{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:35:31Z","timestamp":1762508131966},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,5,24]],"date-time":"2020-05-24T00:00:00Z","timestamp":1590278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,5,24]],"date-time":"2020-05-24T00:00:00Z","timestamp":1590278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Retroperitoneal liposarcoma (RPLS) is the most commonly observed soft tissue sarcoma in the retroperitoneal space. Although the beneficial effect of chemotherapy for RPLS is controversial, there are some reports that have shown a considerable tumor-suppressive effect of chemotherapy in RPLS. We demonstrate a case of dedifferentiated RPLS, which was initially considered inoperable but was successfully treated by neoadjuvant chemotherapy and subsequent curative resection.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>A 59-year-old female was referred to our hospital with a chief complaint of right lower quadrant abdominal pain. Abdominal computed tomography revealed a large retroperitoneal tumor with a maximum diameter of 11\u2009cm. The tumor involved retroperitoneal major vasculatures, such as the right common iliac vein and artery, as well as the right psoas muscle and femoral nerve. The right ureter was also involved and obstructed by the tumor. A biopsy was performed through the retroperitoneal route, and the tumor was diagnosed as a dedifferentiated liposarcoma with the F\u00e9d\u00e9ration Nationale des Centres de Lutte Contre le Cancer grade 3. Because the tumor was highly invasive and complete resection was not feasible, we decided to administer neoadjuvant chemotherapy with doxorubicin and ifosfamide (AI). After completing 6 courses of AI, the tumor size was considerably reduced, and we decided to perform surgery with curative intent. Before laparotomy, femoro-femoral arterial bypass was performed to prepare for the right common iliac artery resection. Thereafter, the patient underwent laparotomy and tumor resection combined with right nephrectomy, resection of the right common iliac artery and vein, and resection of the right psoas muscle and femoral nerve. The postoperative course was uneventful, although the patient needed a walking brace to support her gait. The pathological findings indicated a 99% disappearance of tumor cells. The patient was healthy without any complaints after 1\u2009year of surgery, and a follow-up CT scan revealed no tumor recurrence.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>To the best of our knowledge, this is the first report that showed a nearly complete pathological response to AI in dedifferentiated RPLS, which was subsequently completely resected.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s40792-020-00865-2","type":"journal-article","created":{"date-parts":[[2020,5,24]],"date-time":"2020-05-24T10:02:33Z","timestamp":1590314553000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A case of retroperitoneal dedifferentiated liposarcoma successfully treated by neoadjuvant chemotherapy and subsequent surgery"],"prefix":"10.1186","volume":"6","author":[{"given":"Yukihiro","family":"Yokoyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Ikuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Nagino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,24]]},"reference":[{"key":"865_CR1","doi-asserted-by":"crossref","unstructured":"Sassa N, Yokoyama Y, Nishida Y, Yamada S, Uchida H, Kajiyama H, et al. Clinical characteristics and surgical outcomes of retroperitoneal tumors: a comprehensive data collection from multiple departments. Int J Clin Oncol. 2020;in press.","DOI":"10.1007\/s10147-020-01620-1"},{"issue":"3","key":"865_CR2","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1245\/s10434-017-6081-2","volume":"25","author":"M Albertsmeier","year":"2018","unstructured":"Albertsmeier M, Rauch A, Roeder F, Hasenhutl S, Pratschke S, Kirschneck M, et al. External beam radiation therapy for resectable soft tissue sarcoma: a systematic review and meta-analysis. Ann Surg Oncol. 2018;25(3):754\u201367.","journal-title":"Ann Surg Oncol."},{"issue":"5","key":"865_CR3","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.ejso.2018.02.001","volume":"44","author":"LM Almond","year":"2018","unstructured":"Almond LM, Gronchi A, Strauss D, Jafri M, Ford S, Desai A. Neoadjuvant and adjuvant strategies in retroperitoneal sarcoma. Eur J Surg Oncol. 2018;44(5):571\u20139.","journal-title":"Eur J Surg Oncol."},{"issue":"6","key":"865_CR4","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1002\/jso.24221","volume":"113","author":"H Cheng","year":"2016","unstructured":"Cheng H, Miura JT, Lalehzari M, Rajeev R, Donahue AE, Bedi M, et al. Neoadjuvant radiotherapy for retroperitoneal sarcoma: a systematic review. J Surg Oncol. 2016;113(6):628\u201334.","journal-title":"J Surg Oncol."},{"issue":"2-3","key":"865_CR5","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1159\/000085704","volume":"68","author":"B Kasper","year":"2005","unstructured":"Kasper B, Ho AD, Egerer G. Is there an indication for high-dose chemotherapy in the treatment of bone and soft-tissue sarcoma? Oncology. 2005;68(2-3):115\u201321.","journal-title":"Oncology."},{"issue":"6","key":"865_CR6","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1177\/1758834017705588","volume":"9","author":"S Pasquali","year":"2017","unstructured":"Pasquali S, Gronchi A. Neoadjuvant chemotherapy in soft tissue sarcomas: latest evidence and clinical implications. Ther Adv Med Oncol. 2017;9(6):415\u201329.","journal-title":"Ther Adv Med Oncol."},{"issue":"4","key":"865_CR7","doi-asserted-by":"publisher","first-page":"974","DOI":"10.4103\/0973-1482.158032","volume":"11","author":"T Kus","year":"2015","unstructured":"Kus T, Aktas G, Kalender ME, Tutar E, Ulker E, Camci C. Complete response of a recurrent-metastatic liposarcoma with dedifferentiated histological features following the administration of trabectedin and review of literature. J Cancer Res Ther. 2015;11(4):974\u20136.","journal-title":"J Cancer Res Ther."},{"issue":"5","key":"865_CR8","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1067\/j.cpradiol.2013.02.001","volume":"42","author":"S Osman","year":"2013","unstructured":"Osman S, Lehnert BE, Elojeimy S, Cruite I, Mannelli L, Bhargava P, et al. A comprehensive review of the retroperitoneal anatomy, neoplasms, and pattern of disease spread. Curr Probl Diagn Radiol. 2013;42(5):191\u2013208.","journal-title":"Curr Probl Diagn Radiol."},{"issue":"1","key":"865_CR9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/jso.24927","volume":"117","author":"MY Zaidi","year":"2018","unstructured":"Zaidi MY, Canter R, Cardona K. Post-operative surveillance in retroperitoneal soft tissue sarcoma: the importance of tumor histology in guiding strategy. J Surg Oncol. 2018;117(1):99\u2013104.","journal-title":"J Surg Oncol."},{"issue":"8","key":"865_CR10","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1002\/cncr.31927","volume":"125","author":"RLM Haas","year":"2019","unstructured":"Haas RLM, Bonvalot S, Miceli R, Strauss DC, Swallow CJ, Hohenberger P, et al. Radiotherapy for retroperitoneal liposarcoma: a report from the Transatlantic Retroperitoneal Sarcoma Working Group. Cancer. 2019;125(8):1290\u2013300.","journal-title":"Cancer."},{"key":"865_CR11","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.2147\/DDDT.S92395","volume":"9","author":"R De Sanctis","year":"2015","unstructured":"De Sanctis R, Marrari A, Marchetti S, Mussi C, Balzarini L, Lutman FR, et al. Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma. Drug Des Devel Ther. 2015;9:5785\u201391.","journal-title":"Drug Des Devel Ther"},{"issue":"5","key":"865_CR12","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1002\/cncr.10794","volume":"95","author":"F Meric","year":"2002","unstructured":"Meric F, Hess KR, Varma DG, Hunt KK, Pisters PW, Milas KM, et al. Radiographic response to neoadjuvant chemotherapy is a predictor of local control and survival in soft tissue sarcomas. Cancer. 2002;95(5):1120\u20136.","journal-title":"Cancer."},{"issue":"6","key":"865_CR13","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/S1470-2045(10)70071-1","volume":"11","author":"RD Issels","year":"2010","unstructured":"Issels RD, Lindner LH, Verweij J, Wust P, Reichardt P, Schem BC, et al. Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study. Lancet Oncol. 2010;11(6):561\u201370.","journal-title":"Lancet Oncol."},{"key":"865_CR14","doi-asserted-by":"crossref","unstructured":"Paioli A, Setola E, Palmerini E, Cesari M, Longhi A. Experience with eribulin in pretreated patients with advanced liposarcoma: a case series. Future Oncol. 2019;20.","DOI":"10.2217\/fon-2019-0599"},{"issue":"7-8","key":"865_CR15","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1159\/000500608","volume":"42","author":"C Langmans","year":"2019","unstructured":"Langmans C, Cornillie J, van Cann T, Wozniak A, Hompes D, Sciot R, et al. Retrospective analysis of patients with advanced liposarcoma in a tertiary referral center. Oncol Res Treat. 2019;42(7-8):396\u2013404.","journal-title":"Oncol Res Treat."},{"issue":"6","key":"865_CR16","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1080\/13543784.2019.1607291","volume":"28","author":"FE Chamberlain","year":"2019","unstructured":"Chamberlain FE, Wilding C, Jones RL, Huang P. Pazopanib in patients with advanced intermediate-grade or high-grade liposarcoma. Expert Opin Investig Drugs. 2019;28(6):505\u201311.","journal-title":"Expert Opin Investig Drugs."},{"issue":"1","key":"865_CR17","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1186\/s12885-018-4749-z","volume":"18","author":"N Zhou","year":"2018","unstructured":"Zhou N, Schafer R, Li T, Fang M, Liu L. A primary undifferentiated pleomorphic sarcoma of the lumbosacral region harboring a LMNA-NTRK1 gene fusion with durable clinical response to crizotinib: a case report. BMC Cancer. 2018;18(1):842.","journal-title":"BMC Cancer."},{"issue":"7","key":"865_CR18","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1001\/jamaoncol.2016.0264","volume":"2","author":"MA Dickson","year":"2016","unstructured":"Dickson MA, Schwartz GK, Keohan ML, D'Angelo SP, Gounder MM, Chi P, et al. Progression-free survival among patients with well-differentiated or dedifferentiated liposarcoma treated with CDK4 inhibitor palbociclib: a phase 2 clinical trial. JAMA Oncol. 2016;2(7):937\u201340.","journal-title":"JAMA Oncol."},{"key":"865_CR19","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ejca.2016.12.018","volume":"75","author":"EAC Wiemer","year":"2017","unstructured":"Wiemer EAC, Wozniak A, Burger H, Smid M, Floris G, Nzokirantevye A, et al. Identification of microRNA biomarkers for response of advanced soft tissue sarcomas to eribulin: translational results of the EORTC 62052 trial. Eur J Cancer. 2017;75:33\u201340.","journal-title":"Eur J Cancer."}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-020-00865-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40792-020-00865-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-020-00865-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,23]],"date-time":"2021-05-23T23:06:38Z","timestamp":1621811198000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-020-00865-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,24]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["865"],"URL":"https:\/\/doi.org\/10.1186\/s40792-020-00865-2","relation":{},"ISSN":["2198-7793"],"issn-type":[{"value":"2198-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,24]]},"assertion":[{"value":"13 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"When obtaining informed consent for admission and the surgical procedure, general consent was also obtained from the patient for publication and presentation.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this report and the use of any accompanying images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests regarding this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"105"}}