{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:32:44Z","timestamp":1772166764557,"version":"3.50.1"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Pharm Health Care Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite the increasing emphasis on safe prescribing, the impact of local formularies on physician behavior remains underexplored in community healthcare settings. To promote safer pharmacological practices, our institution implemented a hospital-originated sleep-medication formulary in January 2022, which was subsequently disseminated to other local medical institutions in early 2023. This study assessed physicians\u2019 awareness of this sleep-medication formulary, and its influence on prescribing behavior in local community healthcare settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A questionnaire survey was distributed via a regional medical-cooperation newsletter and responses were received from 84 physicians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 84 physicians, 18% were aware of the formulary. Physicians in the awareness group were more likely to prescribe the recommended medications, particularly orexin receptor antagonists, and reported significantly less difficulty in initiating hypnotic therapy. Logistic regression analysis revealed a significant association between formulary awareness and reduced difficulty in prescribing a suitable hypnotic (odds ratio: 0.24; 95% CI: 0.073\u20130.78).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Local formularies may serve as valuable tools in clinical decision-making and promote safer and more consistent prescribing practices. Strategies such as physician education, concise formulary reference sheets or physician-oriented pocket references, and the development of patient-friendly information materials are warranted to support broader implementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>Not applicable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40780-025-00521-7","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T15:46:28Z","timestamp":1765208788000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A survey on the awareness of a sleep-medication formulary in community health care and its influence on prescribing behavior"],"prefix":"10.1186","volume":"12","author":[{"given":"Akira","family":"Ishikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Mizumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Utsunomiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moriyuki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Shiko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiko","family":"Osawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Makabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"521_CR1","doi-asserted-by":"publisher","unstructured":"Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV. Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep. 2004;27(7):1255\u20131273. https:\/\/doi.org\/10.1093\/sleep\/27.7.1255. PMID: 15586779.","DOI":"10.1093\/sleep\/27.7.1255"},{"key":"521_CR2","doi-asserted-by":"publisher","unstructured":"The 2023 American Geriatrics Society Beers Criteria\u00ae Update Expert Panel. American Geriatrics Society 2023 updated AGS Beers Criteria\u00ae for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2023;71(7):2052\u20132081. PMID: 37139824. https:\/\/doi.org\/10.1111\/jgs.18372.","DOI":"10.1111\/jgs.18372"},{"key":"521_CR3","doi-asserted-by":"publisher","first-page":"469580221087876","DOI":"10.1177\/00469580221087876","volume":"59","author":"N Kanai","year":"2022","unstructured":"Kanai N, Ando M, Shimodate M, Miyazaki Y, Saito T. Influence of hospital formularies on outpatient prescribing practices: a single-center, 2-year follow-up, retrospective cohort study of a local formulary in Japan. Inquiry. 2022;59:469580221087876. https:\/\/doi.org\/10.1177\/00469580221087876.","journal-title":"Inquiry"},{"key":"521_CR4","unstructured":"Ministry of Health, Labour and Welfare. FY2022 MHLW special research project operation of formulary. Accessed 1 Jun 2025. https:\/\/www.mhlw.go.jp\/stf\/seisakunitsuite\/bunya\/0000188411.html."},{"key":"521_CR5","unstructured":"Ministry of Health, Labour and Welfare. FY2020 MHLW special research project survey of physicians\u2019 attitudes toward regional formulary. Accessed 1 Jun 2025. https:\/\/mhlw-grants.niph.go.jp\/system\/files\/report_pdf\/202006020A-buntan2_1.pdf."},{"issue":"1","key":"521_CR6","first-page":"113","volume":"38","author":"R Mizumura","year":"2023","unstructured":"Mizumura R, Ishikawa A, Ito M, et al. Creation and operation methods of the formulary system for sleeping pills at Saitama medical university hospital. Japanese J Psychiatric Treat. 2023;38(1):113\u201320.","journal-title":"Japanese J Psychiatric Treat"},{"key":"521_CR7","doi-asserted-by":"publisher","first-page":"1071962","DOI":"10.3389\/fpsyt.2023.1071962","volume":"14","author":"M Takeshima","year":"2023","unstructured":"Takeshima M, Aoki Y, Ie K, Katsumoto E, Tsuru E, Tsuboi T, et al. Physicians\u2019 attitudes toward hypnotics for insomnia: a questionnaire-based study. Front Psychiatry. 2023;14:1071962. https:\/\/doi.org\/10.3389\/fpsyt.2023.1071962.","journal-title":"Front Psychiatry"},{"key":"521_CR8","doi-asserted-by":"publisher","unstructured":"Muehlan C, Roch C, Vaillant C, Dingemanse J. The orexin story and orexin receptor antagonists for the treatment of insomnia. J Sleep Res. 2023;32(6):e13902. https:\/\/doi.org\/10.1111\/jsr.13902. PMID: 37086045.","DOI":"10.1111\/jsr.13902"},{"key":"521_CR9","doi-asserted-by":"publisher","unstructured":"Pan G, Ni L, Yan H, Yao L. Association between the use of orexin receptor antagonists and falls or fractures: a meta-analysis. J Psychiatr Res. 2024;176:393\u2013402. https:\/\/doi.org\/10.1016\/j.jpsychires.2024.06.029. PMID: 38944018.","DOI":"10.1016\/j.jpsychires.2024.06.029"}],"container-title":["Journal of Pharmaceutical Health Care and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40780-025-00521-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40780-025-00521-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40780-025-00521-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:04:38Z","timestamp":1768341878000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s40780-025-00521-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["521"],"URL":"https:\/\/doi.org\/10.1186\/s40780-025-00521-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7218662\/v1","asserted-by":"object"}]},"ISSN":["2055-0294"],"issn-type":[{"value":"2055-0294","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"26 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Review Committee of Saitama Medical University (Approval No.: 2023-027). All respondents received detailed information about the study\u2019s purpose, procedures, and confidentiality safeguards. Informed consent was obtained through written agreement or electronic confirmation via an online form in accordance with the ethical research guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"K.M. has received honoraria from Viatris, Mitsubishi Tanabe Pharma, Janssen Pharma, Otsuka Pharmaceutical, Sumitomo Pharma, Takeda Pharmaceutical, Lundbeck Japan, and Eisai, and research donations from Eisai. The other authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3"}}