{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:13:47Z","timestamp":1770754427897,"version":"3.50.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Appendectomy for acute appendicitis (AA) is considered one of the most common emergency surgeries. However, emergency appendectomy accompanied with complex lesions such as extensive abscess formation is not recommended in most cases. Therefore, non-operative management followed by interval appendectomy (IA) for AA has been tried. Herein, we present three AA cases with specific etiology that underwent interval appendectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p><jats:italic>Case 1<\/jats:italic>: A 68-year-old man was diagnosed AA with intestinal malrotation and intra-abdominal abscesses. He initially treated with conservative therapy and underwent laparoscopic IA after detailed preoperative examination.<\/jats:p><jats:p><jats:italic>Case 2<\/jats:italic>: A 22-year-old man had been under treatment for pancolitis-type ulcerative colitis (UC), also bothered by right-lower abdominal pain several times a year. The appendix always appeared swollen on every CT taken during symptoms. He underwent laparoscopic IA; pathological finding revealed typical UC histological features in the resected appendix. After the surgery, he never suffered from terrible right lower abdominal pain.<\/jats:p><jats:p><jats:italic>Case 3<\/jats:italic>: A 69-year-old woman complaining a right lower abdominal pain had undergone CT examination, which revealed AA with appendiceal mass, irregular wall thickness of the cecum, and mediastinal and para-aortic lymph node swelling. The operation was carried out after conservative therapy. The pathological diagnosis revealed<jats:italic>BRAF<\/jats:italic>mutated colorectal carcinoma. She had received systematic chemotherapy after the surgery, and all metastatic lesions have completely disappeared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Interval appendectomy provided us with much clearer anatomical information and precise therapeutic strategies, avoiding technical and general operative complications, and also induced fast recovery and short length of hospital stay. Interval appendectomy is a reasonable procedure and could be recommended in case of AA with some different etiology.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s40792-020-00971-1","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T14:02:33Z","timestamp":1597240953000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Validating the efficacy of interval appendectomy for acute appendicitis: representative three cases with different etiologies"],"prefix":"10.1186","volume":"6","author":[{"given":"Yuta","family":"Kasagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Natsugoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiko","family":"Aoyagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinari","family":"Nobutou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Tsujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sosei","family":"Kuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Takizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"key":"971_CR1","doi-asserted-by":"publisher","first-page":"213","DOI":"10.4103\/0974-2700.99683","volume":"5","author":"B Quartey","year":"2012","unstructured":"Quartey B. Interval appendectomy in adults: a necessary evil? J Emerg Trauma Shock. 2012;5:213\u20136.","journal-title":"J Emerg Trauma Shock"},{"key":"971_CR2","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1097\/01.sla.0000231726.53487.dd","volume":"244","author":"MF Ditillo","year":"2006","unstructured":"Ditillo MF, Dziura JD, Rabinovici R. Is it safe to delay appendectomy in adults with acute appendicitis? Ann Surg. 2006;244:656\u201360.","journal-title":"Ann Surg"},{"key":"971_CR3","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1177\/000313481107700727","volume":"77","author":"N Udgiri","year":"2011","unstructured":"Udgiri N, Curras E, Kella VK, Nagpal K, Cosgrove J. Appendicitis, is it an emergency? Am Surg. 2011;77:898\u2013901.","journal-title":"Am Surg"},{"key":"971_CR4","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1097\/00000658-199406000-00017","volume":"219","author":"RC Frazee","year":"1994","unstructured":"Frazee RC, Roberts JW, Symmonds RE, Snyder SK, Hen-dricks JC, Smith RW, et al. A prospective randomized trial comparing open versus laparoscopic appendectomy. Ann Surg. 1994;219:725\u20138.","journal-title":"Ann Surg"},{"key":"971_CR5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/01.sla.0000103071.35986.c1","volume":"239","author":"U Guller","year":"2004","unstructured":"Guller U, Hervey S, Purves H, Muhlbaier LH, Peterson ED, Eubanks S, et al. Laparoscopic versus open appendectomy: outcomes comparison based on a large administrative database. Ann Surg. 2004;239:43\u201352.","journal-title":"Ann Surg"},{"key":"971_CR6","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1308\/1478708051649","volume":"87","author":"I Ahmed","year":"2005","unstructured":"Ahmed I, Deakin D, Parsons SL. Appendix mass: do we know how to treat it? Ann R Coll Surg Engl. 2005;87:191\u20135.","journal-title":"Ann R Coll Surg Engl"},{"key":"971_CR7","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1007\/BF02235479","volume":"44","author":"D Oliak","year":"2001","unstructured":"Oliak D, Yamini D, Udani VM, Lewis RJ, Arnell T, Vargas H, et al. Initial nonoperative management for periappendiceal abscess. Dis Colon Rectum. 2001;44:936\u201341.","journal-title":"Dis Colon Rectum"},{"key":"971_CR8","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1097\/00000658-198211000-00013","volume":"196","author":"E Skoubo-Kristensen","year":"1982","unstructured":"Skoubo-Kristensen E, Hvid I. The appendiceal mass: results of conservative management. Ann Surg. 1982;196:584\u20137.","journal-title":"Ann Surg"},{"key":"971_CR9","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/0002-9610(84)90476-8","volume":"148","author":"J Hoffmann","year":"1984","unstructured":"Hoffmann J, Lindhard A, Jensen HE. Appendix mass: conservative management without interval appendectomy. Am J Surg. 1984;148:379\u201382.","journal-title":"Am J Surg"},{"key":"971_CR10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1742-1241.1996.tb09514.x","volume":"50","author":"SA Adalla","year":"1996","unstructured":"Adalla SA. Appendiceal mass: interval appendicectomy should not be the rule. Br J Clin Pract. 1996;50:168\u20139.","journal-title":"Br J Clin Pract"},{"key":"971_CR11","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1007\/s00268-005-0128-4","volume":"30","author":"HW Lai","year":"2006","unstructured":"Lai HW, Loong CC, Chiu JH, Chau GY, Wu CW, Lui WY. Interval appendectomy after conservative treatment of an appendiceal mass. World J Surg. 2006;30:352\u20137.","journal-title":"World J Surg"},{"key":"971_CR12","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1016\/S0140-6736(11)60410-8","volume":"377","author":"C Vons","year":"2011","unstructured":"Vons C, Barry C, Maitre S, Pautrat K, Leconte M, Costaglioli B, et al. Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open- label, non-inferiority, randomized controlled trial. Lancet. 2011;377:1573\u20139.","journal-title":"Lancet"},{"key":"971_CR13","doi-asserted-by":"publisher","first-page":"5849","DOI":"10.3748\/wjg.v23.i32.5849","volume":"23","author":"T Hori","year":"2017","unstructured":"Hori T, Machimoto T, Kadokawa Y, Hata T, Ito T, Kato S, et al. Laparoscopic appendectomy for acute appendicitis: how to discourage surgeons using inadequate therapy. World J Gastroenterol. 2017;23:5849\u201359.","journal-title":"World J Gastroenterol"},{"key":"971_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00595-006-3334-2","volume":"37","author":"L Corfield","year":"2007","unstructured":"Corfield L. Interval appendicectomy after appendiceal mass or abscess in adults: what is \u201cbest practice\u201d? Surg Today. 2007;37:1\u20134.","journal-title":"Surg Today"},{"key":"971_CR15","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1097\/SLA.0b013e31811f3f9f","volume":"246","author":"RE Andersson","year":"2007","unstructured":"Andersson RE, Petzold MG. Nonsurgical treatment of appendiceal abscess or phlegmon: a systematic review and meta-analysis. Ann Surg. 2007;246:741\u20138.","journal-title":"Ann Surg"},{"key":"971_CR16","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.jamcollsurg.2016.07.015","volume":"223","author":"S Lare","year":"2016","unstructured":"Lare S, Raminder N, Brandon B, Richard N. Interval appendectomy: Finding the breaking point for cost-effectiveness. J Am Coll Surg. 2016;223:632\u201343.","journal-title":"J Am Coll Surg"},{"key":"971_CR17","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/S1726-4901(09)70159-5","volume":"68","author":"WL Hung","year":"2005","unstructured":"Hung WL, Che CL, Chew WW, Wing YL. Watchful waiting versus Interval appendectomy for patients who recovered from acute appendicitis with tumor formation: a cost-effectiveness analysis. J Chin Med Assoc. 2005;68:431\u20134.","journal-title":"J Chin Med Assoc"},{"key":"971_CR18","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/S0140-6736(94)91841-4","volume":"343","author":"AE Gent","year":"1994","unstructured":"Gent AE, Hellier MD, Grace RH, Swarbrick ET, Coggon D. Inflammatory bowel disease and domestic hygiene in infancy. Lancet. 1994;343:766\u20137.","journal-title":"Lancet"},{"key":"971_CR19","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/0016-5085(94)90016-7","volume":"106","author":"P Rutgeerts","year":"1994","unstructured":"Rutgeerts P, D\u2019Haens G, Hiele M, Geboes K, Vantrappen G. Appendectomy protects against ulcerative colitis. Gastroenterology. 1994;106:1251\u20133.","journal-title":"Gastroenterology"},{"key":"971_CR20","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1136\/gut.43.4.494","volume":"43","author":"AE Duggan","year":"1998","unstructured":"Duggan AE, Usmani I, Neal KR, Logan RF. Appendicectomy, childhood hygiene, Helicobacter pylori status, and risk of inflammatory bowel disease: A case control study. Gut. 1998;43:494\u20138.","journal-title":"Gut"},{"key":"971_CR21","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1097\/00042737-199806000-00003","volume":"10","author":"MG Russel","year":"1998","unstructured":"Russel MG, Stockbrugger RW. Is appendectomy a causative factor in ulcerative colitis? Eur J Gastroenterol Hepatol. 1998;10:455\u20137.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"971_CR22","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1136\/gut.43.4.451","volume":"43","author":"A Ekbom","year":"1998","unstructured":"Ekbom A. Appendicectomy and childhood hygiene: Different sides of the same coin? Gut. 1998;43:451.","journal-title":"Gut"},{"key":"971_CR23","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.ejso.2010.05.025","volume":"36","author":"F Benedix","year":"2010","unstructured":"Benedix F. Primary appendiceal carcinoma epidemiology, surgery and survival: results of a German multi-center study. EJSO. 2010;36:763\u201371.","journal-title":"EJSO."},{"key":"971_CR24","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1097\/00000658-199401000-00009","volume":"219","author":"SS Nitecki","year":"1994","unstructured":"Nitecki SS. The natural history of surgically treated primary adenocarcinoma of the appendix. Ann Surg. 1994;219:51\u20137.","journal-title":"Ann Surg"},{"key":"971_CR25","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1093\/annonc\/mdr279","volume":"23","author":"CH Lieu","year":"2012","unstructured":"Lieu CH. Systemic chemotherapy and surgical cytoreduction for poorly differentiated and signet ring cell adenocarcinomas of the appendix. Ann Oncol. 2012;23:652\u20138.","journal-title":"Ann Oncol"},{"key":"971_CR26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/000313481608200107","volume":"82","author":"G Darwazeh","year":"2016","unstructured":"Darwazeh G, Cunningham SC, Kowdley GC. A systematic review of perforated appendicitis and phlegmon: interval appendectomy or wait-and-see? Am Surg. 2016;82:11\u20135.","journal-title":"Am Surg"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-020-00971-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40792-020-00971-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-020-00971-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T17:22:14Z","timestamp":1696526534000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-020-00971-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,12]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["971"],"URL":"https:\/\/doi.org\/10.1186\/s40792-020-00971-1","relation":{},"ISSN":["2198-7793"],"issn-type":[{"value":"2198-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,12]]},"assertion":[{"value":"8 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The present study was conducted in accordance with the ethical standards of our institution.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent was obtained from the patient and patient\u2019s family for the publication of this case report and accompanying images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"We have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"207"}}