{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:08:55Z","timestamp":1781856535830,"version":"3.54.5"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Implant Dent"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to compare the healing of the augmented sinus at which the antrostomy was covered with a membrane or the repositioned bone plate.<\/jats:p><jats:p>Eight sheep underwent bilateral maxillary sinus floor augmentation. The control site was covered with a resorbable membrane, while at the experimental site the bone plate was repositioned, and both were secured with cyanoacrylate. Animals were euthanised after 4\u2009months and histomorphometric analysis was performed.<\/jats:p><jats:p>A large amount of the graft appeared to be partially interpenetrated by the newly formed bone. Statistical analysis demonstrated different percentages of the new bone and bone interpenetrated to the graft between test and control site in the close-to-window area respectively 22.1 \u00b1 12.6 vs 7.5 \u00b1 4.5 (<jats:italic>P<\/jats:italic>= 0.028) and 66.1 \u00b1 14.7 vs 44.2 \u00b1 15.1 (<jats:italic>P<\/jats:italic>= 0.046). Other areas showed no difference in the bone and graft amount. More bone was found at the edges of the antrostomy in the experimental site, without statistical significance. In the centre of the antrostomy, the replaced bony window appeared bonded to the newly formed bone. No remnants and no biological response to cyanoacrylate were observed.<\/jats:p><jats:p>The repositioning of the bony window after sinus floor elevation in sheep led to a larger amount of newly formed bone in the close-to-window zone of the grafted area. The bony window appeared partially bonded to the new bone. Newly formed bone was found interpenetrating the graft granules.<\/jats:p>","DOI":"10.1186\/s40729-020-0207-1","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:04:34Z","timestamp":1584489874000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Bone plate repositioned over the antrostomy after sinus floor elevation: an experimental study in sheep"],"prefix":"10.1186","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2802-4058","authenticated-orcid":false,"given":"Alessandro","family":"Perini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Ferrante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Sivolella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn Urbizo","family":"Velez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Bengazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Botticelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"207_CR1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0011-8532(22)02464-8","volume":"36","author":"H Tatum Jr","year":"1992","unstructured":"Tatum H Jr. Maxillary sinus grafting for endosseous implants. Lecture presented at the Annual Meeting of the Alabama Implant Study Group (1977); cited in Smiler DG, Johnson PW, Lozada JL, Misch C, Rosenlicht JL, Tatum OH Jr., Wagner JR. Sinus lift grafts and endosseous implants. Treatment of the atrophic posterior maxilla. Dent Clin North Am. 1992;36:151\u201386.","journal-title":"Dent Clin North Am."},{"key":"207_CR2","first-page":"613","volume":"38","author":"PJ Boyne","year":"1980","unstructured":"Boyne PJ, James RA. Grafting of the maxillary sinus floor with autogenous marrow and bone. J Oral Surg. 1980;38:613\u20136.","journal-title":"J Oral Surg."},{"issue":"6","key":"207_CR3","first-page":"760","volume":"11","author":"S Lundgren","year":"1996","unstructured":"Lundgren S, Moy P, Johansson C, Nilsson H. Augmentation of the maxillary sinus floor with particulated mandible: a histologic and histomorphometric study. Int J Oral Maxillofac Implants. 1996 Nov\u2013Dec;11(6):760\u20136.","journal-title":"Int J Oral Maxillofac Implants."},{"issue":"5","key":"207_CR4","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1034\/j.1600-0501.2001.120511.x","volume":"12","author":"GM Raghoebar","year":"2001","unstructured":"Raghoebar GM, Louwerse C, Kalk WW, Vissink A. Morbidity of chin bone harvesting. Clin Oral Implants Res. 2001 Oct;12(5):503\u20137.","journal-title":"Clin Oral Implants Res."},{"issue":"3","key":"207_CR5","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1708-8208.2003.tb00197.x","volume":"5","author":"J Clavero","year":"2003","unstructured":"Clavero J, Lundgren S. Ramus or chin grafts for maxillary sinus inlay and local onlay augmentation: comparison of donor site morbidity and complications. Clin Implant Dent Relat Res. 2003;5(3):154\u201360.","journal-title":"Clin Implant Dent Relat Res."},{"key":"207_CR6","first-page":"107","volume-title":"The sinus bone graft","author":"JF Tulasnc","year":"1999","unstructured":"Tulasnc JF. Sinus grafting with calvarial bone. In: Jensen OT, editor. The sinus bone graft. Chicago: Quintessence; 1999. p. 107\u201316."},{"issue":"5","key":"207_CR7","first-page":"635","volume":"17","author":"M Hallman","year":"2002","unstructured":"Hallman M, Sennerby L, Lundgren S. A clinical and histologic evaluation of implant integration in the posterior maxilla after sinus floor augmentation with autogenous bone, bovine hydroxyapatite, or a 20:80 mixture. Int J Oral Maxillofac Implants. 2002 Sep\u2013Oct;17(5):635\u201343.","journal-title":"Int J Oral Maxillofac Implants."},{"issue":"1","key":"207_CR8","first-page":"23","volume":"16","author":"M Yildirim","year":"2001","unstructured":"Yildirim M, Spiekermann H, Handt S, Edelhoff D. Maxillary sinus augmentation with the xenograft Bio-Oss and autogenous intraoral bone for qualitative improvement of the implant site: a histologic and histomorphometric clinical study in humans. Int J Oral Maxillofac Implants. 2001 Jan\u2013Feb;16(1):23\u201333.","journal-title":"Int J Oral Maxillofac Implants."},{"issue":"3","key":"207_CR9","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1708-8208.2004.tb00224.x","volume":"6","author":"S Lundgren","year":"2004","unstructured":"Lundgren S, Andersson S, Gualini F, Sennerby L. Bone reformation with sinus membrane elevation: a new surgical technique for maxillary sinus floor augmentation. Clin Implant Dent Relat Res. 2004;6(3):165\u201373.","journal-title":"Clin Implant Dent Relat Res."},{"issue":"8 Suppl","key":"207_CR10","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/j.1600-051X.2008.01272.x","volume":"35","author":"BE Pjetursson","year":"2008","unstructured":"Pjetursson BE, Tan WC, Zwahlen M, Lang NP. A systematic review of the success of sinus floor elevation and survival of implants inserted in combination with sinus floor elevation. J Clin Periodontol. 2008 Sep;35(8 Suppl):216\u201340.","journal-title":"J Clin Periodontol."},{"key":"207_CR11","first-page":"26","volume":"1","author":"Y Nosaka","year":"2015","unstructured":"Nosaka Y, Nosaka H, Arai Y. Complications of postoperative swelling of the maxillary sinus membrane after sinus floor augmentation. J Oral Sci Rehab. 2015;1:26\u201333.","journal-title":"J Oral Sci Rehab."},{"issue":"4","key":"207_CR12","doi-asserted-by":"publisher","first-page":"827","DOI":"10.11607\/jomi.4570","volume":"31","author":"G Tawil","year":"2016","unstructured":"Tawil G, Tawil P, Khairallah A. Sinus floor elevation using the lateral approach and bone window repositioning I: clinical and radiographic results in 102 consecutively treated patients followed from 1 to 5 years. Int J Oral Maxillofac Implants. 2016 Jul\u2013Aug;31(4):827\u201334.","journal-title":"Int J Oral Maxillofac Implants."},{"issue":"5","key":"207_CR13","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.11607\/jomi.6226","volume":"33","author":"G Tawil","year":"2018","unstructured":"Tawil G, Barbeck M, Unger R, Tawil P, Witte F. Sinus floor elevation using the lateral approach and window repositioning and a xenogeneic bone substitute as a grafting material: a histologic, histomorphometric, and radiographic analysis. Int J Oral Maxillofac Implants. 2018 Sep\u2013Oct;33(5):1089\u201396.","journal-title":"Int J Oral Maxillofac Implants."},{"issue":"1","key":"207_CR14","first-page":"14","volume":"20","author":"E Juzikis","year":"2018","unstructured":"Juzikis E, Gaubys A, Rusilas H. Uses of maxillary sinus lateral wall bony window in an open window sinus lift procedure: literature review. Stomatologija. 2018;20(1):14\u201321 Review.","journal-title":"Stomatologija."},{"issue":"3","key":"207_CR15","doi-asserted-by":"publisher","first-page":"607","DOI":"10.11607\/jomi.3886","volume":"30","author":"F Su\u00e1rez-L\u00f3pez Del Amo","year":"2015","unstructured":"Su\u00e1rez-L\u00f3pez Del Amo F, Ortega-Oller I, Catena A, Monje A, Khoshkam V, Torrecillas-Mart\u00ednez L, Wang HL, Galindo-Moreno P. Effect of barrier membranes on the outcomes of maxillary sinus floor augmentation: a meta-analysis of histomorphometric outcomes. Int J Oral Maxillofac Implants. 2015 May\u2013Jun;30(3):607\u201318.","journal-title":"Int J Oral Maxillofac Implants."},{"issue":"1","key":"207_CR16","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1097\/ID.0000000000000031","volume":"23","author":"YS Moon","year":"2014","unstructured":"Moon YS, Sohn DS, Moon JW, Lee JH, Park IS, Lee JK. Comparative histomorphometric analysis of maxillary sinus augmentation with absorbable collagen membrane and osteoinductive replaceable bony window in rabbits. Implant Dent. 2014 Feb;23(1):29\u201336.","journal-title":"Implant Dent."},{"issue":"8","key":"207_CR17","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1111\/clr.13292","volume":"29","author":"Y Omori","year":"2018","unstructured":"Omori Y, Ricardo Silva E, Botticelli D, Apaza Alccayhuaman KA, Lang NP, Xavier SP. Reposition of the bone plate over the antrostomy in maxillary sinus augmentation: a histomorphometric study in rabbits. Clin Oral Implants Res. 2018 Aug;29(8):821\u201334.","journal-title":"Clin Oral Implants Res."},{"issue":"1","key":"207_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.joms.2012.09.002","volume":"71","author":"WM De Melo","year":"2013","unstructured":"De Melo WM, Maximiano WM, Antunes AA, Beloti MM, Rosa AL, de Oliveira PT. Cytotoxicity testing of methyl and ethyl 2-cyanoacrylate using direct contact assay on osteoblast cell cultures. J Oral Maxillofac Surg. 2013 Jan;71(1):35\u201341.","journal-title":"J Oral Maxillofac Surg."},{"issue":"2","key":"207_CR19","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s10006-015-0541-2","volume":"20","author":"S Vieira Jde","year":"2016","unstructured":"Vieira Jde S, Santos FR, de Freitas JV, Baratto-Filho F, Gonzaga CC, de Araujo MR. Bond strength evaluation of cyanoacrylate-based adhesives and screws for bone fixation. Oral Maxillofac Surg. 2016 Jun;20(2):157\u201360.","journal-title":"Oral Maxillofac Surg."},{"key":"207_CR20","volume-title":"The principles of human experimental technique","author":"WMS Russell","year":"1959","unstructured":"Russell WMS, Burch RL. The principles of human experimental technique. London: Methuen; 1959."},{"issue":"3","key":"207_CR21","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/j.1365-2818.1973.tb04629.x","volume":"99","author":"HE Schroeder","year":"1973","unstructured":"Schroeder HE, M\u00fcnzel-Pedrazzoli S. Correlated morphometric and biochemical analysis of gingival tissue: morphometric model, tissue sampling and test of stereologic procedures. J Microsc. 1973 Dec;99(3):301\u201329.","journal-title":"J Microsc."},{"issue":"3","key":"207_CR22","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1097\/ID.0b013e3181df1406","volume":"19","author":"DS Sohn","year":"2010","unstructured":"Sohn DS, Kim WS, An KM, Song KJ, Lee JM, Mun YS. Comparative histomorphometric analysis of maxillary sinus augmentation with and without bone grafting in rabbit. Implant Dent. 2010 Jun;19(3):259\u201370.","journal-title":"Implant Dent."},{"issue":"5","key":"207_CR23","first-page":"1033","volume":"26","author":"DS Sohn","year":"2011","unstructured":"Sohn DS, Moon JW, Lee WH, Kim SS, Kim CW, Kim KT, Moon YS. Comparison of new bone formation in the maxillary sinus with and without bone grafts: immunochemical rabbit study. Int J Oral Maxillofac Implants. 2011 Sep\u2013Oct;26(5):1033\u201342.","journal-title":"Int J Oral Maxillofac Implants."},{"issue":"2","key":"207_CR24","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/clr.12576","volume":"27","author":"V Favero","year":"2016","unstructured":"Favero V, Lang NP, Canullo L, Urbizo Velez J, Bengazi F, Botticelli D. Sinus floor elevation outcomes following perforation of the Schneiderian membrane: an experimental study in sheep. Clin Oral Implants Res. 2016 Feb;27(2):233\u201340.","journal-title":"Clin Oral Implants Res."},{"issue":"15","key":"207_CR25","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/S0142-9612(97)00036-7","volume":"18","author":"S Yamada","year":"1997","unstructured":"Yamada S, Heymann D, Bouler JM, Daculsi G. Osteoclastic resorption of calcium phosphate ceramics with different hydroxyapatite\/beta-tricalcium phosphate ratios. Biomaterials. 1997 Aug;18(15):1037\u201341.","journal-title":"Biomaterials."},{"issue":"1","key":"207_CR26","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/jbm.a.32354","volume":"92","author":"S Nakamura","year":"2010","unstructured":"Nakamura S, Kobayashi T, Nakamura M, Itoh S, Yamashita K. Electrostatic surface charge acceleration of bone ingrowth of porous hydroxyapatite\/beta-tricalcium phosphate ceramics. J Biomed Mater Res A. 2010 Jan;92(1):267\u201375.","journal-title":"J Biomed Mater Res A."},{"issue":"11","key":"207_CR27","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1111\/clr.12762","volume":"27","author":"A Scala","year":"2016","unstructured":"Scala A, Lang NP, Velez JU, Favero R, Bengazi F, Botticelli D. Effects of a collagen membrane positioned between augmentation material and the sinus mucosa in the elevation of the maxillary sinus floor: an experimental study in sheep. Clin Oral Implants Res. 2016 Nov;27(11):1454\u201361.","journal-title":"Clin Oral Implants Res."},{"issue":"12","key":"207_CR28","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1111\/j.1600-0501.2010.01964.x","volume":"21","author":"A Scala","year":"2010","unstructured":"Scala A, Botticelli D, Rangel IG Jr, de Oliveira JA, Okamoto R, Lang NP. Early healing after elevation of the maxillary sinus floor applying a lateral access: a histological study in monkeys. Clin Oral Implants Res. 2010 Dec;21(12):1320\u20136.","journal-title":"Clin Oral Implants Res."},{"key":"207_CR29","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1111\/clr.12850","volume":"28","author":"M Caneva","year":"2017","unstructured":"Caneva M, Lang NP, Garcia Rangel IJ, Ferreira S, Caneva M, De Santis E, Botticelli D. Sinus mucosa elevation using Bio-Oss\u00ae or Gingistat\u00ae collagen sponge: an experimental study in rabbits. Clin Oral Implants Res. 2017;28:e21\u201330.","journal-title":"Clin Oral Implants Res."},{"issue":"12","key":"207_CR30","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1111\/clr.13027","volume":"28","author":"T Iida","year":"2017","unstructured":"Iida T. Carneiro Martins Neto E, Botticelli D, Apaza Alccayhuaman KA, Lang NP, Xavier SP. Influence of a collagen membrane positioned subjacent the sinus mucosa following the elevation of the maxillary sinus: a histomorphometric study in rabbits. Clin Oral Implants Res. 2017 Dec;28(12):1567\u201376.","journal-title":"Clin Oral Implants Res."},{"issue":"6","key":"207_CR31","doi-asserted-by":"publisher","first-page":"e14","DOI":"10.1016\/j.tripleo.2006.05.001","volume":"102","author":"S Inal","year":"2006","unstructured":"Inal S, Yilmaz N, Nisbet C, G\u00fcven\u00e7 T. Biochemical and histopathological findings of N-butyl-2-cyanoacrylate in oral surgery: an experimental study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Dec;102(6):e14\u20137.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."}],"container-title":["International Journal of Implant Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40729-020-0207-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40729-020-0207-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40729-020-0207-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:44:49Z","timestamp":1666140289000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalimplantdent.springeropen.com\/articles\/10.1186\/s40729-020-0207-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,18]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["207"],"URL":"https:\/\/doi.org\/10.1186\/s40729-020-0207-1","relation":{},"ISSN":["2198-4034"],"issn-type":[{"value":"2198-4034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,18]]},"assertion":[{"value":"1 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The research protocol was submitted to and approved by the Ethical Committee of the University of Medical Sciences, School of Dentistry, Havana, Cuba (prot. 013\/2013).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All the authors consent to publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Alessandro Perini, Giada Ferrante, Stefano Sivolella, Joaqu\u00edn Urbizo Velez, Franco Bengazi, and Daniele Botticelli declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"11"}}