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The impact of atorvastatin on bone regeneration in dental implantology in individuals with hyperlipidemia who received atorvastatin in the clinic is doubtful.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the study, 16 male New Zealand rabbits of 6 months were used. All rabbits were fed a high-cholesterol diet for 8 weeks, and hyperlipidemia was created. It was confirmed that the total cholesterol level in rabbits was above 105\u00a0mg\/dl. A critical-sized defect was created in the mandible. The defect was closed with xenograft and membrane. Oral 10\u00a0mg\/kg atorvastatin was started in the experimental group, and no drug was administered in the control group. At 16th week, animals were sacrificed. For histomorphological examination, the new bone area, osteoclast, and osteoblast activities were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      While new bone area (45,924 \u00b5m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and AP intensities (105.645\u2009\u00b1\u200916.727,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) were higher in the atorvastatin group than in the control group, TRAP intensities in the control group (82.192\u2009\u00b1\u20095.346,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021) were higher than that in the atorvastatin group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>It has been found that high blood lipid levels will adversely affect bone graft healing and the use of systemic atorvastatin contributes to bone healing. Clinicians should pay attention to the selection of surgical materials, considering the importance of questioning drug use in their patients and the risks in cases of non-use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40729-023-00508-9","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T12:02:21Z","timestamp":1702555341000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of systemic atorvastatin on bone regeneration in critical-sized defects in hyperlipidemia: an experimental study"],"prefix":"10.1186","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4447-0103","authenticated-orcid":false,"given":"K\u00fcbra","family":"\u00d6zt\u00fcrk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9478-1578","authenticated-orcid":false,"given":"Turan Emre","family":"Kuzu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1606-4151","authenticated-orcid":false,"given":"Semih","family":"Ayr\u0131k\u00e7il","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0811-008X","authenticated-orcid":false,"given":"Cem Abdulkadir","family":"G\u00fcrgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0515-9286","authenticated-orcid":false,"given":"G\u00f6zde \u00d6zge","family":"\u00d6nder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0541-8372","authenticated-orcid":false,"given":"Arzu","family":"Yay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"issue":"1","key":"508_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s40729-019-0170-x","volume":"5","author":"MB Tekin","year":"2019","unstructured":"Tekin MB, Toker H. 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