{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:24:51Z","timestamp":1793467491775,"version":"4.5.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012680","name":"Universit\u00e4tsklinikum Hamburg-Eppendorf","doi-asserted-by":"publisher","award":["Open Access Publication Fund of UKE - Universit\u00e4tsklinikum Hamburg-Eppendorf"],"award-info":[{"award-number":["Open Access Publication Fund of UKE - Universit\u00e4tsklinikum Hamburg-Eppendorf"]}],"id":[{"id":"10.13039\/501100012680","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012680","name":"Universit\u00e4tsklinikum Hamburg-Eppendorf","doi-asserted-by":"publisher","award":["DFG \u2013 German Research Foundation"],"award-info":[{"award-number":["DFG \u2013 German Research Foundation"]}],"id":[{"id":"10.13039\/501100012680","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Implant Dent"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Reconstruction with vascularized bone grafts after ablative surgery and subsequent dental rehabilitation with implants is often challenging; however, it helps improve the patient\u2019s quality of life. This retrospective case\u2013control study aimed to determine the implant survival\/success rates in different vascularized bone grafts and potential risk factors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Only patients who received implants in free vascularized bone grafts between 2012 and 2020 were included. The free flap donor sites were the fibula, iliac crest, and scapula. The prosthetic restoration had to be completed, and the observation period had to be over one year after implantation. Implant success was defined according to the Health Scale for Dental Implants criteria.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Sixty-two patients with 227 implants were included. The implant survival rate was 86.3% after an average of 48.7\u00a0months. The causes of implant loss were peri-implantitis (<jats:italic>n<\/jats:italic>\u2009=\u200924), insufficient osseointegration (<jats:italic>n<\/jats:italic>\u2009=\u20091), removal due to tumor recurrence (<jats:italic>n<\/jats:italic>\u2009=\u20091), and osteoradionecrosis (<jats:italic>n<\/jats:italic>\u2009=\u20095). Of all implants, 52.4% were classified as successful, 19.8% as compromised, and 27.8% as failed. Removal of osteosynthesis material prior to or concurrent with implant placement resulted in significantly better implant success than material not removed (<jats:italic>p<\/jats:italic>\u2009=\u20090.035). Localization of the graft in the mandibular region was associated with a significantly better implant survival (<jats:italic>p<\/jats:italic>\u2009=\u20090.034) and success (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), also a higher Karnofsky Performance Status Scale score with better implant survival (<jats:italic>p<\/jats:italic>\u2009=\u20090.014).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Implants placed in vascularized grafts showed acceptable survival rates despite the potential risk factors often present in these patient groups. However, peri-implantitis remains a challenge.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s40729-024-00522-5","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T13:02:28Z","timestamp":1707483748000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Outcomes and influencing factors of dental implants in fibula, iliac crest, and scapula free flaps: a retrospective case\u2013control study"],"prefix":"10.1186","volume":"10","author":[{"given":"Marina","family":"Kaiser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Burg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Speth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Luise","family":"Cotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Smeets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gosau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6291-1841","authenticated-orcid":false,"given":"Daniela","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"issue":"Suppl 1","key":"522_CR1","first-page":"E321","volume":"38","author":"S Ch'ng","year":"2016","unstructured":"Ch\u2019ng S, Skoracki RJ, Selber JC, Yu P, Martin JW, Hofstede TM, Chambers MS, Liu J, Hanasono MM. Osseointegrated implant-based dental rehabilitation in head and neck reconstruction patients. Head Neck. 2016;38(Suppl 1):E321\u20137.","journal-title":"Head Neck"},{"key":"522_CR2","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/j.1708-8208.2009.00250.x","volume":"14","author":"MR Fenlon","year":"2012","unstructured":"Fenlon MR, Lyons A, Farrell S, Bavisha K, Banerjee A, Palmer RM. Factors affecting survival and usefulness of implants placed in vascularized free composite grafts used in post-head and neck cancer reconstruction. Clin Implant Dent Relat Res. 2012;14:266\u201372. https:\/\/doi.org\/10.1111\/j.1708-8208.2009.00250.x.","journal-title":"Clin Implant Dent Relat Res"},{"key":"522_CR3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s40729-019-0161-y","volume":"5","author":"DP Laverty","year":"2019","unstructured":"Laverty DP, Addison O, Wubie BA, Heo G, Parmar S, Martin T, Praveen P, Pearson D, Newsum D, Murphy M, Bateman G. Outcomes of implant-based oral rehabilitation in head and neck oncology patients-a retrospective evaluation of a large, single regional service cohort. Int J Implant Dent. 2019;5:8.","journal-title":"Int J Implant Dent"},{"key":"522_CR4","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1016\/j.ijom.2013.05.007","volume":"42","author":"N Parbo","year":"2013","unstructured":"Parbo N, Murra NT, Andersen K, Buhl J, Kiil B, N\u00f8rholt SE. Outcome of partial mandibular reconstruction with fibula grafts and implant-supported prostheses. Int J Oral Maxillofac Surg. 2013;42:1403\u20138.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"522_CR5","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.11607\/jomi.3045","volume":"28","author":"N Nooh","year":"2013","unstructured":"Nooh N. Dental implant survival in irradiated oral cancer patients: a systematic review of the literature. Int J Oral Maxillofac Implants. 2013;28:1233\u201342.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"522_CR6","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.jcms.2017.01.014","volume":"45","author":"K Kniha","year":"2017","unstructured":"Kniha K, M\u00f6hlhenrich SC, Foldenauer AC, Peters F, Ayoub N, Goloborodko E, H\u00f6lzle F, Modabber A. Evaluation of bone resorption in fibula and deep circumflex iliac artery flaps following dental implantation: a three-year follow-up study. J Craniomaxillofac Surg. 2017;45:474\u20138.","journal-title":"J Craniomaxillofac Surg"},{"key":"522_CR7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40729-018-0131-9","volume":"4","author":"DP Laverty","year":"2018","unstructured":"Laverty DP, Kelly R, Addison O. Survival of dental implants placed in autogenous bone grafts and bone flaps in head and neck oncology patients: a systematic review. Int J Implant Dent. 2018;4:19.","journal-title":"Int J Implant Dent"},{"key":"522_CR8","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1097\/PRS.0000000000007077","volume":"146","author":"H Panchal","year":"2020","unstructured":"Panchal H, Shamsunder MG, Petrovic I, Rosen EB, Allen RJ, Hernandez M, Ganly I, Boyle JO, Matros E, Nelson JA. Dental implant survival in vascularized bone flaps: a systematic review and meta-analysis. Plast Reconstr Surg. 2020;146:637\u201348. https:\/\/doi.org\/10.1097\/PRS.0000000000007077.","journal-title":"Plast Reconstr Surg"},{"key":"522_CR9","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1111\/cid.12658","volume":"20","author":"G Pellegrino","year":"2018","unstructured":"Pellegrino G, Tarsitano A, Ferri A, Corinaldesi G, Bianchi A, Marchetti C. Long-term results of osseointegrated implant-based dental rehabilitation in oncology patients reconstructed with a fibula free flap. Clin Implant Dent Relat Res. 2018;20:852\u20139.","journal-title":"Clin Implant Dent Relat Res"},{"key":"522_CR10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s40729-022-00413-7","volume":"8","author":"H Ma","year":"2022","unstructured":"Ma H, van Dessel J, Shujaat S, Bila M, Sun Y, Politis C, Jacobs R. Long-term survival of implant-based oral rehabilitation following maxillofacial reconstruction with vascularized bone flap. Int J Implant Dent. 2022;8:15. https:\/\/doi.org\/10.1186\/s40729-022-00413-7.","journal-title":"Int J Implant Dent"},{"key":"522_CR11","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jdent.2019.03.008","volume":"84","author":"M-S Howe","year":"2019","unstructured":"Howe M-S, Keys W, Richards D. Long-term (10-year) dental implant survival: a systematic review and sensitivity meta-analysis. J Dent. 2019;84:9\u201321.","journal-title":"J Dent"},{"key":"522_CR12","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1002\/hed.24609","volume":"39","author":"M Burgess","year":"2017","unstructured":"Burgess M, Leung M, Chellapah A, Clark JR, Batstone MD. Osseointegrated implants into a variety of composite free flaps: a comparative analysis. Head Neck. 2017;39:443\u20137.","journal-title":"Head Neck"},{"key":"522_CR13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40729-022-00409-3","volume":"8","author":"T Watanabe","year":"2022","unstructured":"Watanabe T, Kawahara D, Inoue R, Kato T, Ishihara N, Kamiya H, Bessho K. Squamous cell carcinoma around a subperiosteal implant in the maxilla and the association of chronic mechanical irritation and peri-implantitis: a case report. Int J Implant Dent. 2022;8:10.","journal-title":"Int J Implant Dent"},{"issue":"Suppl 1","key":"522_CR14","first-page":"S267","volume":"89","author":"F Schwarz","year":"2018","unstructured":"Schwarz F, Derks J, Monje A, Wang H-L. Peri-implantitis. J Periodontol. 2018;89(Suppl 1):S267\u201390.","journal-title":"J Periodontol"},{"key":"522_CR15","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.jcms.2018.05.008","volume":"46","author":"S Attia","year":"2018","unstructured":"Attia S, Wiltfang J, Pons-K\u00fchnemann J, Wilbrand J-F, Streckbein P, K\u00e4hling C, Howaldt H-P, Schaaf H. Survival of dental implants placed in vascularised fibula free flaps after jaw reconstruction. J Craniomaxillofac Surg. 2018;46:1205\u201310.","journal-title":"J Craniomaxillofac Surg"},{"key":"522_CR16","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1002\/jbm.b.33042","volume":"102","author":"C Brito","year":"2014","unstructured":"Brito C, Tenenbaum HC, Wong BKC, Schmitt C, Nogueira-Filho G. Is keratinized mucosa indispensable to maintain peri-implant health? A systematic review of the literature. J Biomed Mater Res B Appl Biomater. 2014;102:643\u201350.","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"522_CR17","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.ijom.2018.01.012","volume":"47","author":"MM Curi","year":"2018","unstructured":"Curi MM, Condezo AFB, Ribeiro KDCB, Cardoso CL. Long-term success of dental implants in patients with head and neck cancer after radiation therapy. Int J Oral Maxillofac Surg. 2018;47:783\u20138.","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"Suppl 6","key":"522_CR18","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1600-0501.2012.02541.x","volume":"23","author":"A Mombelli","year":"2012","unstructured":"Mombelli A, M\u00fcller N, Cionca N. The epidemiology of peri-implantitis. Clin Oral Implants Res. 2012;23(Suppl 6):67\u201376.","journal-title":"Clin Oral Implants Res"},{"key":"522_CR19","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.jdent.2015.03.003","volume":"43","author":"BR Chrcanovic","year":"2015","unstructured":"Chrcanovic BR, Albrektsson T, Wennerberg A. Smoking and dental implants: a systematic review and meta-analysis. J Dent. 2015;43:487\u201398.","journal-title":"J Dent"},{"key":"522_CR20","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1177\/0022034516646098","volume":"95","author":"BR Chrcanovic","year":"2016","unstructured":"Chrcanovic BR, Kisch J, Albrektsson T, Wennerberg A. Factors influencing early dental implant failures. J Dent Res. 2016;95:995\u20131002.","journal-title":"J Dent Res"},{"key":"522_CR21","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s40729-021-00372-5","volume":"7","author":"G Khaleghi","year":"2021","unstructured":"Khaleghi G, Mahdavi H, Mahdavi SR, Khajetash B, Nikoofar A, Hosntalab M, Sadeghi M, Reiazi R. Investigating dose homogeneity in radiotherapy of oral cancers in the presence of a dental implant system: an in vitro phantom study. Int J Implant Dent. 2021;7:90.","journal-title":"Int J Implant Dent"},{"key":"522_CR22","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1097\/ID.0b013e3181676059","volume":"17","author":"CE Misch","year":"2008","unstructured":"Misch CE, Perel ML, Wang H-L, Sammartino G, Galindo-Moreno P, Trisi P, Steigmann M, Rebaudi A, Palti A, Pikos MA, Schwartz-Arad D, Choukroun J, Gutierrez-Perez J-L, Marenzi G, Valavanis DK. Implant success, survival, and failure: the International Congress of Oral Implantologists (ICOI) Pisa Consensus Conference. Implant Dent. 2008;17:5\u201315.","journal-title":"Implant Dent"},{"key":"522_CR23","volume-title":"TNM classification of malignant tumours","author":"JD Brierley","year":"2017","unstructured":"Brierley JD. TNM classification of malignant tumours. 8th ed. Chichester: Wiley Blackwell; 2017.","edition":"8"},{"key":"522_CR24","first-page":"45","volume":"7","author":"CM Bruggenkate ten","year":"1990","unstructured":"Bruggenkate ten CM, van der Kwast WA, Oosterbeek HS. Success criteria in oral implantology. A review of the literature. Int J Oral Implantol. 1990;7:45\u201351.","journal-title":"Int J Oral Implantol"},{"key":"522_CR25","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1111\/clr.13822","volume":"32","author":"D Khadembaschi","year":"2021","unstructured":"Khadembaschi D, Russell P, Beech N, Batstone MD. Osseointegrated implant survival, success and prosthodontic outcomes in composite free flaps: a 10-year retrospective cohort study. Clin Oral Implants Res. 2021;32:1251\u201361.","journal-title":"Clin Oral Implants Res"},{"key":"522_CR26","first-page":"11","volume":"1","author":"T Albrektsson","year":"1986","unstructured":"Albrektsson T, Zarb G, Worthington P, Eriksson AR. The long-term efficacy of currently used dental implants: a review and proposed criteria of success. Int J Oral Maxillofac Implants. 1986;1:11\u201325.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"522_CR27","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/j.1600-0501.2005.01212.x","volume":"17","author":"M Chiapasco","year":"2006","unstructured":"Chiapasco M, Biglioli F, Autelitano L, Romeo E, Brusati R. Clinical outcome of dental implants placed in fibula-free flaps used for the reconstruction of maxillo-mandibular defects following ablation for tumors or osteoradionecrosis. Clin Oral Implants Res. 2006;17:220\u20138.","journal-title":"Clin Oral Implants Res"},{"key":"522_CR28","doi-asserted-by":"publisher","DOI":"10.5037\/jomr.2022.13103","volume":"13","author":"P Gangwani","year":"2022","unstructured":"Gangwani P, Almana M, Barmak B, Kolokythas A. What is the success of implants placed in fibula flap? A systematic review and meta-analysis. J Oral Maxillofac Res. 2022;13: e3.","journal-title":"J Oral Maxillofac Res"},{"key":"522_CR29","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.jcms.2021.03.002","volume":"49","author":"JN Lodders","year":"2021","unstructured":"Lodders JN, Leusink FKJ, Ridwan-Pramana A, Winters HAH, Karagozoglu KH, Dekker H, Forouzanfar T, Schulten EAJM. Long-term outcomes of implant-based dental rehabilitation in head and neck cancer patients after reconstruction with the free vascularized fibula flap. J Craniomaxillofac Surg. 2021;49:845\u201354.","journal-title":"J Craniomaxillofac Surg"},{"key":"522_CR30","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1600-0501.2010.01999.x","volume":"22","author":"M Chiapasco","year":"2011","unstructured":"Chiapasco M, Romeo E, Coggiola A, Brusati R. Long-term outcome of dental implants placed in revascularized fibula free flaps used for the reconstruction of maxillo-mandibular defects due to extreme atrophy. Clin Oral Implants Res. 2011;22:83\u201391.","journal-title":"Clin Oral Implants Res"},{"key":"522_CR31","doi-asserted-by":"publisher","first-page":"169","DOI":"10.11607\/jomi.3606","volume":"30","author":"W Fang","year":"2015","unstructured":"Fang W, Liu Y-P, Ma Q, Liu B-L, Zhao Y. Long-term results of mandibular reconstruction of continuity defects with fibula free flap and implant-borne dental rehabilitation. Int J Oral Maxillofac Implants. 2015;30:169\u201378.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"522_CR32","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1177\/0022034511431252","volume":"91","author":"P Papaspyridakos","year":"2012","unstructured":"Papaspyridakos P, Chen C-J, Singh M, Weber H-P, Gallucci GO. Success criteria in implant dentistry: a systematic review. J Dent Res. 2012;91:242\u20138.","journal-title":"J Dent Res"},{"key":"522_CR33","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1002\/1097-0142(194811)1:4<634::AID-CNCR2820010410>3.0.CO;2-L","volume":"1","author":"DA Karnofsky","year":"1948","unstructured":"Karnofsky DA, Abelmann WH, Craver LF, Burchenal JH. The use of the nitrogen mustards in the palliative treatment of carcinoma. With particular reference to bronchogenic carcinoma. Cancer. 1948;1:634\u201356.","journal-title":"Cancer"},{"key":"522_CR34","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1177\/1457496918772365","volume":"108","author":"T Wilkman","year":"2019","unstructured":"Wilkman T, Husso A, Lassus P. Clinical comparison of scapular, fibular, and iliac crest osseal free flaps in maxillofacial reconstructions. Scand J Surg. 2019;108:76\u201382.","journal-title":"Scand J Surg"},{"key":"522_CR35","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1016\/j.jcms.2016.09.011","volume":"44","author":"SC M\u00f6hlhenrich","year":"2016","unstructured":"M\u00f6hlhenrich SC, Kniha K, Elvers D, Ayoub N, Goloborodko E, H\u00f6lzle F, Modabber A. Intraosseous stability of dental implants in free revascularized fibula and iliac crest bone flaps. J Craniomaxillofac Surg. 2016;44:1935\u20139.","journal-title":"J Craniomaxillofac Surg"},{"key":"522_CR36","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.joms.2005.12.073","volume":"65","author":"M Akkocaoglu","year":"2007","unstructured":"Akkocaoglu M, Cehreli MC, Tekdemir I, Comert A, G\u00fczel E, Da\u011fdeviren A, Akca K. Primary stability of simultaneously placed dental implants in extraoral donor graft sites: a human cadaver study. J Oral Maxillofac Surgery. 2007;65:400\u20137.","journal-title":"J Oral Maxillofac Surgery"},{"key":"522_CR37","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/S0022-3913(96)90435-7","volume":"76","author":"R Haas","year":"1996","unstructured":"Haas R, Haimb\u00f6ck W, Mailath G, Watzek G. The relationship of smoking on peri-implant tissue: a retrospective study. J Prosthet Dent. 1996;76:592\u20136.","journal-title":"J Prosthet Dent"},{"key":"522_CR38","doi-asserted-by":"publisher","first-page":"38","DOI":"10.4103\/2231-0762.109358","volume":"2","author":"V Kasat","year":"2012","unstructured":"Kasat V, Ladda R. Smoking and dental implants. J Int Soc Prev Community Dent. 2012;2:38\u201341.","journal-title":"J Int Soc Prev Community Dent"},{"key":"522_CR39","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.546","volume":"2","author":"D Twito","year":"2014","unstructured":"Twito D, Sade P. The effect of cigarette smoking habits on the outcome of dental implant treatment. PeerJ. 2014;2: e546.","journal-title":"PeerJ"},{"key":"522_CR40","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1111\/jcpe.13257","volume":"47","author":"R Naseri","year":"2020","unstructured":"Naseri R, Yaghini J, Feizi A. Levels of smoking and dental implants failure: a systematic review and meta-analysis. J Clin Periodontol. 2020;47:518\u201328.","journal-title":"J Clin Periodontol"},{"key":"522_CR41","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/jopr.12508","volume":"27","author":"J Neves","year":"2018","unstructured":"Neves J, Ara\u00fajo Nobre de M, Oliveira P, Martins Dos Santos J, Malo P. Risk factors for implant failure and peri-implant pathology in systemic compromised patients. J prosthodont. 2018;27:409\u201315.","journal-title":"J prosthodont"},{"key":"522_CR42","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1001\/jamafacial.2015.2271","volume":"18","author":"RS Jackson","year":"2016","unstructured":"Jackson RS, Price DL, Arce K, Moore EJ. Evaluation of clinical outcomes of osseointegrated dental implantation of fibula free flaps for mandibular reconstruction. JAMA Facial Plast Surg. 2016;18:201\u20136.","journal-title":"JAMA Facial Plast Surg"},{"key":"522_CR43","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s40729-021-00373-4","volume":"7","author":"E Schiegnitz","year":"2021","unstructured":"Schiegnitz E, M\u00fcller LK, Sagheb K, Theis L, Cagiran V, K\u00e4mmerer PW, Wegener J, Wagner W, Al-Nawas B. Clinical long-term and patient-reported outcomes of dental implants in oral cancer patients. Int J Implant Dent. 2021;7:93.","journal-title":"Int J Implant Dent"},{"key":"522_CR44","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1002\/hed.23875","volume":"38","author":"BR Chrcanovic","year":"2016","unstructured":"Chrcanovic BR, Albrektsson T, Wennerberg A. Dental implants in irradiated versus nonirradiated patients: a meta-analysis. Head Neck. 2016;38:448\u201381.","journal-title":"Head Neck"},{"key":"522_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071955","volume":"8","author":"H Chen","year":"2013","unstructured":"Chen H, Liu N, Xu X, Qu X, Lu E. Smoking, radiotherapy, diabetes and osteoporosis as risk factors for dental implant failure: a meta-analysis. PLoS ONE. 2013;8: e71955.","journal-title":"PLoS ONE"},{"issue":"Suppl 1","key":"522_CR46","first-page":"E2229","volume":"38","author":"EV ZenFilho","year":"2016","unstructured":"ZenFilho EV, Tolentino EDS, Santos PSS. Viability of dental implants in head and neck irradiated patients: a systematic review. Head Neck. 2016;38(Suppl 1):E2229\u201340.","journal-title":"Head Neck"},{"key":"522_CR47","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/cid.12096","volume":"17","author":"MP Claudy","year":"2015","unstructured":"Claudy MP, Miguens SAQ, Celeste RK, Camara Parente R, Hernandez PAG, da Silva AN. Time interval after radiotherapy and dental implant failure: systematic review of observational studies and meta-analysis. Clin Implant Dent Relat Res. 2015;17:402\u201311.","journal-title":"Clin Implant Dent Relat Res"},{"issue":"6","key":"522_CR48","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1097\/00006534-198512000-00006","volume":"76","author":"MG Jacobsson","year":"1985","unstructured":"Jacobsson MG, et al. Short- and long-term effects of irradiation on bone regeneration. Plast Reconstr Surg. 1985;76(6):848\u2013841.","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"522_CR49","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/0030-4220(87)90136-8","volume":"64","author":"RE Marx","year":"1987","unstructured":"Marx RE, Johnson RP. Studies in the radiobiology of osteoradionecrosis and their clinical significance. Oral Surg Oral Med Oral Pathol. 1987;64(4):379\u201390.","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"522_CR50","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.oraloncology.2003.08.024","volume":"40","author":"PJ Schoen","year":"2004","unstructured":"Schoen PJ, Reintsema H, Raghoebar GM, Vissink A, Roodenburg JLN. The use of implant retained mandibular prostheses in the oral rehabilitation of head and neck cancer patients. A review and rationale for treatment planning. Oral Oncol. 2004;40:862\u201371. https:\/\/doi.org\/10.1016\/j.oraloncology.2003.08.024.","journal-title":"Oral Oncol"},{"key":"522_CR51","doi-asserted-by":"publisher","first-page":"3290","DOI":"10.1002\/hed.25845","volume":"41","author":"P Moore","year":"2019","unstructured":"Moore P, Grinsell D, Lyons B, Hewson I. Outcomes of dental and craniofacial osseointegrated implantation in head and neck cancer patients. Head Neck. 2019;41:3290\u20138.","journal-title":"Head Neck"},{"key":"522_CR52","doi-asserted-by":"publisher","first-page":"e134","DOI":"10.1097\/SCS.0000000000006874","volume":"32","author":"E Zavattero","year":"2021","unstructured":"Zavattero E, Ramieri G, Agr\u00f2 G, Fasolis M, Garzino-Demo P, Borbon C. Implant dental rehabilitation of fibula-free flap reconstructed jaws. J Craniofac Surg. 2021;32:e134\u20136.","journal-title":"J Craniofac Surg"},{"key":"522_CR53","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1111\/odi.13451","volume":"26","author":"F Goker","year":"2020","unstructured":"Goker F, Baj A, Bolzoni AR, Maiorana C, Racco P, Taschieri S, Beretta P, Beltramini G, Gianni AB, Del Fabbro M. Effectiveness of dental implants placed into microvascular free flaps. Oral Dis. 2020;26:1532\u20136.","journal-title":"Oral Dis"},{"key":"522_CR54","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1097\/00000637-198912000-00005","volume":"23","author":"DA Hidalgo","year":"1989","unstructured":"Hidalgo DA. Titanium miniplate fixation in free flap mandible reconstruction. Ann Plast Surg. 1989;23:498\u2013507.","journal-title":"Ann Plast Surg"},{"key":"522_CR55","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1097\/00006534-200003000-00025","volume":"105","author":"AA Chiodo","year":"2000","unstructured":"Chiodo AA, Gur E, Pang CY, Neligan PC, Boyd JB, Binhammer PM, Forrest CR. The vascularized pig fibula bone flap model: effect of segmental osteotomies and internal fixation on blood flow. Plast Reconstr Surg. 2000;105:1004\u201312.","journal-title":"Plast Reconstr Surg"},{"key":"522_CR56","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1097\/00006534-198907000-00014","volume":"84","author":"DA Hidalgo","year":"1989","unstructured":"Hidalgo DA. Fibula free flap: a new method of mandible reconstruction. Plast Reconstr Surg. 1989;84:71\u20139.","journal-title":"Plast Reconstr Surg"},{"key":"522_CR57","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1097\/00003086-197411000-00005","volume":"105","author":"FW Rhinelander","year":"1974","unstructured":"Rhinelander FW. Tibial blood supply in relation to fracture healing. Clin Orthop Relat Res. 1974;105:34\u201381.","journal-title":"Clin Orthop Relat Res"},{"key":"522_CR58","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1097\/00005131-199710000-00006","volume":"11","author":"R Jain","year":"1997","unstructured":"Jain R, Podworny N, Hearn T, Anderson GI, Schemitsch EH. Effect of stainless steel and titanium low-contact dynamic compression plate application on the vascularity and mechanical properties of cortical bone after fracture. J Orthop Trauma. 1997;11:490\u20135.","journal-title":"J Orthop Trauma"},{"key":"522_CR59","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1002\/jor.1100130511","volume":"13","author":"PJ Kregor","year":"1995","unstructured":"Kregor PJ, Senft D, Parvin D, Campbell C, Toomey S, Parker C, Gillespy T, Swiontkowski MF. Cortical bone perfusion in plated fractured sheep tibiae. J Orthop Res. 1995;13:715\u201324.","journal-title":"J Orthop Res"},{"key":"522_CR60","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1302\/0301-620X.65B1.6822605","volume":"65","author":"HK Uhthoff","year":"1983","unstructured":"Uhthoff HK, Finnegan M. The effects of metal plates on post-traumatic remodelling and bone mass. J Bone Joint Surg Br. 1983;65:66\u201371.","journal-title":"J Bone Joint Surg Br"}],"container-title":["International Journal of Implant Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40729-024-00522-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40729-024-00522-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40729-024-00522-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T14:05:48Z","timestamp":1707487548000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalimplantdent.springeropen.com\/articles\/10.1186\/s40729-024-00522-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,9]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["522"],"URL":"https:\/\/doi.org\/10.1186\/s40729-024-00522-5","relation":{},"ISSN":["2198-4034"],"issn-type":[{"value":"2198-4034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,9]]},"assertion":[{"value":"22 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"After inquiry with the local ethics committee (Ethik-Kommission der \u00c4rztekammer Hamburg), no ethics vote is required due to the anonymized use of patient data. All methods were carried out following relevant guidelines and regulations according to the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8"}}