{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:30:21Z","timestamp":1791243021881,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the science and technology project of the state grid corporation of china","award":["52720016004N"],"award-info":[{"award-number":["52720016004N"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Implant Dent"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the clinical effects of concentrated growth factors (CGFs) combined with bone substitutes for alveolar ridge preservation (ARP) in the maxillary molar area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty-six patients who underwent extraction of the upper molars were recruited and randomly divided into three groups: 1. Grafted with CGFs combined with deproteinized bovine bone mineral (DBBM) and covered with CGFs membrane (CGFs\/DBBM group), 2. Grafted with DBBM alone and covered with collagen membrane (DBBM group), 3. Control group spontaneous healing. The area of the alveolar bone in center (C-), mesial (M-) and distal (D-) section was compared with preoperative in radiography. Bone cores were obtained for histopathology observation and comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In C-, M- and D-section, the alveolar ridge area in all three groups was significantly reduced at 8\u00a0months postoperatively compared to the baseline (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The alveolar ridge area declines in the CGFs\/DBBM group (C-12.75\u2009\u00b1\u20092.22\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      , M-14.69\u2009\u00b1\u20092.82\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      , D-16.95\u2009\u00b1\u20094.17\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      ) and DBBM group (C-14.08\u2009\u00b1\u20092.51\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      , M-15.42\u2009\u00b1\u20093.47\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      , D-16.09\u2009\u00b1\u20093.97\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      ) were non-significant differences. They were significantly less than the decline in the control group (C-45.04\u2009\u00b1\u20098.38\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      M-31.98\u2009\u00b1\u20098.34\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      , D-31.85\u2009\u00b1\u20098.52\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      ) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The percentage of newly formed bone in the CGFs\/DBBM group (41.99\u2009\u00b1\u200912.99%) was significantly greater than that in DBBM group (30.68\u2009\u00b1\u200910.95%) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The percentage of residual materials in the CGFs\/DBBM group (16.19\u2009\u00b1\u20096.63%) was significantly less than that in the DBBM group (28.35\u2009\u00b1\u200911.70%) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combined application of CGFs and DBBM effectively reduced the resorption of alveolar ridge and resulted in more newly formed bone than the use of DBBM with collagen membranes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40729-021-00396-x","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T07:02:49Z","timestamp":1638169369000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Clinical applications of concentrated growth factors combined with bone substitutes for alveolar ridge preservation in maxillary molar area: a randomized controlled trial"],"prefix":"10.1186","volume":"7","author":[{"given":"Shi-chen","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-yu","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"396_CR1","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/B978-0-08-102196-5.00011-2","volume":"2019","author":"MS Zafar","year":"2019","unstructured":"Zafar MS. 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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. All the recruited participants signed an informed consent form.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All data published here are under the consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"115"}}