{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:49:34Z","timestamp":1791496174605,"version":"4.3.4"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T00:00:00Z","timestamp":1587859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T00:00:00Z","timestamp":1587859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Breast angiosarcoma (AS) is a rare malignant breast tumor arising from endothelial cells lining the blood vessels. The prognosis of AS is reportedly poor. However, the effectiveness of chemotherapy and radiation is still controversial. Surgery is the only curable treatment, and removal of AS with adequate surgical margin is important.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>We report two cases of primary and radiation-induced breast angiosarcoma (AS) after performing breast conserving surgery (BCS) for breast cancer. In case 1, a 72-year-old woman underwent right BCS with adjuvant radiation therapy (RT) for breast cancer 5\u2009years prior. She was diagnosed with AS of the right breast and underwent mastectomy with a wide skin resection of the breast. As the tumor cells were positive for c-myc, this tumor was diagnosed as a radiation-induced AS. In case 2, an 80-year-old woman underwent BCS without adjuvant RT. She was diagnosed with AS 3\u2009years after BCS and underwent mastectomy with a wide skin resection of the breast. The tumor was diagnosed to be a primary AS because there were no episodes of RT or lymphedema. Both cases developed local recurrence within 1 year of surgery.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Our cases suggest that surgical margin is associated with the risk of local recurrence, and the difficulty of deciding a safe surgical margin should be set during preoperative diagnosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s40792-020-00841-w","type":"journal-article","created":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T08:02:31Z","timestamp":1587888151000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Two cases of breast angiosarcoma after breast conserving surgery"],"prefix":"10.1186","volume":"6","author":[{"given":"Eriko","family":"Shiraki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yookija","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Shibayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Tsuyuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,26]]},"reference":[{"key":"841_CR1","unstructured":"Rosen P. P (2008) Rosen\u2019s breast pathology 3rd ed. Lippincott Williams & Wilkins, Philadelphia."},{"issue":"5","key":"841_CR2","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1007\/s12282-015-0630-y","volume":"23","author":"K Masai","year":"2016","unstructured":"Masai K, Kinoshita T, Jimbo K, et al. Clinicopahological features of breast angiosarcoma. Breast Cancer. 2016;23(5):718\u201323.","journal-title":"Breast Cancer"},{"key":"841_CR3","volume-title":"Rosai and Ackerman\u2019s surgical pathology","author":"J Rosai","year":"2004","unstructured":"Rosai J. Rosai and Ackerman\u2019s surgical pathology. Edinburgh: Mosby; 2004."},{"issue":"2","key":"841_CR4","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1023\/A:1005997017102","volume":"47","author":"LJ Strobbe","year":"1998","unstructured":"Strobbe LJ, Peterse HL, van Tinteren H, et al. Angiosarcoma of the breast after conservation therapy for invasive cancer. An unforseen sequela. 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BMC Cancer. 2017;17(1):295.","journal-title":"BMC Cancer"},{"issue":"4","key":"841_CR8","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1245\/s10434-012-2755-y","volume":"20","author":"KE Torres","year":"2013","unstructured":"Torres KE, Ravi V, Kin K, et al. Long-term outcomes in patients with radiation-associated angiosarcomas of the breast following surgery and radiotherapy for breast cancer. Ann Surg Oncol. 2013;20(4):1267\u201374.","journal-title":"Ann Surg Oncol"},{"issue":"8","key":"841_CR9","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1002\/cncr.11277","volume":"97","author":"AT Monroe","year":"2003","unstructured":"Monroe AT, Feigenberg SJ, Mendenhall NP. Angiosarcoma after breast-conserving therapy. 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