{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:35:17Z","timestamp":1762544117437,"version":"3.35.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Pharm Health Care Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Stroke is a leading cause of death, reducing disability-free life expectancy. After acute treatment, patients require rehabilitation to prevent recurrence. Continued use of medication is crucial for recurrence prevention and risk management, even after the transition from acute-care institutions to other medical institutions. Although \u201cdischarge summaries on medications\u201d are shared between hospitals and community pharmacists, no reports have addressed medication continuity for patients with stroke transferred to other institutions after discharge. This study aimed to clarify medication continuity, particularly for medications adjusted during hospitalization that should be continued even after discharge, by investigating the medication use histories of patients with stroke transferred from acute care hospitals to outpatient hospitals.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We enrolled patients who were discharged from an acute ward between June 11, 2022, and March 31, 2023, after receiving inpatient care at the Japan Community Healthcare Organization, Hoshigaoka Medical Center for acute stroke, and transferred to other outpatient hospitals. This study was conducted between June 2022 and April 2023. We extracted and assessed prescription continuity and carefully examined clinically relevant discrepancies after comparing the discharge prescription with that at the first outpatient visit.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Of the 42 patients enrolled, seven (16.7%) had one or more discrepancies involving 13 medications. Based on the medicinal efficacy classification, four patients treated with other blood and body fluids-related agents (antiplatelet drugs), three patients treated with agents for hyperlipidemia (statins), two patients with agents for peptic ulcers, two patients with vasodilators, one patient treated with antihypertensives, and one patient with other agents affecting digestive organs (antiemetic agents that acts on the central nervous system) had discrepancies. Furthermore, discrepancies in\u00a0medication discontinuation or reduction recommended by\u00a0a stroke specialist, which may increase the risk of stroke recurrence, were identified in five patients (seven drugs: four antiplatelet drugs and\u00a0three statins). Of 13 discrepancies, community pharmacists inquired about 3 cases with physicians, none were approved.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The medication to prevent stroke recurrence might not be continued after transit to another outpatient after discharge. Reconsidering patient information sharing between hospital and community pharmacists and establishing a more strengthened sharing system is necessary to achieve seamless pharmacotherapy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s40780-025-00415-8","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T07:59:51Z","timestamp":1738569591000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Survey of medication history of patients with stroke after discharge from an acute hospital ward: a case series study"],"prefix":"10.1186","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6516-8797","authenticated-orcid":false,"given":"Yuko","family":"Fukuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risa","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misaki","family":"Kakihana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuji","family":"Kanemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Sahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Tsujikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuko","family":"Onda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"415_CR1","unstructured":"Ministry of Health and Welfare. Summary of estimates of national medical care expenditure; 2021. https:\/\/www.mhlw.go.jp\/toukei\/saikin\/hw\/k-iryohi\/21\/dl\/kekka.pdf. Accessed 3 May 2024."},{"key":"415_CR2","unstructured":"Ministry of Health and Welfare. Summary of vital statistics 2022; 2022. https:\/\/www.mhlw.go.jp\/toukei\/saikin\/hw\/jinkou\/kakutei22\/dl\/10_h6.pdf. Accessed 3 May 2024."},{"key":"415_CR3","unstructured":"Ministry of Health and Welfare Summary report of a\u00a0comprehensive survey of living conditions 2022; 2022. https:\/\/www.mhlw.go.jp\/toukei\/saikin\/hw\/k-tyosa\/k-tyosa22\/dl\/05.pdf. Accessed 3 May 2024."},{"key":"415_CR4","unstructured":"The stroke\/cerebrovascular and cardiovascular disease control act (act No. 105 of December 14, 2018). https:\/\/houseikyoku.sangiin.go.jp\/bill\/pdf\/h30-105.pdf. Accessed 6 May 2024."},{"key":"415_CR5","unstructured":"All Japan Hospital Association. Usage rate of the liaison critical pathway for stroke. https:\/\/www.ajha.or.jp\/hms\/qualityhealthcare\/pdf\/2023\/10-12\/2023c_outcome_acute_14.pdf. Accessed 6 May 2024."},{"key":"415_CR6","doi-asserted-by":"publisher","first-page":"161","DOI":"10.7326\/0003-4819-138-3-200302040-00007","volume":"138","author":"AJ Forster","year":"2003","unstructured":"Forster AJ, Murff HJ, Peterson JF, Gandhi TK, Bates DW. The incidence and severity of adverse events affecting patients after discharge from the hospital. Ann Intern Med. 2003;138:161\u20137. https:\/\/doi.org\/10.7326\/0003-4819-138-3-200302040-00007.","journal-title":"Ann Intern Med"},{"key":"415_CR7","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1046\/j.1525-1497.2003.20722.x","volume":"18","author":"C Moore","year":"2003","unstructured":"Moore C, Wisnivesky J, Williams S, McGinn T. Medical errors related to discontinuity of care from an inpatient to an outpatient setting. J Gen Intern Med. 2003;18:646\u201351. https:\/\/doi.org\/10.1046\/j.1525-1497.2003.20722.x.","journal-title":"J Gen Intern Med"},{"key":"415_CR8","doi-asserted-by":"publisher","unstructured":"Shinmori K, Kimura T, Matsumura S. A concept of \u201ctransition of care\u201d in Japan -focusing on care transition of patients who are discharged from a hospital and treated at another clinic as an outpatient. An Off. J. Japan Prim. Care Assoc.2018;41:18\u201323. https:\/\/doi.org\/10.14442\/generalist.41.18.","DOI":"10.14442\/generalist.41.18"},{"key":"415_CR9","first-page":"637","volume":"55","author":"R Suzuki","year":"2019","unstructured":"Suzuki R, Kakigoshi S, Sago K, Wakita E, Nakamura A, Hirano A, et al. Evaluation of information sharing between hospital pharmacists and community pharmacists using information liaison forms. J Jpn Soc Hosp Pharm. 2019;55:637\u201342.","journal-title":"J Jpn Soc Hosp Pharm"},{"key":"415_CR10","first-page":"757","volume":"57","author":"Y Ishihara","year":"2021","unstructured":"Ishihara Y, Nishikori K, Fujihara R, Kageyama S, Funo Y, Ajiki KI, et al. The preparation and evaluation of discharge summaries containing a medication report specifying the reasons for changes in prescriptions. J Jpn Soc Hosp Pharm. 2021;57:757\u201364.","journal-title":"J Jpn Soc Hosp Pharm"},{"key":"415_CR11","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1248\/yakushi.23-00214","volume":"144","author":"Y Fukuda","year":"2024","unstructured":"Fukuda Y, Suzuki M, Ito R, Inaba J, Kanemoto T, Sahara T, et al. Utilization and issues related to discharge medication summaries from hospital pharmacies to community pharmacies. Yakugaku Zasshi. 2024;144:741\u20138. https:\/\/doi.org\/10.1248\/yakushi.23-00214.","journal-title":"Yakugaku Zasshi"},{"key":"415_CR12","unstructured":"Medications covered by insurance dictionary plus+ with indications and dosage, the NHI drug price standard by drug efficacy, 2022 edition. Jiho Yakugyo Kenkyukai. 2022."},{"key":"415_CR13","unstructured":"Chino N, Riu M. Functional evaluation of stroke patients: The practicalities of SIAS and FIM. Springer-Verlag Tokyo; 1997."},{"key":"415_CR14","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1161\/STROKEAHA.112.678847","volume":"44","author":"C Hohmann","year":"2013","unstructured":"Hohmann C, Neumann-Haefelin T, Klotz JM, Freidank A, Radziwill R. Adherence to hospital discharge medication in patients with ischemic stroke: A prospective, interventional 2-phase study. Stroke. 2013;44:522\u20134. https:\/\/doi.org\/10.1161\/STROKEAHA.112.678847. (Epub 2012).","journal-title":"Stroke"},{"key":"415_CR15","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1177\/2150131913518346","volume":"5","author":"J Hamano","year":"2014","unstructured":"Hamano J, Tokuda Y. Inappropriate prescribing among elderly home care patients in Japan: prevalence and risk factors. J Prim Care Community Health. 2014;5:90\u20136. https:\/\/doi.org\/10.1177\/2150131913518346. (Epub 2014).","journal-title":"J Prim Care Community Health"},{"key":"415_CR16","unstructured":"Ministry of Health and Welfare. Guidelines for the appropriate use of medicines in the elderly 2018. https:\/\/www.mhlw.go.jp\/content\/11121000\/kourei-tekisei_web.pdf. Accessed 15 Sep 2024."},{"key":"415_CR17","unstructured":"Japan Atherosclerosis Society (JAS). Guidelines for prevention of atherosclerotic cardiovascular diseases 2022. Japan Atherosclerosis Society; 2022."},{"key":"415_CR18","unstructured":"The Japan Stroke Society, Stroke Guidelines Committee. Japanese guidelines for the management of STROKE 2021, e-book edition. Kyowa Planning Co; 2021."},{"key":"415_CR19","unstructured":"The Japanese Society of Gastroenterology. Evidence-based clinical practice guidelines for peptic ulcer 2020. 3rd ed. Nankodo Co; 2020."}],"container-title":["Journal of Pharmaceutical Health Care and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40780-025-00415-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40780-025-00415-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40780-025-00415-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T07:59:58Z","timestamp":1738569598000},"score":1,"resource":{"primary":{"URL":"https:\/\/jphcs.biomedcentral.com\/articles\/10.1186\/s40780-025-00415-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,3]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["415"],"URL":"https:\/\/doi.org\/10.1186\/s40780-025-00415-8","relation":{},"ISSN":["2055-0294"],"issn-type":[{"value":"2055-0294","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,3]]},"assertion":[{"value":"25 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted with the approval of the JCHO Hoshigaoka Medical Center Clinical Research Review Committee (approval number: 2226) and in accordance with the Ethical Guidelines for Medical and Health Research Involving Human Subjects.Before implementing the study, we provided the research subjects with a document that had been approved by the Clinical Research Review Committee and obtained written consent to participate in this study. Patients with the target disease may have included those who had difficulty communicating. Therefore, making a decision would be difficult for these patients; hence, consent was obtained from the substitute decision maker. The substitute decision-maker was defined as a spouse, parent, sibling, child, grandchild, grandparent, or relative living together; someone considered to be equivalent to a close relative; a representative of the participants (including voluntary guardians with a power of attorney); or a person in a mental relationship of partnership or trust.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10"}}