{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:28:09Z","timestamp":1793460489194,"version":"4.5.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:00:00Z","timestamp":1586476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:00:00Z","timestamp":1586476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Japan Society for the Promotion of Science Grant-in-Aid for Research Activity start-up","award":["19K23918"],"award-info":[{"award-number":["19K23918"]}]},{"name":"The Shinnihon Foundation of Advanced Medical Treatment Research"},{"DOI":"10.13039\/501100007369","name":"Fukuoka Foundation for Sound Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007369","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Intramural metastasis is rare in colorectal cancer, especially metastasis of ascending colon cancer to the appendix.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>A 64-year-old man was admitted to our hospital for surgery for ascending colon cancer detected by medical examination. Colonoscopy identified a type-2 tumor in the ascending colon, which was diagnosed as adenocarcinoma. Abdominal computed tomography revealed focal thickening of the ascending colon and middle of the appendix and swelling of the lymph nodes around the ileocolic artery. The patient underwent laparoscopic right hemi-colectomy with D3 lymph node dissection. Histopathological findings revealed that the ascending colon cancer was moderately differentiated adenocarcinoma with lymphatic and vascular invasion (stage IIIB; pT3N2M0). Additionally, moderately differentiated adenocarcinoma was observed mainly in the submucosa and muscularis propria of the appendix, which was approximately 10 cm proximal to the ascending colon cancer. These findings indicated intramural metastasis to the appendix from the ascending colon cancer. The patient experienced recurrence with lung metastasis 2.5 years after the first surgery.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Intramural metastasis of ascending colon cancer to the appendix is extremely rare. Because the risk of recurrence and the prognosis for intramural metastasis has not been clarified, careful follow-up is recommended.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s40792-020-00829-6","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T04:42:19Z","timestamp":1586493739000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Intramural metastasis to the appendix from ascending colon cancer: a case report"],"prefix":"10.1186","volume":"6","author":[{"given":"Toshiya","family":"Abe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Takesue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Sada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Kozono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Kitaura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Nishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Mine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadafumi","family":"Tamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,10]]},"reference":[{"key":"829_CR1","doi-asserted-by":"crossref","unstructured":"Takubo K, Tanaka Y, Fujita K. Prognostic significance of intramural metastasis in patients with esophageal carcinoma. 1990;1816\u20139.","DOI":"10.1002\/1097-0142(19900415)65:8<1816::AID-CNCR2820650825>3.0.CO;2-L"},{"issue":"4","key":"829_CR2","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s10120-012-0228-4","volume":"16","author":"T Hashimoto","year":"2013","unstructured":"Hashimoto T, Arai K, Yamashita Y, Iwasaki Y, Hishima T. Characteristics of intramural metastasis in gastric cancer. Gastric Cancer. 2013;16(4):537\u201342.","journal-title":"Gastric Cancer"},{"key":"829_CR3","doi-asserted-by":"publisher","unstructured":"Okamura A, Watanabe M, Kozuki R, Toihata T. Significance of intramural metastasis in patients with esophageal squamous cell carcinoma\u00a0: an indicator of aggressive cancer behavior. World J Surg [Internet]. 2019;43(8):1997\u20132005. Available from: https:\/\/doi.org\/10.1007\/s00268-019-05004-z.","DOI":"10.1007\/s00268-019-05004-z"},{"issue":"11","key":"829_CR4","first-page":"3","volume":"96","author":"Y Li","year":"2017","unstructured":"Li Y, Li M, Li X, Sang H. Metastasis to the appendix from adenocarcinoma of the ascending colon. Med (United States). 2017;96(11):3\u20136.","journal-title":"Med (United States)"},{"issue":"2","key":"829_CR5","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1245\/ASO.2003.05.027","volume":"10","author":"T Nakagoe","year":"2003","unstructured":"Nakagoe T, Yamaguchi EI, Tanaka K, Sawai T, Tsuji T, Shibasaki SI, et al. Distal intramural spread is an independent prognostic factor for distant metastasis and poor outcome in patients with rectal cancer: a multivariate analysis. Ann Surg Oncol. 2003;10(2):163\u201370.","journal-title":"Ann Surg Oncol"},{"issue":"22","key":"829_CR6","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1200\/JCO.18.02059","volume":"37","author":"H Ueno","year":"2019","unstructured":"Ueno H, Ishiguro M, Nakatani E, Ishikawa T, Uetake H. Prospective multicenter study on the prognostic and predictive impact of tumor budding in stage II colon cancer\u00a0: results from the SACURA Trial abstract. J Clin Oncol. 2019;37(22):1886\u201394.","journal-title":"J Clin Oncol"},{"issue":"18","key":"829_CR7","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1200\/JCO.2010.33.7725","volume":"29","author":"H Ueno","year":"2011","unstructured":"Ueno H, Mochizuki H, Shirouzu K, Kusumi T, Yamada K, Ikegami M, et al. Actual status of distribution and prognostic impact of extramural discontinuous cancer spread in colorectal cancer. J Clin Oncol. 2011;29(18):2550\u20136.","journal-title":"J Clin Oncol"},{"issue":"2","key":"829_CR8","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1007\/s00423-003-0453-8","volume":"389","author":"N Yuasa","year":"2004","unstructured":"Yuasa N, Miyake H, Yamada T, Oda K, Nimura Y, Nagasaka T, et al. Prognostic significance of the location of intramural metastasis in patients with esophageal squamous cell carcinoma. Langenbeck\u2019s Arch Surg. 2004;389(2):122\u20137.","journal-title":"Langenbeck\u2019s Arch Surg"},{"key":"829_CR9","doi-asserted-by":"publisher","unstructured":"Moon DH, Jeon JH, Yang HC, Kim Y Il, Lee JY, Kim MS, et al. Intramural metastasis as a risk factor for recurrence in esophageal squamous cell carcinoma. Ann Thorac Surg [Internet]. 2018;106(1):249\u2013256. Available from: https:\/\/doi.org\/10.1016\/j.athoracsur.2018.02.018.","DOI":"10.1016\/j.athoracsur.2018.02.018"},{"key":"829_CR10","doi-asserted-by":"crossref","unstructured":"Topham C, Zaninelli M, Clingan P, Bridgewater J, Tabah-fisch I. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. 2004;2343\u201351.","DOI":"10.1056\/NEJMoa032709"},{"key":"829_CR11","doi-asserted-by":"publisher","unstructured":"Schmoll HJ, Cutsem E Van, Stein A, Valentini V, Glimelius B, Haustermans K, et al. ESMO Consensus Guidelines for management of patients with colon and rectal cancer . A personalized approach to clinical decision making. Ann Oncol [Internet]. 2012;23(10):2479\u20132516. Available from: https:\/\/doi.org\/10.1093\/annonc\/mds236.","DOI":"10.1093\/annonc\/mds236"}],"updated-by":[{"DOI":"10.1186\/s40792-020-00844-7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000}}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-020-00829-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40792-020-00829-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-020-00829-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T23:05:59Z","timestamp":1618009559000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-020-00829-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,10]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["829"],"URL":"https:\/\/doi.org\/10.1186\/s40792-020-00829-6","relation":{"correction":[{"id-type":"doi","id":"10.1186\/s40792-020-00844-7","asserted-by":"object"}]},"ISSN":["2198-7793"],"issn-type":[{"value":"2198-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,10]]},"assertion":[{"value":"17 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2020","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the original publication of this article [1], an author\u2019s name should be changed from Shin Takasue to Shin Takesue.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"69"}}