical edema (27.8\u2009\u00b1\u20096.1 GSU; <jats:italic>P<\/jats:italic>\u2009=\u20090.005). The postoperative CCT, TCT, ECL, and re-bubbling rates did not differ significantly between both groups (all <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>DMEK for FECD yielded better visual acuity after 4\u00a0months when performed in the early stage of FECD compared to a later stage with clinical edema. This may be attributable to persistent corneal fibrosis after DMEK in eyes with preoperative clinically evident corneal edema, as suggested by higher postoperative corneal density in eyes with clinical edema. Consequently, the findings advocate for the consideration of earlier DMEK in FECD patients to achieve better surgical recovery.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s40662-025-00425-5","type":"journal-article","created":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:02:20Z","timestamp":1740787340000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Preoperative edema severity affects outcomes after Descemet membrane endothelial keratoplasty for Fuchs endothelial corneal dystrophy: a cohort study"],"prefix":"10.1186","volume":"12","author":[{"given":"Maximilian","family":"Friedrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeck-Soo","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Lind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizaveta","family":"Chychko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timur Mert","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd Uwe","family":"Auffarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Aristide","family":"Augustin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,1]]},"reference":[{"issue":"3","key":"425_CR1","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1097\/ICO.0000000000003420","volume":"43","author":"JS Weiss","year":"2024","unstructured":"Weiss JS, Rapuano CJ, Seitz B, Busin M, Kivel\u00e4 TT, Bouheraoua N, et al. 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Informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"T.M. Yildirim reports lecture fees from Alcon Laboratories, Johnson & Johnson Vision and Hoya Corp. and nonfinancial support from Johnson & Johnson Vision. G.U. Auffarth reports lecture fees and research grants from Johnson & Johnson Vision, Alcon Laboratories, Carl Zeiss Meditec AG, Hoya Corp., Kowa Co., Ltd., Oculentis GmbH\/Teleon, Physiol S.A., Rayner Intraocular Lenses Ltd., Oculus Optikger\u00e4te GmbH, Ophthec BV, Santen, Sifi Medtech Srl, Acufocus Inc., Novartis, Ursapharm and Biotech; nonfinancial support from Rheacell, Contamac, Cristalens, Croma, EyeYon, Hanita, and VSY outside the submitted work. V. A. Augustin reports research grants from Kowa Co. outside the submitted work. The remaining authors have no conflicts to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9"}}