{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:42:56Z","timestamp":1787020976143,"version":"build-2736575974"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Pharm Health Care Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Constipation is frequently observed in patients with chronic heart failure and has been linked to a heightened risk of adverse heart failure outcomes. Although laxatives are commonly prescribed, the optimal choice for individuals with heart failure remains uncertain. We evaluated the association between magnesium oxide use and heart failure prognosis in patients with chronic heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective observational study was conducted on patients admitted to our hospital for heart failure between January 2020 and December 2023 who were continued to be prescribed the same laxatives after discharge. Patients who received magnesium oxide for regular use were categorized into the magnesium oxide group, while all other patients comprised the nonmagnesium oxide group. The primary endpoints were heart failure-related readmission and all-cause mortality, while the secondary endpoint was a composite of both. Propensity scores were calculated based on baseline patient characteristics and used to perform 1:1 nearest-neighbor matching.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the study period, 171 outpatients with heart failure were prescribed laxatives after hospital discharge, with 74 patients included in the magnesium oxide group. Using propensity score matching, a cohort of 41 matched pairs was established. After matching, the analysis showed that the hazard ratio (HR) for first readmission within 360 d was 0.33 (95% confidence interval [CI]: 0.10\u20130.92,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035). Additionally, the combined risk of first readmission and all-cause mortality was associated with an HR of 0.30 (95% CI: 0.11\u20130.82,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Magnesium oxide was strongly associated with a lower risk of readmission and\/or death in patients with heart failure who were prescribed laxatives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>N\/A. Cases were registered retrospectively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40780-025-00478-7","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T03:00:36Z","timestamp":1754622036000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between magnesium oxide use and readmission risk in patients with heart failure and constipation"],"prefix":"10.1186","volume":"11","author":[{"given":"Junichi","family":"Terashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kambara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eisei","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risako","family":"Koketsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruhiro","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Osanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Tachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"issue":"3","key":"478_CR1","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1111\/jch.13489","volume":"21","author":"Y Ishiyama","year":"2019","unstructured":"Ishiyama Y, Hoshide S, Mizuno H, Kario K. Constipation-induced pressor effects as triggers for cardiovascular events. J Clin Hypertens. 2019;21(3):421\u20135. https:\/\/doi.org\/10.1111\/jch.13489.","journal-title":"J Clin Hypertens"},{"key":"478_CR2","unstructured":"The Japanese Circulation Society, Japanese Heart Failure Society. JCS 2017\/JHFS 2017 guideline on diagnosis and treatment of acute and chronic heart failure. Available at: https:\/\/www.j-circ.or.jp\/cms\/wp-content\/uploads\/2017\/06\/JCS2017_tsutsui_h.pdf (Accessed: 28 February 2025)."},{"key":"478_CR3","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1002\/ejhf.2333","volume":"42","author":"TA McDonagh","year":"2021","unstructured":"McDonagh TA, Metra M, Adamo M, Garener RS, Baumbach A, B\u00f6hm M, et al. 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42:3599\u2013726. https:\/\/doi.org\/10.1002\/ejhf.2333.","journal-title":"Eur Heart J"},{"issue":"18","key":"478_CR4","doi-asserted-by":"publisher","first-page":"e895","DOI":"10.1161\/CIR.0000000000001063","volume":"145","author":"PA Heidenreich","year":"2022","unstructured":"Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, et al. 2022 AHA\/ACC\/HFSA guideline for the management of heart failure. Circulation. 2022;145(18):e895\u20131032. https:\/\/doi.org\/10.1161\/CIR.0000000000001063.","journal-title":"Circulation"},{"issue":"9","key":"478_CR5","doi-asserted-by":"publisher","first-page":"e037080","DOI":"10.1136\/bmjopen-2020-037080","volume":"10","author":"J Sundb\u00f8ll","year":"2020","unstructured":"Sundb\u00f8ll J, Sz\u00e9pligeti SK, Adelborg K, Szentk\u00fati P, Gregersen H, S\u00f8rensen HT. Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study. BMJ Open. 2020;10(9):e037080. https:\/\/doi.org\/10.1136\/bmjopen-2020-037080.","journal-title":"BMJ Open"},{"key":"478_CR6","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1002\/ehf2.14650","volume":"11","author":"S Namiuchi","year":"2024","unstructured":"Namiuchi S, Tanita A, Sunamura S, Onodera K, Ogata T, Noda K, et al. Effect of constipation on readmission for heart failure in patients with acute heart failure. ESC Heart Fail. 2024;11:819\u201325. https:\/\/doi.org\/10.1002\/ehf2.14650.","journal-title":"ESC Heart Fail"},{"issue":"11","key":"478_CR7","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1253\/circrep.CR-24-0060","volume":"6","author":"T Isogai","year":"2024","unstructured":"Isogai T, Morita K, Okada A, Michihata N, Matsui H, Miyawaki A, et al. Association between coexisting constipation and heart failure readmission in patients with heart failure: A nationwide database study. 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Antioxid (Basel). 2020;9(10):907. https:\/\/doi.org\/10.3390\/antiox9100907.","journal-title":"Antioxid (Basel)"}],"container-title":["Journal of Pharmaceutical Health Care and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40780-025-00478-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40780-025-00478-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40780-025-00478-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T15:02:53Z","timestamp":1754665373000},"score":1,"resource":{"primary":{"URL":"https:\/\/jphcs.biomedcentral.com\/articles\/10.1186\/s40780-025-00478-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["478"],"URL":"https:\/\/doi.org\/10.1186\/s40780-025-00478-7","relation":{},"ISSN":["2055-0294"],"issn-type":[{"value":"2055-0294","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,8]]},"assertion":[{"value":"18 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study conformed to the principles outlined in the Declaration of Helsinki and was approved by the Tosei General Hospital Medical Ethics Committee (approval number: 1292). Comprehensive informed consent was obtained from the participants by displaying an opt-out option on our website.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"68"}}