{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:50:43Z","timestamp":1761709843783,"version":"3.37.3"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T00:00:00Z","timestamp":1616803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T00:00:00Z","timestamp":1616803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1120689","#550905"],"award-info":[{"award-number":["APP1120689","#550905"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Fertil Res and Pract"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Abnormalities in endometrial receptivity has been identified as a major barrier to successful embryo implantation. Endometrial receptivity refers to the conformational and biochemical changes occurring in the endometrial epithelial layer which make it adhesive and receptive to blastocyst attachment. This takes place during the mid-secretory phase of woman\u2019s menstrual cycle and is a result of a delicate interplay between numerous hormones, cytokines and other factors. Outside of this window, the endometrium is refractory to an implanting blastocyst. It has been shown that Notch ligands and receptors are dysregulated in the endometrium of infertile women. Mastermind Like Transcriptional Coactivator 1 (MAML1) is a known coactivator of the Notch signaling pathway. This study aimed to determine the role of MAML1 in regulating endometrial receptivity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The expression and localization of MAML1 in the fertile human endometrium (non-receptive proliferative phase versus receptive mid-secretory phase) were determined by immunohistochemistry. Ishikawa cells were used as an endometrial epithelial model to investigate the functional consequences of <jats:italic>MAML1<\/jats:italic> knockdown on endometrial adhesive capacity to HTR8\/SVneo (trophoblast cell line) spheroids. After <jats:italic>MAML1<\/jats:italic> knockdown in Ishikawa cells, the expression of endometrial receptivity markers and Notch dependent and independent pathway members were assessed by qPCR. Two-tailed unpaired or paired student\u2019s t-test were used for statistical analysis with a significance threshold of <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>MAML1 was localized in the luminal epithelium, glandular epithelium and stroma of human endometrium and the increased expression identified in the mid-secretory phase was restricted only to the luminal epithelium (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Functional analysis using Ishikawa cells demonstrated that knockdown of <jats:italic>MAML1<\/jats:italic> significantly reduced epithelial adhesive capacity (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) to HTR8\/SVneo (trophoblast cell line) spheroids compared to control. <jats:italic>MAML1<\/jats:italic> knockdown significantly affected the expression of classical receptivity markers (<jats:italic>SPP1<\/jats:italic>, <jats:italic>DPP4<\/jats:italic>) and this response was not directly via hormone receptors. The expression level of Hippo pathway target Ankyrin repeat domain-containing protein 1 (<jats:italic>ANKRD1)<\/jats:italic> was also affected after <jats:italic>MAML1<\/jats:italic> knockdown in Ishikawa cells.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our data strongly suggest that MAML1 is involved in regulating the endometrial adhesive capacity and may facilitate embryo attachment, either directly or indirectly through the Notch signaling pathway.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40738-021-00100-y","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T06:02:38Z","timestamp":1616824958000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["MAML1: a coregulator that alters endometrial epithelial cell adhesive capacity"],"prefix":"10.1186","volume":"7","author":[{"given":"Sadaf","family":"Zafir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Menkhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leilani","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evdokia","family":"Dimitriadis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,27]]},"reference":[{"issue":"2","key":"100_CR1","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1093\/humupd\/dmy044","volume":"25","author":"L Craciunas","year":"2019","unstructured":"Craciunas L, Gallos I, Chu J, Bourne T, Quenby S, Brosens JJ, et al. Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis. Hum Reprod Update. 2019;25(2):202\u201323. https:\/\/doi.org\/10.1093\/humupd\/dmy044.","journal-title":"Hum Reprod Update"},{"issue":"4","key":"100_CR2","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1056\/NEJM198807283190401","volume":"319","author":"AJ Wilcox","year":"1988","unstructured":"Wilcox AJ, Weinberg CR, O'Connor JF, Baird DD, Schlatterer JP, Canfield RE, et al. Incidence of early loss of pregnancy. N Engl J Med. 1988;319(4):189\u201394. https:\/\/doi.org\/10.1056\/NEJM198807283190401.","journal-title":"N Engl J Med"},{"issue":"6","key":"100_CR3","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1055\/s-0042-103752","volume":"76","author":"N Katzorke","year":"2016","unstructured":"Katzorke N, Vilella F, Ruiz M, Kr\u00fcssel J-S, Simon C. Diagnosis of endometrial-factor infertility: current approaches and new avenues for research. Geburtshilfe Frauenheilkd. 2016;76(6):699\u2013703. https:\/\/doi.org\/10.1055\/s-0042-103752.","journal-title":"Geburtshilfe Frauenheilkd"},{"issue":"4","key":"100_CR4","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.fertnstert.2019.02.009","volume":"111","author":"BA Lessey","year":"2019","unstructured":"Lessey BA, Young SL. What exactly is endometrial receptivity? Fertil Steril. 2019;111(4):611\u20137. https:\/\/doi.org\/10.1016\/j.fertnstert.2019.02.009.","journal-title":"Fertil Steril"},{"issue":"11","key":"100_CR5","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/nrendo.2016.116","volume":"12","author":"J Evans","year":"2016","unstructured":"Evans J, Salamonsen LA, Winship A, Menkhorst E, Nie G, Gargett CE, et al. Fertile ground: human endometrial programming and lessons in health and disease. Nat Rev Endocrinol. 2016;12(11):654\u201367. https:\/\/doi.org\/10.1038\/nrendo.2016.116.","journal-title":"Nat Rev Endocrinol"},{"issue":"6","key":"100_CR6","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.3390\/ijms21061973","volume":"21","author":"MA Ochoa-Bernal","year":"2020","unstructured":"Ochoa-Bernal MA, Fazleabas AT. Physiologic events of embryo implantation and Decidualization in human and non-human primates. Int J Mol Sci. 2020;21(6):1973. https:\/\/doi.org\/10.3390\/ijms21061973.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"100_CR7","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1007\/s10735-014-9587-y","volume":"45","author":"M Van Sinderen","year":"2014","unstructured":"Van Sinderen M, Cuman C, Gamage T, Rainczuk K, Osianlis T, Rombauts L, et al. Localisation of the notch family in the human endometrium of fertile and infertile women. J Mol Histol. 2014;45(6):697\u2013706. https:\/\/doi.org\/10.1007\/s10735-014-9587-y.","journal-title":"J Mol Histol"},{"issue":"11","key":"100_CR8","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/nrm.2016.94","volume":"17","author":"SJ Bray","year":"2016","unstructured":"Bray SJ. Notch signalling in context. Nat Rev Mol Cell Biol. 2016;17(11):722\u201335.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"100_CR9","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1111\/j.1469-7580.2008.00963.x","volume":"213","author":"L Cobellis","year":"2008","unstructured":"Cobellis L, Caprio F, Trabucco E, Mastrogiacomo A, Coppola G, Manente L, et al. The pattern of expression of notch protein members in normal and pathological endometrium. J Anat. 2008;213(4):464\u201372. https:\/\/doi.org\/10.1111\/j.1469-7580.2008.00963.x.","journal-title":"J Anat"},{"issue":"3","key":"100_CR10","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.bbrc.2009.07.037","volume":"388","author":"A Mikhailik","year":"2009","unstructured":"Mikhailik A, Mazella J, Liang S, Tseng L. Notch ligand-dependent gene expression in human endometrial stromal cells. Biochem Biophys Res Commun. 2009;388(3):479\u201382. https:\/\/doi.org\/10.1016\/j.bbrc.2009.07.037.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"100_CR11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1210\/en.2007-0477","volume":"149","author":"J Mazella","year":"2008","unstructured":"Mazella J, Liang S, Tseng L. Expression of Delta-like protein 4 in the human endometrium. Endocrinology. 2008;149(1):15\u20139. https:\/\/doi.org\/10.1210\/en.2007-0477.","journal-title":"Endocrinology"},{"issue":"3","key":"100_CR12","doi-asserted-by":"publisher","first-page":"R75","DOI":"10.1530\/REP-13-0474","volume":"147","author":"C Cuman","year":"2014","unstructured":"Cuman C, Menkhorst E, Winship A, Van Sinderen M, Osianlis T, Rombauts LJ, et al. Fetal-maternal communication: the role of notch signalling in embryo implantation. Reproduction. 2014;147(3):R75\u201386. https:\/\/doi.org\/10.1530\/REP-13-0474.","journal-title":"Reproduction"},{"issue":"3","key":"100_CR13","doi-asserted-by":"publisher","first-page":"E433","DOI":"10.1210\/jc.2014-3720","volume":"100","author":"R-W Su","year":"2015","unstructured":"Su R-W, Strug MR, Joshi NR, Jeong J-W, Miele L, Lessey BA, et al. Decreased notch pathway signaling in the endometrium of women with endometriosis impairs decidualization. J Clin Endocrinol Metab. 2015;100(3):E433\u201342. https:\/\/doi.org\/10.1210\/jc.2014-3720.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"100_CR14","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1096\/fj.11-184663","volume":"26","author":"Y Afshar","year":"2012","unstructured":"Afshar Y, Jeong J-W, Roqueiro D, DeMayo F, Lydon J, Radtke F, et al. Notch1 mediates uterine stromal differentiation and is critical for complete decidualization in the mouse. FASEB J. 2012;26(1):282\u201394. https:\/\/doi.org\/10.1096\/fj.11-184663.","journal-title":"FASEB J"},{"issue":"23","key":"100_CR15","doi-asserted-by":"publisher","first-page":"4449","DOI":"10.1242\/dev.084871","volume":"139","author":"JJ Hofmann","year":"2012","unstructured":"Hofmann JJ, Briot A, Enciso J, Zovein AC, Ren S, Zhang ZW, et al. Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development. 2012;139(23):4449\u201360. https:\/\/doi.org\/10.1242\/dev.084871.","journal-title":"Development"},{"key":"100_CR16","doi-asserted-by":"publisher","first-page":"596324","DOI":"10.3389\/fendo.2020.596324","volume":"11","author":"S Whitby","year":"2020","unstructured":"Whitby S, Zhou W, Dimitriadis E. Alterations in epithelial cell polarity during endometrial receptivity: a systematic review. Front Endocrinol. 2020;11:596324. https:\/\/doi.org\/10.3389\/fendo.2020.596324.","journal-title":"Front Endocrinol"},{"issue":"4","key":"100_CR17","doi-asserted-by":"publisher","first-page":"426","DOI":"10.22038\/ijbms.2019.32961.7874","volume":"22","author":"F Amjadi","year":"2019","unstructured":"Amjadi F, Salehi E, Zandieh Z, Rashidi M, Taleahmad S. Comparative evaluation of NOTCH signaling molecules in the endometrium of women with various gynecological diseases during the window of implantation. Iran J Basic Med Sci. 2019;22(4):426\u201331. https:\/\/doi.org\/10.22038\/ijbms.2019.32961.7874.","journal-title":"Iran J Basic Med Sci"},{"issue":"5","key":"100_CR18","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1093\/humrep\/det058","volume":"28","author":"C Cuman","year":"2013","unstructured":"Cuman C, Menkhorst E, Rombauts L, Holden S, Webster D, Bilandzic M, et al. Preimplantation human blastocysts release factors that differentially alter human endometrial epithelial cell adhesion and gene expression relative to IVF success. Hum Reprod. 2013;28(5):1161\u201371. https:\/\/doi.org\/10.1093\/humrep\/det058.","journal-title":"Hum Reprod"},{"issue":"23","key":"100_CR19","doi-asserted-by":"publisher","first-page":"21232","DOI":"10.1074\/jbc.M301567200","volume":"278","author":"Y Nam","year":"2003","unstructured":"Nam Y, Weng AP, Aster JC, Blacklow SC. Structural requirements for assembly of the CSL\u00b7 intracellular Notch1\u00b7 mastermind-like 1 transcriptional activation complex. J Biol Chem. 2003;278(23):21232\u20139. https:\/\/doi.org\/10.1074\/jbc.M301567200.","journal-title":"J Biol Chem"},{"issue":"23","key":"100_CR20","doi-asserted-by":"publisher","first-page":"5235","DOI":"10.1242\/dev.062802","volume":"138","author":"T Oyama","year":"2011","unstructured":"Oyama T, Harigaya K, Sasaki N, Okamura Y, Kokubo H, Saga Y, et al. Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for notch signaling in vivo. Development. 2011;138(23):5235\u201346. https:\/\/doi.org\/10.1242\/dev.062802.","journal-title":"Development"},{"issue":"21","key":"100_CR21","doi-asserted-by":"publisher","first-page":"7688","DOI":"10.1128\/MCB.22.21.7688-7700.2002","volume":"22","author":"L Wu","year":"2002","unstructured":"Wu L, Sun T, Kobayashi K, Gao P, Griffin JD. Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Mol Cell Biol. 2002;22(21):7688\u2013700. https:\/\/doi.org\/10.1128\/MCB.22.21.7688-7700.2002.","journal-title":"Mol Cell Biol"},{"issue":"1","key":"100_CR22","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1146\/annurev-biochem-013118-111829","volume":"88","author":"S Ma","year":"2019","unstructured":"Ma S, Meng Z, Chen R, Guan K-L. The hippo pathway: biology and pathophysiology. Annu Rev Biochem. 2019;88(1):577\u2013604. https:\/\/doi.org\/10.1146\/annurev-biochem-013118-111829.","journal-title":"Annu Rev Biochem"},{"key":"100_CR23","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.placenta.2017.03.013","volume":"53","author":"H Chen","year":"2017","unstructured":"Chen H, Song Y, Yang S, Fu J, Feng X, Huang W. YAP mediates human decidualization of the uterine endometrial stromal cells. Placenta. 2017;53:30\u20135. https:\/\/doi.org\/10.1016\/j.placenta.2017.03.013.","journal-title":"Placenta"},{"issue":"22","key":"100_CR24","doi-asserted-by":"publisher","first-page":"2732","DOI":"10.4103\/0366-6999.218013","volume":"130","author":"H-Y Zhu","year":"2017","unstructured":"Zhu H-Y, Ge T-X, Pan Y-B, Zhang S-Y. Advanced role of hippo signaling in endometrial fibrosis: implications for intrauterine adhesion. Chin Med J. 2017;130(22):2732\u20137. https:\/\/doi.org\/10.4103\/0366-6999.218013.","journal-title":"Chin Med J"},{"issue":"24","key":"100_CR25","doi-asserted-by":"publisher","first-page":"13529","DOI":"10.1073\/pnas.1917969117","volume":"117","author":"J Kim","year":"2020","unstructured":"Kim J, Kwon H, Shin YK, Song G, Lee T, Kim Y, et al. MAML1\/2 promote YAP\/TAZ nuclear localization and tumorigenesis. Proc Natl Acad Sci U S A. 2020;117(24):13529\u201340. https:\/\/doi.org\/10.1073\/pnas.1917969117.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"19","key":"100_CR26","doi-asserted-by":"publisher","first-page":"14356","DOI":"10.1074\/jbc.M109.078865","volume":"285","author":"B Jin","year":"2010","unstructured":"Jin B, Shen H, Lin S, Li J-L, Chen Z, Griffin JD, et al. The mastermind-like 1 (MAML1) co-activator regulates constitutive NF-\u03baB signaling and cell survival. J Biol Chem. 2010;285(19):14356\u201365. https:\/\/doi.org\/10.1074\/jbc.M109.078865.","journal-title":"J Biol Chem"},{"issue":"2","key":"100_CR27","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1096\/fj.10-160291","volume":"26","author":"JS Mohamed","year":"2012","unstructured":"Mohamed JS, Boriek AM. Loss of desmin triggers mechanosensitivity and up-regulation of Ankrd1 expression through Akt-NF-\u03baB signaling pathway in smooth muscle cells. FASEB J. 2012;26(2):757\u201365. https:\/\/doi.org\/10.1096\/fj.10-160291.","journal-title":"FASEB J"},{"issue":"23","key":"100_CR28","doi-asserted-by":"publisher","first-page":"9764","DOI":"10.1073\/pnas.0700240104","volume":"104","author":"T Oyama","year":"2007","unstructured":"Oyama T, Harigaya K, Muradil A, Hozumi K, Habu S, Oguro H, et al. Mastermind-1 is required for notch signal-dependent steps in lymphocyte development in vivo. Proc Natl Acad Sci U S A. 2007;104(23):9764\u20139. https:\/\/doi.org\/10.1073\/pnas.0700240104.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"100_CR29","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/j.1749-0774.2002.tb00105.x","volume":"15","author":"M Nishida","year":"2002","unstructured":"Nishida M. The Ishikawa cells from birth to the present. Hum Cell. 2002;15(3):104\u201317. https:\/\/doi.org\/10.1111\/j.1749-0774.2002.tb00105.x.","journal-title":"Hum Cell"},{"issue":"2","key":"100_CR30","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1095\/biolreprod.109.077800","volume":"82","author":"NJ Hannan","year":"2010","unstructured":"Hannan NJ, Paiva P, Dimitriadis E, Salamonsen LA. Models for study of human embryo implantation: choice of cell lines? Biol Reprod. 2010;82(2):235\u201345. https:\/\/doi.org\/10.1095\/biolreprod.109.077800.","journal-title":"Biol Reprod"},{"issue":"1","key":"100_CR31","doi-asserted-by":"publisher","first-page":"8644","DOI":"10.1038\/s41598-019-45155-6","volume":"9","author":"M Griffiths","year":"2019","unstructured":"Griffiths M, Van Sinderen M, Rainczuk K, Dimitriadis E. miR-29c overexpression and COL4A1 downregulation in infertile human endometrium reduces endometrial epithelial cell adhesive capacity in vitro implying roles in receptivity. Sci Rep. 2019;9(1):8644. https:\/\/doi.org\/10.1038\/s41598-019-45155-6.","journal-title":"Sci Rep"},{"issue":"1","key":"100_CR32","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1093\/biolre\/ioz173","volume":"102","author":"M Takamura","year":"2019","unstructured":"Takamura M, Zhou W, Rombauts L, Dimitriadis E. The long noncoding RNA PTENP1 regulates human endometrial epithelial adhesive capacity in vitro: implications in infertility. Biol Reprod. 2019;102(1):53\u201362.","journal-title":"Biol Reprod"},{"issue":"4","key":"100_CR33","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.bbrc.2020.07.046","volume":"531","author":"CK Ling","year":"2020","unstructured":"Ling CK, Santos LL, Zhou W, Dimitriadis E. Chloride intracellular channel 4 is dysregulated in endometrium of women with infertility and alters receptivity. Biochem Biophys Res Commun. 2020;531(4):490\u20136. https:\/\/doi.org\/10.1016\/j.bbrc.2020.07.046.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"100_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12958-020-00624-w","volume":"18","author":"W Zhou","year":"2020","unstructured":"Zhou W, Santos L, Dimitriadis E. Characterization of the role for cadherin 6 in the regulation of human endometrial receptivity. Reprod Biol Endocrinol. 2020;18(1):1\u201310.","journal-title":"Reprod Biol Endocrinol"},{"key":"100_CR35","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jneumeth.2017.02.002","volume":"280","author":"AM Kopec","year":"2017","unstructured":"Kopec AM, Rivera PD, Lacagnina MJ, Hanamsagar R, Bilbo SD. Optimized solubilization of TRIzol-precipitated protein permits Western blotting analysis to maximize data available from brain tissue. J Neurosci Methods. 2017;280:64\u201376. https:\/\/doi.org\/10.1016\/j.jneumeth.2017.02.002.","journal-title":"J Neurosci Methods"},{"issue":"10","key":"100_CR36","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1093\/molehr\/gax044","volume":"23","author":"W Zhou","year":"2017","unstructured":"Zhou W, Anderson AL, Turner AP, De Iuliis GN, McCluskey A, McLaughlin EA, et al. Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis. Mol Hum Reprod. 2017;23(10):657\u201373. https:\/\/doi.org\/10.1093\/molehr\/gax044.","journal-title":"Mol Hum Reprod"},{"issue":"10","key":"100_CR37","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1007\/s00018-009-8668-7","volume":"66","author":"T Borggrefe","year":"2009","unstructured":"Borggrefe T, Oswald F. The notch signaling pathway: transcriptional regulation at notch target genes. Cell Mol Life Sci. 2009;66(10):1631\u201346. https:\/\/doi.org\/10.1007\/s00018-009-8668-7.","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"100_CR38","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.fertnstert.2010.04.063","volume":"95","author":"P D\u00edaz-Gimeno","year":"2011","unstructured":"D\u00edaz-Gimeno P, Horcajadas JA, Mart\u00ednez-Conejero JA, Esteban FJ, Alam\u00e1 P, Pellicer A, et al. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril. 2011;95(1):50\u201360. https:\/\/doi.org\/10.1016\/j.fertnstert.2010.04.063.","journal-title":"Fertil Steril"},{"issue":"8","key":"100_CR39","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1093\/molehr\/gal019","volume":"12","author":"Y Shimomura","year":"2006","unstructured":"Shimomura Y, Ando H, Furugori K, Kajiyama H, Suzuki M, Iwase A, et al. Possible involvement of crosstalk cell-adhesion mechanism by endometrial CD26\/dipeptidyl peptidase IV and embryonal fibronectin in human blastocyst implantation. Mol Hum Reprod. 2006;12(8):491\u20135. https:\/\/doi.org\/10.1093\/molehr\/gal019.","journal-title":"Mol Hum Reprod"},{"issue":"1","key":"100_CR40","doi-asserted-by":"publisher","first-page":"10077","DOI":"10.1038\/s41598-017-10098-3","volume":"7","author":"S Altm\u00e4e","year":"2017","unstructured":"Altm\u00e4e S, Koel M, V\u00f5sa U, Adler P, Suhorut\u0161enko M, Laisk-Podar T, et al. Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers. Sci Rep. 2017;7(1):10077. https:\/\/doi.org\/10.1038\/s41598-017-10098-3.","journal-title":"Sci Rep"},{"issue":"1","key":"100_CR41","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/2049-1891-5-56","volume":"5","author":"GA Johnson","year":"2014","unstructured":"Johnson GA, Burghardt RC, Bazer FW. Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep. J Anim Sci Biotechnol. 2014;5(1):56. https:\/\/doi.org\/10.1186\/2049-1891-5-56.","journal-title":"J Anim Sci Biotechnol"},{"issue":"1","key":"100_CR42","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0165-0378(01)00139-5","volume":"55","author":"BA Lessey","year":"2002","unstructured":"Lessey BA. Adhesion molecules and implantation. J Reprod Immunol. 2002;55(1):101\u201312. https:\/\/doi.org\/10.1016\/S0165-0378(01)00139-5.","journal-title":"J Reprod Immunol"},{"issue":"1","key":"100_CR43","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.ejogrb.2013.06.019","volume":"170","author":"N Liu","year":"2013","unstructured":"Liu N, Zhou C, Chen Y, Zhao J. The involvement of osteopontin and \u03b23 integrin in implantation and endometrial receptivity in an early mouse pregnancy model. Eur J Obstet Gynecol Reprod Biol. 2013;170(1):171\u20136. https:\/\/doi.org\/10.1016\/j.ejogrb.2013.06.019.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"8","key":"100_CR44","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1093\/humrep\/dei051","volume":"20","author":"S Mirkin","year":"2005","unstructured":"Mirkin S, Arslan M, Churikov D, Corica A, Diaz JI, Williams S, et al. In search of candidate genes critically expressed in the human endometrium during the window of implantation. Hum Reprod. 2005;20(8):2104\u201317. https:\/\/doi.org\/10.1093\/humrep\/dei051.","journal-title":"Hum Reprod"},{"issue":"4","key":"100_CR45","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/S0015-0282(01)02015-5","volume":"76","author":"M von Wolff","year":"2001","unstructured":"von Wolff M, Strowitzki T, Becker V, Zepf C, Tabibzadeh S, Thaler CJ. Endometrial osteopontin, a ligand of \u03923-integrin, is maximally expressed around the time of the 'implantation window'. Fertil Steril. 2001;76(4):775\u201381. https:\/\/doi.org\/10.1016\/S0015-0282(01)02015-5.","journal-title":"Fertil Steril"},{"issue":"10","key":"100_CR46","first-page":"4991","volume":"86","author":"KBC Apparao","year":"2001","unstructured":"Apparao KBC, Murray MJ, Fritz MA, Meyer WR, Chambers AF, Truong PR, et al. Osteopontin and its receptor \u03b1v\u03b23 integrin are Coexpressed in the human endometrium during the menstrual cycle but regulated differentially. J Clin Endocrinol Metab. 2001;86(10):4991\u20135000.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"100_CR47","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1093\/humupd\/dml046","volume":"13","author":"J Horcajadas","year":"2007","unstructured":"Horcajadas J, Pellicer A, Simon C. Wide genomic analysis of human endometrial receptivity: new times, new opportunities. Hum Reprod Update. 2007;13(1):77\u201386. https:\/\/doi.org\/10.1093\/humupd\/dml046.","journal-title":"Hum Reprod Update"},{"issue":"5","key":"100_CR48","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1095\/biolreprod.109.078600","volume":"81","author":"DW Erikson","year":"2009","unstructured":"Erikson DW, Burghardt RC, Bayless KJ, Johnson GA. Secreted phosphoprotein 1 (SPP1, osteopontin) binds to integrin alphavbeta6 on porcine trophectoderm cells and integrin alphavbeta3 on uterine luminal epithelial cells, and promotes trophectoderm cell adhesion and migration. Biol Reprod. 2009;81(5):814\u201325. https:\/\/doi.org\/10.1095\/biolreprod.109.078600.","journal-title":"Biol Reprod"},{"issue":"3","key":"100_CR49","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1080\/14647273.2017.1324180","volume":"21","author":"C Shi","year":"2018","unstructured":"Shi C, Han HJ, Fan LJ, Guan J, Zheng XB, Chen X, et al. Diverse endometrial mRNA signatures during the window of implantation in patients with repeated implantation failure. Hum Fertil (Camb). 2018;21(3):183\u201394.","journal-title":"Hum Fertil (Camb)"},{"issue":"9","key":"100_CR50","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1093\/oxfordjournals.humrep.a137824","volume":"7","author":"K Imai","year":"1992","unstructured":"Imai K, Maeda M, Fjjiwara K, Kariya M, Takakura K, Kanzaki H, et al. Dipeptidyl peptidase IV as a differentiation marker of human endometrial glandular cells. Hum Reprod. 1992;7(9):1189\u201394. https:\/\/doi.org\/10.1093\/oxfordjournals.humrep.a137824.","journal-title":"Hum Reprod"},{"issue":"49","key":"100_CR51","doi-asserted-by":"publisher","first-page":"40589","DOI":"10.1074\/jbc.M504166200","volume":"280","author":"Q Shen","year":"2005","unstructured":"Shen Q, Christakos S. The vitamin D receptor, Runx2, and the notch signaling pathway cooperate in the transcriptional regulation of osteopontin. J Biol Chem. 2005;280(49):40589\u201398. https:\/\/doi.org\/10.1074\/jbc.M504166200.","journal-title":"J Biol Chem"},{"issue":"6","key":"100_CR52","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1053\/j.gastro.2012.09.002","volume":"143","author":"A Villanueva","year":"2012","unstructured":"Villanueva A, Alsinet C, Yanger K, Hoshida Y, Zong Y, Toffanin S, et al. Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice. Gastroenterology. 2012;143(6):1660\u20139 e1667.","journal-title":"Gastroenterology"},{"issue":"3","key":"100_CR53","first-page":"287","volume":"159","author":"M Kitagawa","year":"2016","unstructured":"Kitagawa M. Notch signalling in the nucleus: roles of mastermind-like (MAML) transcriptional coactivators. J Biochem. 2016;159(3):287\u201394.","journal-title":"J Biochem"},{"issue":"4","key":"100_CR54","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.bbrc.2008.05.079","volume":"372","author":"S Kang","year":"2008","unstructured":"Kang S, Yang C, Luo R. Induction of CCL2 by siMAML1 through upregulation of TweakR in melanoma cells. Biochem Biophys Res Commun. 2008;372(4):629\u201333. https:\/\/doi.org\/10.1016\/j.bbrc.2008.05.079.","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"100_CR55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120547","volume":"10","author":"K W\u00f6ltje","year":"2015","unstructured":"W\u00f6ltje K, Jabs M, Fischer A. Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not notch signaling in endothelial cells. PLoS One. 2015;10(3):e0120547. https:\/\/doi.org\/10.1371\/journal.pone.0120547.","journal-title":"PLoS One"},{"issue":"606","key":"100_CR56","doi-asserted-by":"publisher","first-page":"eaay2369","DOI":"10.1126\/scisignal.aay2369","volume":"12","author":"SM Jarrett","year":"2019","unstructured":"Jarrett SM, Seegar TCM, Andrews M, Adelmant G, Marto JA, Aster JC, et al. Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. Sci Signal. 2019;12(606):eaay2369.","journal-title":"Sci Signal"},{"issue":"15","key":"100_CR57","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1101\/gad.908101","volume":"15","author":"E Lamar","year":"2001","unstructured":"Lamar E, Deblandre G, Wettstein D, Gawantka V, Pollet N, Niehrs C, et al. Nrarp is a novel intracellular component of the notch signaling pathway. Genes Dev. 2001;15(15):1885\u201399. https:\/\/doi.org\/10.1101\/gad.908101.","journal-title":"Genes Dev"},{"key":"100_CR58","doi-asserted-by":"crossref","unstructured":"Murata A, Hayashi S: Notch-Mediated Cell Adhesion. Biology (Basel) 2016, 5(1).","DOI":"10.3390\/biology5010005"},{"issue":"4","key":"100_CR59","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1071\/RD15313","volume":"29","author":"M Van Sinderen","year":"2017","unstructured":"Van Sinderen M, Oyanedel J, Menkhorst E, Cuman C, Rainczuk K, Winship A, et al. Soluble Delta-like ligand 1 alters human endometrial epithelial cell adhesive capacity. Reprod Fertil Dev. 2017;29(4):694\u2013702. https:\/\/doi.org\/10.1071\/RD15313.","journal-title":"Reprod Fertil Dev"},{"key":"100_CR60","doi-asserted-by":"publisher","first-page":"534","DOI":"10.3389\/fgene.2019.00534","volume":"10","author":"T Barhoumi","year":"2019","unstructured":"Barhoumi T, Nashabat M, Alghanem B, Alhallaj A, Boudjelal M, Umair M, et al. Delta Like-1 gene mutation: a novel cause of congenital vertebral malformation. Front Genet. 2019;10:534. https:\/\/doi.org\/10.3389\/fgene.2019.00534.","journal-title":"Front Genet"},{"issue":"38","key":"100_CR61","doi-asserted-by":"publisher","first-page":"5138","DOI":"10.1038\/onc.2008.228","volume":"27","author":"AS McElhinny","year":"2008","unstructured":"McElhinny AS, Li JL, Wu L. Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways. Oncogene. 2008;27(38):5138\u201347. https:\/\/doi.org\/10.1038\/onc.2008.228.","journal-title":"Oncogene"},{"issue":"2","key":"100_CR62","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.devcel.2018.03.019","volume":"45","author":"Y Xiao","year":"2018","unstructured":"Xiao Y, Hill MC, Zhang M, Martin TJ, Morikawa Y, Wang S, et al. Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development. Dev Cell. 2018;45(2):153\u201369 e156.","journal-title":"Dev Cell"},{"issue":"1","key":"100_CR63","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12867-015-0047-3","volume":"16","author":"Y Lu","year":"2015","unstructured":"Lu Y, Li J, Cheng J, Lubahn DB. Genes targeted by the hedgehog-signaling pathway can be regulated by estrogen related receptor \u03b2. BMC Mol Biol. 2015;16(1):19. https:\/\/doi.org\/10.1186\/s12867-015-0047-3.","journal-title":"BMC Mol Biol"}],"container-title":["Fertility Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40738-021-00100-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40738-021-00100-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40738-021-00100-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T06:03:16Z","timestamp":1616824996000},"score":1,"resource":{"primary":{"URL":"https:\/\/fertilityresearchandpractice.biomedcentral.com\/articles\/10.1186\/s40738-021-00100-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,27]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["100"],"URL":"https:\/\/doi.org\/10.1186\/s40738-021-00100-y","relation":{},"ISSN":["2054-7099"],"issn-type":[{"type":"electronic","value":"2054-7099"}],"subject":[],"published":{"date-parts":[[2021,3,27]]},"assertion":[{"value":"2 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from each patient and the study was approved by the Human Research Ethics Committee at Monash Health (#03066B) and the Royal Women\u2019s Hospital (ID: SSA1813).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors report no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8"}}