{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:38:15Z","timestamp":1769517495614,"version":"3.49.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsmedizin Rostock"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Pharm Health Care Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Comprehensive medication regimens increase the risk of potential drug-drug interactions, adversely affecting health outcomes regardless of age. This risk is particularly pertinent in the context of medical vocational rehabilitation for middle-aged patients, who aim at facilitating rapid reintegration into employment. Identifying and addressing unfavourable drug regimens may substantially contribute to the effectiveness of interdisciplinary therapeutic interventions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The retrospective cohort study was conducted among middle-aged soldiers diagnosed with post-traumatic stress disorder and at least one physical impairment and long-term medication intake. Patient records were analysed to investigate the nature of the medication such as the number of drugs and distribution according to the anatomical therapeutic code classification and drug-drug interactions in relation to bicycle ergometry performance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A substantial majority (73.2%) of all patients enrolled were prescribed an average of 3.0 (\u00b1\u20092.0) long-term medications per person. All patients received treatments containing ATC N drugs, which exert antidepressant properties. On average, each patient encountered the possible risk of 1.7 (\u00b1\u20091.3) drug interactions. Patients administered at least two ATC N drugs exhibited reduced maximum performance compared to controls. Conversely, patients receiving at least two drugs, wherein only one drug classified as ATC N, did not demonstrate significant performance differences from the control group. Notably, treatments incorporating selective monoamine reuptake inhibitors significantly reduced maximum performance relative to controls. The risk for potential drug-drug interactions, particularly those leading to QT interval prolongation, accounted for 47.5% of interactions involving ATC N drugs. Patients exclusively exposed to potential QT-prolonging interactions exhibited significantly reduced maximum performance compared to controls as well as patients who experienced different potential interactions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Potential drug-drug interactions and disadvantageous drug combinations were prevalent among middle-aged adults with psychiatric disorders and may hinder a positive prognosis for physical fitness. The findings of this study underscore the importance of personalized medication management and continuous monitoring to mitigate negative impacts. Clinicians should diligently review patients\u2019 medication records and adjust therapies accordingly to prevent adverse drug reactions. Proactive strategies, such as regular medication reviews and drug-drug interaction screening tools, may be essential for optimizing therapeutic efficacy and maintaining physical performance.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s40780-025-00422-9","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T16:29:46Z","timestamp":1741019386000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of drug patterns and drug-drug-interactions: associations with physical performance in middle-aged military personnel undergoing rehabilitation\u2013 a retrospective cohort study"],"prefix":"10.1186","volume":"11","author":[{"given":"Jennifer-Daniele","family":"Schmitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Korte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Lison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Ger\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"422_CR1","doi-asserted-by":"crossref","unstructured":"Blessing C, Golden TP, Pi S, Bruy\u00e8re SM, van Looy S. Vocational rehabilitation, inclusion, and social integration. In: Kennedy P, editor. The Oxford handbook of rehabilitation psychology. Oxford University Press; 2012; 453\u201373.","DOI":"10.1093\/oxfordhb\/9780199733989.013.0025"},{"issue":"1","key":"422_CR2","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1186\/s12889-022-13295-6","volume":"22","author":"CJC de Geus","year":"2022","unstructured":"de Geus CJC, Huysmans MA, van Rijssen HJ, Anema JR. Return to work factors and vocational rehabilitation interventions for long-term, partially disabled workers: a modified Delphi study among vocational rehabilitation professionals. BMC Public Health. 2022;22(1):875.","journal-title":"BMC Public Health"},{"key":"422_CR3","unstructured":"Deutsche Rentenversicherung. Medizinisch-beruflich orientierte Rehabilitation: Anforderungsprofil zur Durchf\u00fchrung der Medizinisch-beruflich orientierten Rehabilitation (MBOR) im Auftrag der Deutschen Rentenversicherung 2019."},{"issue":"11","key":"422_CR4","doi-asserted-by":"publisher","first-page":"856","DOI":"10.2340\/16501977-0457","volume":"41","author":"MA Chamberlain","year":"2009","unstructured":"Chamberlain MA, Fialka Moser V, Sch\u00fcldt Ekholm K, O\u2019Connor RJ, Herceg M, Ekholm J. Vocational rehabilitation: an educational review. J Rehabil Med. 2009;41(11):856\u201369.","journal-title":"J Rehabil Med"},{"issue":"10","key":"422_CR5","doi-asserted-by":"publisher","first-page":"796","DOI":"10.2340\/16501977-0270","volume":"40","author":"J Kuoppala","year":"2008","unstructured":"Kuoppala J, Lamminp\u00e4\u00e4 A. Rehabilitation and work ability: a systematic literature review. J Rehabil Med. 2008;40(10):796\u2013804.","journal-title":"J Rehabil Med"},{"issue":"14","key":"422_CR6","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1080\/09638280210124284","volume":"24","author":"J Selander","year":"2002","unstructured":"Selander J, Marnetoft S-U, Bergroth A, Ekholm J. Return to work following vocational rehabilitation for neck, back and shoulder problems: risk factors reviewed. Disabil Rehabil. 2002;24(14):704\u201312.","journal-title":"Disabil Rehabil"},{"issue":"7","key":"422_CR7","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1055\/s-2000-8822","volume":"50","author":"MC H\u00e4rter","year":"2000","unstructured":"H\u00e4rter MC. Psychische st\u00f6rungen Bei K\u00f6rperlichen erkrankungen. Psychother Psychosom Med Psychol. 2000;50(7):274\u201386.","journal-title":"Psychother Psychosom Med Psychol"},{"issue":"9","key":"422_CR8","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1007\/s11606-019-05106-3","volume":"34","author":"A Katsimpris","year":"2019","unstructured":"Katsimpris A, Linseisen J, Meisinger C, Volaklis K. The association between polypharmacy and physical function in older adults: a systematic review. J Gen Intern Med. 2019;34(9):1865\u201373.","journal-title":"J Gen Intern Med"},{"issue":"Suppl 1","key":"422_CR9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/BF03319101","volume":"35","author":"F Salvi","year":"2012","unstructured":"Salvi F, Marchetti A, D\u2019Angelo F, Boemi M, Lattanzio F, Cherubini A. Adverse drug events as a cause of hospitalization in older adults. Drug Saf. 2012;35(Suppl 1):29\u201345.","journal-title":"Drug Saf"},{"issue":"9237","key":"422_CR10","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1016\/S0140-6736(00)02799-9","volume":"356","author":"IR Edwards","year":"2000","unstructured":"Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet. 2000;356(9237):1255\u20139.","journal-title":"Lancet"},{"issue":"6","key":"422_CR11","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1002\/cpt.1434","volume":"105","author":"J Niu","year":"2019","unstructured":"Niu J, Straubinger RM, Mager DE. Pharmacodynamic Drug-Drug interactions. Clin Pharmacol Ther. 2019;105(6):1395\u2013406.","journal-title":"Clin Pharmacol Ther"},{"issue":"7","key":"422_CR12","first-page":"601","volume":"18","author":"C Palleria","year":"2013","unstructured":"Palleria C, Di Paolo A, Giofr\u00e8 C, Caglioti C, Leuzzi G, Siniscalchi A, et al. Pharmacokinetic drug-drug interaction and their implication in clinical management. J Res Med Sci. 2013;18(7):601\u201310.","journal-title":"J Res Med Sci"},{"issue":"1","key":"422_CR13","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1186\/s12877-022-03548-9","volume":"22","author":"CE Aubert","year":"2022","unstructured":"Aubert CE, Kabeto M, Kumar N, Wei MY. Multimorbidity and long-term disability and physical functioning decline in middle-aged and older Americans: an observational study. BMC Geriatr. 2022;22(1):910.","journal-title":"BMC Geriatr"},{"issue":"10","key":"422_CR14","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1016\/j.jamda.2021.03.019","volume":"22","author":"P Anrys","year":"2021","unstructured":"Anrys P, Petit A-E, Thevelin S, Sallevelt B, Drenth C, Soiza RL, et al. An international consensus list of potentially clinically significant Drug-Drug interactions in older people. J Am Med Dir Assoc. 2021;22(10):2121\u2013e213324.","journal-title":"J Am Med Dir Assoc"},{"key":"422_CR15","volume-title":"Sportmedizin und Pr\u00e4vention. S1","year":"2007","unstructured":"Deutsche Gesellschaft f\u00fcr Sportmedizin und Pr\u00e4vention. S1 - Leitlinie: Vorsorgeuntersuchung im Sport; 2007."},{"key":"422_CR16","doi-asserted-by":"crossref","unstructured":"Schulze C, Becker M, Finze S, Holtherm C, Hinder J, Lison A. An Evaluation of the Significance of Work-Related Influence Factors on Fitness and the Development of Medical and Orthopaedic Conditions in Military Executives. ScientificWorldJournal. 2016; 2016:3929104.","DOI":"10.1155\/2016\/3929104"},{"issue":"1","key":"422_CR17","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1186\/s12877-017-0621-2","volume":"17","author":"N Masnoon","year":"2017","unstructured":"Masnoon N, Shakib S, Kalisch-Ellett, Lea. What is polypharmacy? A systematic review of definitions. BMC Geriatr. 2017;17(1):230.","journal-title":"BMC Geriatr"},{"issue":"07\/08","key":"422_CR18","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1055\/s-0037-1616408","volume":"35","author":"F Illes","year":"2016","unstructured":"Illes F, Uhl I, Posttraumatische. Belastungsst\u00f6rung Und Depress Nervenheilkunde. 2016;35(07\/08):474\u201380.","journal-title":"Belastungsst\u00f6rung Und Depress Nervenheilkunde"},{"key":"422_CR19","unstructured":"Deutsche Rentenversicherung. Psychische Kormorbidit\u00e4t [Sozialmedizin und Rehabilitation] [cited 2023 Feb 12]."},{"key":"422_CR20","volume-title":"PTBS und KPTBS: Ein Leitfaden f\u00fcr die diagnostik und behandlung","author":"M Augsburger","year":"2020","unstructured":"Augsburger M, Maercker A, Posttraumatische, Belastungsst\u00f6rungen. PTBS und KPTBS: Ein Leitfaden f\u00fcr die diagnostik und behandlung. Stuttgart: Kohlhammer; 2020. (St\u00f6rungsspezifische Psychotherapie)."},{"issue":"1","key":"422_CR21","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2174\/157488610789869265","volume":"5","author":"PA Alvarez","year":"2010","unstructured":"Alvarez PA, Pahissa J. QT alterations in psychopharmacology: proven candidates and suspects. Curr Drug Saf. 2010;5(1):97\u2013104.","journal-title":"Curr Drug Saf"},{"key":"422_CR22","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.bbrc.2023.09.043","volume":"681","author":"M Nemati","year":"2023","unstructured":"Nemati M, Hosseinzadeh Z, Nemati F, Ebrahimi B. Impact of antipsychotics and antidepressants drugs on long QT syndrome induction related to hERG channel dysfunction: A systematic review. Biochem Biophys Res Commun. 2023;681:90\u20136.","journal-title":"Biochem Biophys Res Commun"},{"issue":"Suppl 4","key":"422_CR23","first-page":"4","volume":"60","author":"JP Feighner","year":"1999","unstructured":"Feighner JP. Mechanism of action of antidepressant medications. J Clin Psychiatry. 1999;60(Suppl 4):4\u201311. discussion 12\u2013\u20093.","journal-title":"J Clin Psychiatry"},{"issue":"3","key":"422_CR24","first-page":"148","volume":"22","author":"S Madhusoodanan","year":"2010","unstructured":"Madhusoodanan S, Alexeenko L, Sanders R, Brenner R. Extrapyramidal symptoms associated with antidepressants\u2013a review of the literature and an analysis of spontaneous reports. Ann Clin Psychiatry. 2010;22(3):148\u201356.","journal-title":"Ann Clin Psychiatry"},{"issue":"8","key":"422_CR25","first-page":"1505","volume":"13","author":"L Sep\u00falveda-Lizcano","year":"2023","unstructured":"Sep\u00falveda-Lizcano L, Arenas-Villamizar VV, Jaimes-Duarte EB, Garc\u00eda-Pacheco H, Paredes CS, Berm\u00fadez V, et al. Metabolic adverse effects of psychotropic drug therapy: A systematic review. Eur J Investig Health Psychol Educ. 2023;13(8):1505\u201320.","journal-title":"Eur J Investig Health Psychol Educ"},{"issue":"1\u20132","key":"422_CR26","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.jad.2010.06.028","volume":"128","author":"U Voderholzer","year":"2011","unstructured":"Voderholzer U, Dersch R, Dickhut HH, Herter A, Freyer T, Berger M. Physical fitness in depressive patients and impact of illness course and disability. J Affect Disord. 2011;128(1\u20132):160\u20134.","journal-title":"J Affect Disord"},{"issue":"4","key":"422_CR27","doi-asserted-by":"publisher","first-page":"409","DOI":"10.31887\/DCNS.2008.10.4\/kkelly","volume":"10","author":"K Kelly","year":"2008","unstructured":"Kelly K, Posternak M, Alpert JE. Toward achieving optimal response: Understanding and managing antidepressant side effects. Dialogues Clin Neurosci. 2008;10(4):409\u201318.","journal-title":"Dialogues Clin Neurosci"},{"issue":"8","key":"422_CR28","first-page":"390","volume":"76","author":"I Samard\u017ei\u0107","year":"2021","unstructured":"Samard\u017ei\u0107 I, Marinovi\u0107 I, Ku\u010da N, Vrca VB. Potential clinically significant drug-drug interactions in prescribed pharmacotherapy in an outpatient setting. Pharmazie. 2021;76(8):390\u20135.","journal-title":"Pharmazie"},{"issue":"1","key":"422_CR29","doi-asserted-by":"publisher","first-page":"12","DOI":"10.18773\/austprescr.2020.064","volume":"44","author":"P Boyce","year":"2021","unstructured":"Boyce P, Ma C. Choosing an antidepressant. Aust Prescr. 2021;44(1):12\u20135.","journal-title":"Aust Prescr"},{"issue":"11","key":"422_CR30","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.biopsych.2007.03.027","volume":"62","author":"GI Papakostas","year":"2007","unstructured":"Papakostas GI, Thase ME, Fava M, Nelson JC, Shelton RC. Are antidepressant drugs that combine serotonergic and noradrenergic mechanisms of action more effective than the selective serotonin reuptake inhibitors in treating major depressive disorder? A meta-analysis of studies of newer agents. Biol Psychiatry Glob Open Sci. 2007;62(11):1217\u201327.","journal-title":"Biol Psychiatry Glob Open Sci"},{"issue":"4","key":"422_CR31","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1097\/YIC.0000000000000023","volume":"29","author":"C Sanchez","year":"2014","unstructured":"Sanchez C, Reines EH, Montgomery SA. A comparative review of Escitalopram, Paroxetine, and Sertraline: are they all alike? Int Clin Psychopharmacol. 2014;29(4):185\u201396.","journal-title":"Int Clin Psychopharmacol"},{"issue":"4","key":"422_CR32","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3949\/ccjm.73.4.351","volume":"73","author":"EA Khawam","year":"2006","unstructured":"Khawam EA, Laurencic G, Malone DA. Side effects of antidepressants: an overview. Cleve Clin J Med. 2006;73(4):351\u20133. 356\u2013\u200961.","journal-title":"Cleve Clin J Med"},{"issue":"1","key":"422_CR33","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1186\/s12877-021-02183-0","volume":"21","author":"M Sheikh-Taha","year":"2021","unstructured":"Sheikh-Taha M, Asmar M. Polypharmacy and severe potential drug-drug interactions among older adults with cardiovascular disease in the united States. BMC Geriatr. 2021;21(1):233.","journal-title":"BMC Geriatr"},{"issue":"15","key":"422_CR34","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1053\/euhj.2000.2249","volume":"21","author":"W Haverkamp","year":"2000","unstructured":"Haverkamp W, Breithardt G, Camm AJ, Janse MJ, Rosen MR, Antzelevitch C, et al. The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications. Eur Heart J. 2000;21(15):1216\u201331. Report on a policy conference of the European Society of Cardiology.","journal-title":"Eur Heart J"},{"issue":"11","key":"422_CR35","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.2165\/00003495-200262110-00006","volume":"62","author":"PM Haddad","year":"2002","unstructured":"Haddad PM, Anderson IM. Antipsychotic-related QTc prolongation, torsade de pointes and sudden death. Drugs. 2002;62(11):1649\u201371.","journal-title":"Drugs"},{"issue":"1","key":"422_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1744-859X-4-1","volume":"4","author":"M Sala","year":"2005","unstructured":"Sala M, Vicentini A, Brambilla P, Montomoli C, Jogia JR, Caverzasi E, et al. QT interval prolongation related to psychoactive drug treatment: a comparison of monotherapy versus polytherapy. Ann Gen Psychiatry. 2005;4(1):1.","journal-title":"Ann Gen Psychiatry"},{"issue":"12","key":"422_CR37","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1007\/s00228-018-2537-y","volume":"74","author":"R de Vecchis","year":"2018","unstructured":"de Vecchis R, Ariano C, Di Biase G, Noutsias M. Acquired drug-induced long QTc: new insights coming from a retrospective study. Eur J Clin Pharmacol. 2018;74(12):1645\u201351.","journal-title":"Eur J Clin Pharmacol"},{"issue":"9","key":"422_CR38","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1001\/jamacardio.2018.2251","volume":"3","author":"J-E Salem","year":"2018","unstructured":"Salem J-E, Dureau P, Bachelot A, Germain M, Voiriot P, Lebourgeois B, et al. Association of oral contraceptives with Drug-Induced QT interval prolongation in healthy nonmenopausal women. JAMA Cardiol. 2018;3(9):877\u201382.","journal-title":"JAMA Cardiol"},{"issue":"2","key":"422_CR39","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.psym.2017.10.009","volume":"59","author":"SR Beach","year":"2018","unstructured":"Beach SR, Celano CM, Sugrue AM, Adams C, Ackerman MJ, Noseworthy PA, et al. QT prolongation, Torsades de pointes, and psychotropic medications: A 5-Year update. Psychosomatics. 2018;59(2):105\u201322.","journal-title":"Psychosomatics"},{"key":"422_CR40","doi-asserted-by":"crossref","unstructured":"Gerber W, Steyn JD, Kotz\u00e9 AF, Hamman JH. Beneficial Pharmacokinetic drug interactions: A tool to improve the bioavailability of poorly permeable drugs. Pharmaceutics 2018; 10(3).","DOI":"10.3390\/pharmaceutics10030106"},{"key":"422_CR41","unstructured":"Bschor T, Gehrisch J, Nagel L-T. Leitliniengerechte Pharmakotherapie Der Depress Arzneiverordnung Der Praxis 2018; (3)."},{"key":"422_CR42","unstructured":"Sch\u00e4fer I, Gast U, Hofmann A, Knaevelsrud C, Lampe A, Liebermann P, Lotzin A. S3-Leitlinie Posttraumatische Belastungsst\u00f6rung 2009."},{"issue":"7","key":"422_CR43","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1097\/PSY.0b013e318148c19a","volume":"69","author":"JA Blumenthal","year":"2007","unstructured":"Blumenthal JA, Babyak MA, Doraiswamy PM, Watkins L, Hoffman BM, Barbour KA, et al. Exercise and pharmacotherapy in the treatment of major depressive disorder. Psychosom Med. 2007;69(7):587\u201396.","journal-title":"Psychosom Med"},{"issue":"10128","key":"422_CR44","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/S0140-6736(17)32802-7","volume":"391","author":"A Cipriani","year":"2018","unstructured":"Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet. 2018;391(10128):1357\u201366.","journal-title":"Lancet"},{"issue":"4","key":"422_CR45","doi-asserted-by":"publisher","first-page":"265","DOI":"10.2188\/jea.JE20190248","volume":"31","author":"Y Komazawa","year":"2021","unstructured":"Komazawa Y, Murayama H, Harata N, Takami K, Parady GT. Role of social support in the relationship between financial strain and frequency of exercise among older Japanese: A 19-year longitudinal study. J Epidemiol. 2021;31(4):265\u201371.","journal-title":"J Epidemiol"},{"issue":"Suppl 11","key":"422_CR46","first-page":"S299","volume":"17","author":"GJ Fanciullo","year":"2011","unstructured":"Fanciullo GJ, Washington T. Best practices to reduce the risk of drug-drug interactions: opportunities for managed care. Am J Manag Care. 2011;17(Suppl 11):S299\u2013304.","journal-title":"Am J Manag Care"},{"issue":"44","key":"422_CR47","first-page":"741","volume":"113","author":"J K\u00f6berlein-Neu","year":"2016","unstructured":"K\u00f6berlein-Neu J, Mennemann H, Hamacher S, Waltering I, Jaehde U, Schaffert C, et al. Interprofessional medication management in patients with multiple morbidities. Dtsch Arztebl Int. 2016;113(44):741\u20138.","journal-title":"Dtsch Arztebl Int"}],"container-title":["Journal of Pharmaceutical Health Care and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40780-025-00422-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40780-025-00422-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40780-025-00422-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T16:29:52Z","timestamp":1741019392000},"score":1,"resource":{"primary":{"URL":"https:\/\/jphcs.biomedcentral.com\/articles\/10.1186\/s40780-025-00422-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,3]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["422"],"URL":"https:\/\/doi.org\/10.1186\/s40780-025-00422-9","relation":{},"ISSN":["2055-0294"],"issn-type":[{"value":"2055-0294","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,3]]},"assertion":[{"value":"18 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval for conducting the study was granted from the Ethics Committee of the Medical Faculty of the University of Rostock as well as the Ethics Committee of the Westphalia-Lippe Medical Association and the Westphalian Wilhelms University of M\u00fcnster (Ethics ID 2020-497-b-S, approval 25th July 2020). The study was carried out in accordance with the institutional research committee\u2019s ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All patients provided written informed consent for participation and scientific data analysis prior to the commencement of their care at the Bundeswehr Center of Sports Medicine.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent obtained for research"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16"}}