{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T09:20:49Z","timestamp":1772443249198,"version":"3.50.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Primary breast lymphoma is rare. Occurrence rates of malignant breast tumors in children are also quite low. We herein report a B-lymphoblastic lymphoma of the breast arisen in an adolescent girl. To the best of our knowledge, this is the youngest case with primary breast non-Hodgkin\u2019s lymphoma.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>A 14-year-old Japanese girl felt a lump in her right breast and came to our hospital. A circumscribed soft mass, 30\u2009mm in diameter, was palpable. Histological examination revealed atypical lymphoid cells diffusely spreading into the breast tissue. Based on results of immunohistochemistry and flow cytometry, her disease was diagnosed as B-lymphoblastic lymphoma (stage I). She was then referred to the pediatric department and received combination chemotherapy, based on a chemotherapy regimen for children with acute lymphoblastic leukemia. Following remission induction therapy, we confirmed no FDG uptake in the right breast on PET-CT scan.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>We have described a rare malignant lymphoma arising in the breast of an adolescent female. Histological assessment is necessary for diagnosis of breast lymphoma. However, it can be challenging with several reasons, and clinical information may contribute to the assessment. Moreover, treatments for lymphoma vary according to disease types. Thus, surgeons should collaborate closely with pathologists, pediatricians, and hematologists.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s40792-020-00850-9","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T19:03:17Z","timestamp":1588186997000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Primary breast non-Hodgkin\u2019s lymphoma in a 14-year-old girl: a case report"],"prefix":"10.1186","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1588-3067","authenticated-orcid":false,"given":"Yumiko","family":"Ishizuka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiya","family":"Horimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kozue","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumi","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Onagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsue","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"850_CR1","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1002\/1097-0142(197705)39:5<2033::AID-CNCR2820390520>3.0.CO;2-V","volume":"39","author":"NC Mambo","year":"1977","unstructured":"Mambo NC, Burke JS, Butler JJ. Primary malignant lymphomas of the breast. Cancer. 1977;39:2033\u201340.","journal-title":"Cancer."},{"key":"850_CR2","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.anndiagpath.2005.09.018","volume":"10","author":"VE Duncan","year":"2006","unstructured":"Duncan VE, Reddy VVB, Jhala NC, Chhieng DC, Jhala DN. Non-Hodgkin's lymphoma of the breast: a review of 18 primary and secondary cases. Annals of Diagnostic Pathology. 2006;10:144\u20138.","journal-title":"Annals of Diagnostic Pathology."},{"key":"850_CR3","doi-asserted-by":"crossref","unstructured":"Thomas A, Link BK, Altekruse S, Romitti PA, Schroeder MC. Primary breast lymphoma in the United States: 1975\u20132013. 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Malignant breast cancer in children: a review of 75 patients. Journal of Surgical Research. 2008;147:182\u20138.","journal-title":"Journal of Surgical Research."},{"key":"850_CR10","doi-asserted-by":"crossref","unstructured":"Gao Y, Saksena MA, Brachtel EF, terMeulen DC, Rafferty EA. How to approach breast lesions in children and adolescents. European Journal of Radiology. 2015;84:1350-1364.","DOI":"10.1016\/j.ejrad.2015.04.011"},{"key":"850_CR11","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1007\/s12282-018-0906-0","volume":"26","author":"JT Hoang","year":"2019","unstructured":"Hoang JT, Yang R, Shah ZA, Spigel JJ, Pippen JE. Clinico-radiologic features and management of hematological tumors in the breast: a case series. 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