{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:26:39Z","timestamp":1786926399096,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":69,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Pharm Health Care Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adolescents and young adults (AYAs) with cancer often face developmental stage\u2013specific challenges related to education and employment, interpersonal relationships, fertility, and family formation. Psychosocial support is important in cancer care, especially since psychological distress and anxiety tend to increase immediately after diagnosis. Some patients have an established relationship with a community pharmacist before diagnosis, but it remains unclear whether such continuity is associated with patient-reported satisfaction with pharmacist consultations during the early post-diagnosis period. Using nationwide survey data, this study investigated the association between patient-reported satisfaction at the first community pharmacy visit after an initial cancer diagnosis, assessed using the Medical Interview Satisfaction Scale Japanese version (MISS-21J), and pre-diagnosis pharmacist continuity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A nationwide cross-sectional online survey was conducted from March 25 to 27, 2025. Data were analyzed for 407 patients with an initial cancer diagnosis who were diagnosed at age 15\u201339 years and visited a community pharmacy after diagnosis. Participants were grouped according to the presence or absence of pre-diagnosis pharmacist continuity. The prespecified primary outcomes were the MISS-21J distress relief and rapport subscale scores, which reflect domains of patient-reported satisfaction with pharmacist consultations. Multivariable linear regression models (ordinary least squares) were fitted, adjusting for age at diagnosis, sex, cancer type, residential area, parents available, partner status, and minor children. Adjusted means (least-squares means; LSMeans) and adjusted mean differences with 95% confidence intervals (CIs) were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      For distress relief, the adjusted mean was 5.33 in patients with pre-diagnosis pharmacist continuity and 4.72 in those without such continuity (adjusted mean difference: 0.61; 95% CI, 0.42\u20130.81;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). For rapport, the adjusted mean was 5.20 in patients with pre-diagnosis pharmacist continuity and 4.60 in those without such continuity (adjusted mean difference: 0.60; 95% CI, 0.41\u20130.80;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among AYAs newly diagnosed with cancer, pre-diagnosis pharmacist continuity was associated with higher patient-reported satisfaction with pharmacist consultations, particularly in the MISS-21J domains of distress relief and rapport. These findings highlight the potential value of accessible, continuous relationships with pharmacists in improving patients\u2019 perceived pharmaceutical care experience during the early post-diagnosis period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40780-026-00589-9","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:16:24Z","timestamp":1781018184000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship of pre-diagnosis pharmacist continuity with patient-reported satisfaction at the first post-diagnosis community pharmacy visit among adolescents and young adults with cancer: a nationwide cross-sectional online survey"],"prefix":"10.1186","volume":"12","author":[{"given":"Atsunobu","family":"Sagara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomofumi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Terakado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"589_CR1","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1089\/jayao.2022.0130","volume":"12","author":"K Neylon","year":"2023","unstructured":"Neylon K, Condren C, Guerin S, Looney K. What Are the Psychosocial Needs of Adolescents and Young Adults with Cancer? A Systematic Review of the Literature. J Adolesc Young Adult Oncol. 2023;12:799\u2013820.","journal-title":"J Adolesc Young Adult Oncol"},{"key":"589_CR2","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1002\/cncr.22107","volume":"107","author":"EE Evan","year":"2006","unstructured":"Evan EE, Zeltzer LK. Psychosocial dimensions of cancer in adolescents and young adults. Cancer. 2006;107:1663\u201371.","journal-title":"Cancer"},{"key":"589_CR3","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1007\/s11764-016-0527-6","volume":"10","author":"M Barnett","year":"2016","unstructured":"Barnett M, McDonnell G, DeRosa A, Schuler T, Philip E, Peterson L, et al. Psychosocial outcomes and interventions among cancer survivors diagnosed during adolescence and young adulthood (AYA): a systematic review. J Cancer Surviv. 2016;10:814\u201331.","journal-title":"J Cancer Surviv"},{"key":"589_CR4","doi-asserted-by":"publisher","first-page":"e27486","DOI":"10.1002\/pbc.27486","volume":"66","author":"AW Smith","year":"2019","unstructured":"Smith AW, Keegan T, Hamilton A, Lynch C, Wu XC, Schwartz SM, et al. Understanding care and outcomes in adolescents and young adult with Cancer: A review of the AYA HOPE study. Pediatr Blood Cancer. 2019;66:e27486.","journal-title":"Pediatr Blood Cancer"},{"key":"589_CR5","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1002\/cncr.26043","volume":"117","author":"NM D\u2019Agostino","year":"2011","unstructured":"D\u2019Agostino NM, Penney A, Zebrack B. Providing developmentally appropriate psychosocial care to adolescent and young adult cancer survivors. Cancer. 2011;117:2329\u201334.","journal-title":"Cancer"},{"key":"589_CR6","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s10147-021-02064-x","volume":"27","author":"K Nakata","year":"2022","unstructured":"Nakata K, Hiyama E, Katanoda K, Matsuda T, Tada Y, Inoue M, et al. Cancer in adolescents and young adults in Japan: epidemiology and cancer strategy. Int J Clin Oncol. 2022;27:7\u201315.","journal-title":"Int J Clin Oncol"},{"key":"589_CR7","doi-asserted-by":"publisher","first-page":"44","DOI":"10.31662\/jmaj.2021-0106","volume":"5","author":"H Ishiki","year":"2022","unstructured":"Ishiki H, Hirayama T, Horiguchi S, Iida I, Kurimoto T, Asanabe M, et al. A Support System for Adolescent and Young Adult Patients with Cancer at a Comprehensive Cancer Center. Jma j. 2022;5:44\u201354.","journal-title":"Jma j"},{"key":"589_CR8","doi-asserted-by":"crossref","unstructured":"Ko\u0161ir U, Totovina A, Stark D, Ferrari A, de Munter J, van der Graaf WTA, et al. Minimum standards of specialist adolescent and young adult (AYA) cancer care units: recommendations and implementation roadmap. ESMO Open. 2025;10.","DOI":"10.1016\/j.esmoop.2025.105829"},{"key":"589_CR9","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.6004\/jnccn.2012.0117","volume":"10","author":"PF Coccia","year":"2012","unstructured":"Coccia PF, Altman J, Bhatia S, Borinstein SC, Flynn J, George S, et al. Adolescent and young adult oncology. Clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2012;10:1112\u201350.","journal-title":"J Natl Compr Canc Netw"},{"key":"589_CR10","doi-asserted-by":"publisher","first-page":"100672","DOI":"10.1016\/j.apjon.2025.100672","volume":"12","author":"JY Lee","year":"2025","unstructured":"Lee JY, Hong S. Psychological distress in newly diagnosed patients with gastrointestinal cancer: A scoping review. Asia Pac J Oncol Nurs. 2025;12:100672.","journal-title":"Asia Pac J Oncol Nurs"},{"key":"589_CR11","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1097\/01.NCC.0000305744.64452.fe","volume":"31","author":"MN Liao","year":"2008","unstructured":"Liao MN, Chen MF, Chen SC, Chen PL. Uncertainty and anxiety during the diagnostic period for women with suspected breast cancer. Cancer Nurs. 2008;31:274\u201383.","journal-title":"Cancer Nurs"},{"key":"589_CR12","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1089\/jayao.2020.0027","volume":"10","author":"LR Holland","year":"2021","unstructured":"Holland LR, Walker R, Henney R, Cashion CE, Bradford NK. Adolescents and Young Adults with Cancer: Barriers in Access to Psychosocial Support. J Adolesc Young Adult Oncol. 2021;10:46\u201355.","journal-title":"J Adolesc Young Adult Oncol"},{"key":"589_CR13","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1089\/jayao.2016.0012","volume":"6","author":"H Bibby","year":"2017","unstructured":"Bibby H, White V, Thompson K, Anazodo A. What Are the Unmet Needs and Care Experiences of Adolescents and Young Adults with Cancer? A Systematic Review. J Adolesc Young Adult Oncol. 2017;6:6\u201330.","journal-title":"J Adolesc Young Adult Oncol"},{"key":"589_CR14","doi-asserted-by":"crossref","unstructured":"Egbewande OM, Abdulwasiu MA, Yusuf RO, Durojaye AB, Ashimiyu-Abdulsalam ZI. Roles of community pharmacists in cancer management. Innov Pharm. 2022;13.","DOI":"10.24926\/iip.v13i3.4946"},{"key":"589_CR15","unstructured":"Ministry of Health, Labour and Welfare. A vision of pharmacies for patients. 2015. http:\/\/www.hap-fw.org\/oathas\/pdf\/20151023_vision.pdf. Accessed 17 May 2026."},{"key":"589_CR16","doi-asserted-by":"publisher","first-page":"453","DOI":"10.5649\/jjphcs.47.453","volume":"47","author":"R Iketani","year":"2021","unstructured":"Iketani R, Konomura K. Utility of the Family Pharmacist System: a Retrospective Cohort Study Using Administrative Claims Data. Japanese J Pharm health care Sci. 2021;47:453\u201363.","journal-title":"Japanese J Pharm health care Sci"},{"key":"589_CR17","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1186\/s12913-022-08093-0","volume":"22","author":"R Iketani","year":"2022","unstructured":"Iketani R, Konomura K. Identification of individuals benefiting from the kakaritsuke-yakuzaishi (family pharmacist) system in Japan: a retrospective cohort study using an employment-based health insurance claims database. BMC Health Serv Res. 2022;22:682.","journal-title":"BMC Health Serv Res"},{"key":"589_CR18","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1093\/fampra\/19.3.257","volume":"19","author":"R Meakin","year":"2002","unstructured":"Meakin R, Weinman J. The \u2018Medical Interview Satisfaction Scale\u2019 (MISS-21) adapted for British general practice. Fam Pract. 2002;19:257\u201363.","journal-title":"Fam Pract"},{"key":"589_CR19","first-page":"24","volume":"11","author":"M Hanya","year":"2013","unstructured":"Hanya M, Sakurai M, Yoshioka Y, Murata A, Kamei H. Development and validity testing of a Japanese version of MISS-21 for evaluating patient satisfaction with patient education regarding taking OTC medication. J Pharm communication. 2013;11:24\u201332.","journal-title":"J Pharm communication"},{"key":"589_CR20","first-page":"16","volume":"20","author":"A Ikeshita","year":"2022","unstructured":"Ikeshita A, Sagara A, Azechi T, Maeda-Minami A, Sato K, Koinuma M, et al. Survey of pregnant\/postpartum women\u2019s ease of consultation with pharmacists and self-reporting their pregnant\/postpartum status. J Pharm Communication. 2022;20:16\u201329.","journal-title":"J Pharm Communication"},{"key":"589_CR21","first-page":"6","volume":"21","author":"A Ikeshita","year":"2023","unstructured":"Ikeshita A, Sagara A, Azechi T, Maeda-Minami A, Sato K, Kominato H, et al. Evaluation of the relationship between pregnant\/postpartum women\u2019s characteristics and pharmacy use experience in terms of consultation needs with pharmacists. J Pharm Communication. 2023;21:6\u201313.","journal-title":"J Pharm Communication"},{"key":"589_CR22","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s40780-025-00467-w","volume":"11","author":"T Watanabe","year":"2025","unstructured":"Watanabe T, Sagara A, Abe T, Komuro M, Yubune K, Yoshikawa S, et al. Cross-sectional survey on cancer patients\u2019 concerns and consultation needs with pharmacists at the time of initial diagnosis. J Pharm Health Care Sci. 2025;11:59.","journal-title":"J Pharm Health Care Sci"},{"key":"589_CR23","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/jgf2.70040","volume":"26","author":"C Kaneko","year":"2025","unstructured":"Kaneko C, Suzuki S, Tanaka I, Hiruma H, Okada H. Patient experience in community pharmacy services: A scoping review. J Gen Fam Med. 2025;26:514\u201322.","journal-title":"J Gen Fam Med"},{"key":"589_CR24","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1089\/jayao.2022.0087","volume":"12","author":"SE Taghavi","year":"2023","unstructured":"Taghavi SE, Williams AP, Leavitt A, Hoeft A, Hall BC. Adolescent and Young Adult Communication Preferences. J Adolesc Young Adult Oncol. 2023;12:599\u2013603.","journal-title":"J Adolesc Young Adult Oncol"},{"key":"589_CR25","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1200\/JCO.2011.39.5467","volume":"30","author":"B Zebrack","year":"2012","unstructured":"Zebrack B, Isaacson S. Psychosocial Care of Adolescent and Young Adult Patients With Cancer and Survivors. J Clin Oncol. 2012;30:1221\u20136.","journal-title":"J Clin Oncol"},{"key":"589_CR26","doi-asserted-by":"publisher","first-page":"2381104","DOI":"10.1080\/20523211.2024.2381104","volume":"17","author":"EM Manoliu-Hamwi","year":"2024","unstructured":"Manoliu-Hamwi EM, Dasc\u0103lu CG, Zegan G, C\u0103r\u0103u\u0219u EM, Ghiciuc CM, Iv\u0103nescu MC, et al. Patient\u2019s satisfaction level with community pharmacies services in Romania: a questionnaire-based study. J Pharm Policy Pract. 2024;17:2381104.","journal-title":"J Pharm Policy Pract"},{"key":"589_CR27","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1002\/cncr.29866","volume":"122","author":"EL Warner","year":"2016","unstructured":"Warner EL, Kent EE, Trevino KM, Parsons HM, Zebrack BJ, Kirchhoff AC. Social well-being among adolescents and young adults with cancer: A systematic review. Cancer. 2016;122:1029\u201337.","journal-title":"Cancer"},{"key":"589_CR28","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40780-026-00548-4","volume":"12","author":"A Sagara","year":"2026","unstructured":"Sagara A, Watanabe T, Abe T, Shimizu T, Shirozu S, Terakado H. Association of family pharmacist continuity with patient-reported satisfaction in patients with metastatic cancer: a nationwide cross-sectional study. J Pharm Health Care Sci. 2026;12:26.","journal-title":"J Pharm Health Care Sci"}],"container-title":["Journal of Pharmaceutical Health Care and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40780-026-00589-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40780-026-00589-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40780-026-00589-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:19:51Z","timestamp":1786925991000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s40780-026-00589-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["589"],"URL":"https:\/\/doi.org\/10.1186\/s40780-026-00589-9","relation":{},"ISSN":["2055-0294"],"issn-type":[{"value":"2055-0294","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]},"assertion":[{"value":"25 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was conducted in accordance with Ethical Guidelines for Medical and Health Research Involving Human Subjects in Japan. This study was approved by the Ethical Review Committee of Saitama Prefectural Cancer Center (Approval No: 2012; Date of approval: March 14, 2025). Participation was entirely voluntary, and informed consent was deemed to be obtained upon completion and submission of the questionnaire. Participants were clearly informed that all data would be anonymized to protect privacy and used solely for statistical analyses.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"73"}}