{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T01:54:11Z","timestamp":1756000451965,"version":"3.41.2"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"JSPS KAKENHI","award":["24K23735"],"award-info":[{"award-number":["24K23735"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Pharm Health Care Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Hyponatremia is an electrolyte abnormality that is often caused by the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and frequently encountered in the field of oncology. Although SIADH is a known complication of certain chemotherapeutic agents, its occurrence with oxaliplatin is rare. We report a case of SIADH in a patient with colon cancer who was undergoing treatment comprising capecitabine and oxaliplatin (CAPOX) plus bevacizumab.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>A 70-year-old man with stage cT4bN2M0 colon cancer underwent chemotherapy with CAPOX plus bevacizumab. On day 7 of treatment, the patient developed severe hyponatremia (serum sodium level, 108 mmol\/L) accompanied by nausea and ileus. Laboratory test results were consistent with SIADH, including low serum osmolality, elevated urine osmolality, elevated sodium concentration, and elevated antidiuretic hormone levels. The condition improved with 3% saline infusion and fluid restriction. No other underlying causes, such as central nervous system lesions or adrenal or thyroid dysfunction, were identified. CAPOX-induced SIADH was diagnosed based on clinical findings and the exclusion of other etiologies. Transition to second-line therapy was performed without SIADH recurrence.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Oxaliplatin-based regimens may rarely induce SIADH. Clinicians should be vigilant of electrolyte disturbances during chemotherapy and promptly manage hyponatremia to avoid severe complications.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s40780-025-00476-9","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T03:30:34Z","timestamp":1753932634000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Syndrome of inappropriate antidiuretic hormone secretion in a patient with colon cancer using CAPOX plus bevacizumab therapy: a case report"],"prefix":"10.1186","volume":"11","author":[{"given":"Masanobu","family":"Uchiyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daibo","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoyasu","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Yamashina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Imakyure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"476_CR1","doi-asserted-by":"publisher","unstructured":"Palmer BF, Gates JR, Lader M. Causes and management of hyponatremia. Ann Pharmacother. 2003; 37: 1694\u2013702. Available from: https:\/\/doi.org\/10.1345\/aph.1D105","DOI":"10.1345\/aph.1D105"},{"key":"476_CR2","doi-asserted-by":"publisher","unstructured":"Onitilo AA, Kio E, Doi SA. Tumor-related hyponatremia. Clin Med Res. 2007; 5: 228\u201337. Available from: https:\/\/doi.org\/10.3121\/cmr.2007.762","DOI":"10.3121\/cmr.2007.762"},{"key":"476_CR3","doi-asserted-by":"publisher","unstructured":"Raftopoulos H. Diagnosis and management of hyponatremia in cancer patients. Support Care Cancer. 2007; 15: 1341\u20137. Available from: https:\/\/doi.org\/10.1007\/s00520-007-0309-9","DOI":"10.1007\/s00520-007-0309-9"},{"key":"476_CR4","doi-asserted-by":"publisher","unstructured":"Berghmans T. Hyponatremia related to medical anticancer treatment. Support Care Cancer. 1996; 4: 341\u2013350. Available from: https:\/\/doi.org\/10.1007\/BF01788840","DOI":"10.1007\/BF01788840"},{"key":"476_CR5","doi-asserted-by":"publisher","unstructured":"Iyer AV, Krasnow SH, Dufour DR, Arcenas AS. Sodium-wasting nephropathy caused by cisplatin in a patient with small-cell lung cancer. Clin. Lung Cancer. 2003, 5, 187\u20139. Available from: https:\/\/doi.org\/10.3816\/CLC.2003.n.033","DOI":"10.3816\/CLC.2003.n.033"},{"key":"476_CR6","doi-asserted-by":"publisher","unstructured":"Daugaard G, Abildgaard U, Holstein-Rathlou NH, Bruunshuus I, Bucher D, Leyssac PP. Renal tubular function in patients treated with high-dose cisplatin. Clin Pharmacol Ther. 1988; 44, 164\u201372. Available from: https:\/\/doi.org\/10.1038\/clpt.1988.132","DOI":"10.1038\/clpt.1988.132"},{"key":"476_CR7","first-page":"2467","volume":"42","author":"Y Goto","year":"2015","unstructured":"Goto Y, Wakita S, Yoshimitsu M, Inagaki S, Kobayashi T, Kaneko S. Onset of syndrome of inappropriate secretion of antidiuretic hormone in a gastric cancer patient on SOX treatment. Gan Kagaku Ryoho. 2015;42:2467\u201370. [in Japanese].","journal-title":"Gan Kagaku Ryoho"},{"key":"476_CR8","doi-asserted-by":"publisher","unstructured":"Berghmans T, Paemans M, Body JJ. A prospective study on hyponatraemia in medical cancer patients: Epidemiology, aetiology and differential diagnosis. Support Care Cancer. 2000; 8: 192\u20137. Available from: https:\/\/doi.org\/10.1007\/s005200050284","DOI":"10.1007\/s005200050284"},{"key":"476_CR9","first-page":"18","volume":"95","author":"The Japan Endocrine Society","year":"2019","unstructured":"The Japan Endocrine Society. Diagnosis and treatment of hypothalamo-pituitary dysfunction, 2018 edition. Nihon Naibunpitsu Gakkai Zasshi (Journal Japan Endocr Society). 2019;95:18\u201320. [in Japanese].","journal-title":"Nihon Naibunpitsu Gakkai Zasshi (Journal Japan Endocr Society)"},{"key":"476_CR10","doi-asserted-by":"publisher","unstructured":"Kurtzberg J, Dennis VW, Kinney TR. Cisplatinum-induced renal salt wasting. Med Pediatr Oncol. 1984; 12: 150\u20134. Available from: https:\/\/doi.org\/10.1002\/mpo.2950120219","DOI":"10.1002\/mpo.2950120219"},{"key":"476_CR11","doi-asserted-by":"publisher","unstructured":"Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981; 30: 239\u201345. Available from: https:\/\/doi.org\/10.1038\/clpt.1981.154","DOI":"10.1038\/clpt.1981.154"},{"key":"476_CR12","doi-asserted-by":"publisher","unstructured":"Futai R, Yoshie T, Sanuki T, Inoue Y, Abe T, Sasaki A et al. Folinic acid, fluorouracil, and oxaliplatin therapy for recurrent esophageal cancer with syndrome of inadequate antidiuretic hormone secretion (SIADH) after preoperative cisplatin\/5-fluorouracil therapy. Am J Case Rep. 2022; 23: e935121. Available from: https:\/\/doi.org\/10.12659\/AJCR.935121","DOI":"10.12659\/AJCR.935121"}],"container-title":["Journal of Pharmaceutical Health Care and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40780-025-00476-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40780-025-00476-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40780-025-00476-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T03:30:35Z","timestamp":1753932635000},"score":1,"resource":{"primary":{"URL":"https:\/\/jphcs.biomedcentral.com\/articles\/10.1186\/s40780-025-00476-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["476"],"URL":"https:\/\/doi.org\/10.1186\/s40780-025-00476-9","relation":{},"ISSN":["2055-0294"],"issn-type":[{"type":"electronic","value":"2055-0294"}],"subject":[],"published":{"date-parts":[[2025,7,31]]},"assertion":[{"value":"21 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was waived for this case report as it does not meet the criteria for human subject research requiring Institutional Review Board of Fukuoka University Chikushi Hospital review.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent for the publication of this case report was obtained from the patient\u2019s wife as a representative because the patient was no longer alive at the time of submission to this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"63"}}