{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:07:13Z","timestamp":1781626033321,"version":"3.54.5"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Pharm Health Care Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Opioids are commonly used for postoperative analgesia after arthroscopic rotator cuff repair; however, they pose an increased risk of postoperative nausea and vomiting. Therefore, multimodal analgesia using non-opioid analgesics is recommended. However, the efficacy of postoperative opioid-free analgesia, including acetaminophen, has not been fully elucidated. Therefore, this study aimed to assess the effect of postoperative opioid-free, acetaminophen-containing analgesia on postoperative outcomes in patients undergoing arthroscopic rotator cuff repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent arthroscopic rotator cuff repair at Rakuwakai Marutamachi Hospital between June 2022 and May 2025 were included. The patients were divided into postoperative opioid and opioid-free groups. Propensity score matching was used to balance baseline characteristics. The postoperative outcomes, including pain scores, incidence of nausea and vomiting, use of additional analgesics, and length of postoperative hospital stay, were compared between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After propensity score matching, 78 patients were assigned to each group. Postoperative pain scores did not significantly differ between the groups. However, the postoperative opioid-free group had a significantly lower incidence of nausea and vomiting (5.1% vs. 20.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and use of additional analgesics (5.1% vs. 20.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The length of postoperative hospital stay did not differ significantly between the groups (13\u2009days vs. 11.5\u2009days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.268).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Postoperative opioid-free analgesia, including acetaminophen, may provide pain control comparable to conventional opioid-based strategies, reduce the incidence of postoperative nausea and vomiting, and represent a safe and effective approach for postoperative analgesia after arthroscopic rotator cuff repair.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40780-025-00530-6","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:23:59Z","timestamp":1766399039000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postoperative opioid-free analgesia with acetaminophen and its impact on pain and postoperative nausea and vomiting following arthroscopic rotator cuff repair: a single-center retrospective study"],"prefix":"10.1186","volume":"11","author":[{"given":"Misa","family":"Okizuka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Inose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Maruoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiko","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subaru","family":"Hirotsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Muraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"530_CR1","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.jor.2021.03.009","volume":"24","author":"S Sakha","year":"2021","unstructured":"Sakha S, Seaher S, et al. Update on all-arthroscopic versus mini-open rotator cuff repair: a systematic review and meta-analysis. J Orthop. 2021;24:254\u201363. https:\/\/doi.org\/10.1016\/j.jor.2021.03.009.","journal-title":"J Orthop"},{"issue":"2","key":"530_CR2","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s43465-020-00345-7","volume":"55","author":"KD Mohammed","year":"2021","unstructured":"Mohammed KD, et al. The relevance of open rotator cuff repair in 2021. Indian J Orthop. 2021;55(2):433\u201342. https:\/\/doi.org\/10.1007\/s43465-020-00345-7.","journal-title":"Indian J Orthop"},{"issue":"10","key":"530_CR3","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1111\/anae.14796","volume":"74","author":"O Toma","year":"2019","unstructured":"Toma O, Persoons B, Pogatzki-Zahn E, Van de Velde M, Joshi GP. PROSPECT working group collaborators. PROSPECT guideline for rotator cuff repair surgery: systematic review and procedure-specific postoperative pain management recommendations. 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The requirement for informed consent was waived by the institutional review board and information was disclosed on the hospital website in an opt-out format.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Individual consent for publication was not required because this study did not contain any personally identifiable information.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"RI received funding for the commissioned research from Kowa Company, Ltd. However, this study was not directly funded. YM received grants from Pfizer Japan Inc.; Kowa Company Ltd.; the Japan Pharmaceutical Association; the Japan Society for the Promotion of Science; and the Ministry of Health, Labour and Welfare. YM is also a board member of the Japanese Society of Pharmaceutical Health Care and Sciences and the Japanese Society for Infection Prevention and Control, and a committee member of the AMR Clinical Reference Center. However, this study was not directly funded. The other authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"115"}}