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First, the measurement performance was examined across two SS-OCT systems (CASIA2 and VG200D) and four scanning modes (R1, R8, R16, and R64) by comparing the DIC-derived displacements with the simulated ground-truth fields. Second, reliability was validated using a \u201ccross-image\u201d strategy, in which artificial deformations were applied to biological images to assess tracking accuracy under realistic speckle noise. Third, 23 subjects were recruited and divided into three groups: control group (CN, n\u2009=\u20097), high myopia group (HM, n\u2009=\u20097), and elderly group (n\u2009=\u20099). Macroscopic morphological parameters (anterior CM length change and maximum CM thickness change) and biomechanical parameters (e.g., equivalent strain) were extracted synchronously.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The R8 scanning mode in the CASIA2 device exhibited the most stable acquisition configuration. The robustness of the ncorr\u2011DIC algorithm was verified through the second-step experiment. Under the accommodative stimulus of\u2009\u2212\u20095.0 D, the effective strain exhibited a highly significant graded attenuation among groups: CN (0.28\u2009\u00b1\u20090.06)\u2009&gt;\u2009HM (0.20\u2009\u00b1\u20090.03)\u2009&gt;\u2009Elderly (0.16\u2009\u00b1\u20090.05) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002). Morphological changes were consistent with this finding, and CM thickening was significantly greater in the CN group than in the other two groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003). Combined analysis revealed that the mean effective strain was not only significantly positively correlated with macroscopic muscle thickening (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.70,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) but was also highly correlated with accommodation amplitude (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.69,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DIC-based OCT analysis is feasible for assessing the biomechanical response of CM. By quantifying mechanical attenuation associated with HM and age-related decline, this method provides a new functional biomarker for investigating the mechanisms of accommodation dysfunction and guiding clinical interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40662-026-00498-w","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:11:43Z","timestamp":1783296703000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In vivo biomechanical property detection of the ciliary muscle based on optical coherence tomography and digital image correlation technology"],"prefix":"10.1186","volume":"13","author":[{"given":"Jingsong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenao","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"498_CR1","unstructured":"vH H. 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