{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:41:47Z","timestamp":1782963707876,"version":"3.54.5"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Spontaneous regression (SR) of a malignant tumor is the partial or complete disappearance of primary or metastatic tumor tissue in the absence of treatment, which can be temporary or permanent. Here, we report an extremely rare case of male breast cancer that exhibited temporary SR followed by reappearance 8\u00a0months after tumor disappearance.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>A 70-year-old man presented at our hospital with a primary complaint of pain and a lump in his left breast. Ultrasonography revealed a hypoechoic lesion measuring 12\u00a0mm\u2009\u00d7\u200910\u00a0mm\u2009\u00d7\u20098\u00a0mm. Fine-needle aspiration cytology revealed numerous necrotic and degenerated cells and few sheet-like clusters of atypical ductal epithelial cells. The atypical cells had mildly enlarged nuclei with nucleoli, were focally overlapped and formed tubular patterns. The cytological diagnosis indicated a suspicion of malignancy. Core needle biopsy (CNB) revealed necrotic and degenerated cells with microcalcification. The pathological diagnosis was indeterminate because there was no area of viable atypical cells. An excisional biopsy of the left breast lesion was scheduled one month later. However, it was difficult to detect the tumor during physical examination and ultrasonography performed 1 month after the patient\u2019s first visit. The operation was canceled, and the patient received follow-up observation. After 8\u00a0months of follow-up, ultrasonography and computed tomography (CT) revealed reappearance of a 0.6-cm-diameter breast tumor in the same place. CNB was performed again and revealed invasive ductal carcinoma. A total mastectomy with sentinel lymph node biopsy was performed 13\u00a0months after the first tumor disappeared. Histopathological examination revealed invasive cribriform carcinoma without sentinel lymph node metastasis. The patient did not have any complications, and adjuvant therapy with tamoxifen was started. The patient was alive without recurrence 7\u00a0months after surgery.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Temporary SR followed by tumor reappearance can occur in breast cancer cases, and it is important to follow patients even if their breast tumor has seemingly disappeared. When breast tumors disappear without treatment, clinicians must be aware of the possibility of SR of cancer and should follow the patient for early detection of tumor reappearance.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s40792-020-01088-1","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T12:04:20Z","timestamp":1607342660000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Temporary spontaneous regression of male breast cancer: a case report"],"prefix":"10.1186","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0795-7193","authenticated-orcid":false,"given":"Kaoru","family":"Katano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Yoshimitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kyuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Haba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiko","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,7]]},"reference":[{"key":"1088_CR1","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1097\/00000658-195609000-00007","volume":"144","author":"TC Everson","year":"1956","unstructured":"Everson TC, Cole WH. Spontaneous regression of cancer: preliminary report. Ann Surg. 1956;144:366\u201380.","journal-title":"Ann Surg"},{"key":"1088_CR2","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s13256-015-0702-9","volume":"9","author":"A Lopez-Pastorini","year":"2015","unstructured":"Lopez-Pastorini A, Pl\u00f6nes T, Brockmann M, Ludwig C, Beckers F, Stoelben E. Spontaneous regression of non-small cell lung cancer after biopsy of a mediastinal lymph node metastasis: a case report. J Med Case Rep. 2015;9:217.","journal-title":"J Med Case Rep"},{"key":"1088_CR3","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3109\/02841869009090048","volume":"29","author":"GB Challis","year":"1990","unstructured":"Challis GB, Stam HJ. The spontaneous regression of cancer: a review of cases from 1900 to 1987. Acta Oncol. 1990;29:545\u201350.","journal-title":"Acta Oncol"},{"key":"1088_CR4","first-page":"4371","volume":"7","author":"E Tokunaga","year":"2014","unstructured":"Tokunaga E, Okano S, Nakashima Y, Yamashita N, Tanaka K, Akiyoshi S, et al. Spontaneous regression of breast cancer with axillary lymph node metastasis: a case report and review of literature. Int J Clin Exp Pathol. 2014;7:4371\u201380.","journal-title":"Int J Clin Exp Pathol"},{"key":"1088_CR5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2147\/ITT.S163924","volume":"7","author":"LF Vernon","year":"2018","unstructured":"Vernon LF. William Bradley Coley, MD, and the phenomenon of spontaneous regression. Immunotargets Ther. 2018;7:29\u201334.","journal-title":"Immunotargets Ther"},{"key":"1088_CR6","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ijscr.2019.09.017","volume":"63","author":"S Takayama","year":"2019","unstructured":"Takayama S, Satomi K, Yoshida M, Watase C, Murata T, Shiino S, et al. Spontaneous regression of occult breast cancer with axillary lymph node metastasis: a case report. Int J Surg Case Rep. 2019;63:75\u20139.","journal-title":"Int J Surg Case Rep"},{"key":"1088_CR7","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1016\/0959-8049(94)E0182-4","volume":"30A","author":"AG Maiche","year":"1994","unstructured":"Maiche AG, Jekunen A, Rissanen P, Virkkunen P, Halavaara J, Turunen JP. Sudden tumour regression with enhanced natural killer cell accumulation in a patient with stage IV breast cancer. Eur J Cancer. 1994;30A:1642\u20136.","journal-title":"Eur J Cancer"},{"key":"1088_CR8","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1159\/000112228","volume":"65","author":"C Dussan","year":"2008","unstructured":"Dussan C, Zubor P, Fernandez M, Yabar A, Szunyogh N, Visnovsky J. Spontaneous regression of a breast carcinoma: a case report. Gynecol Obstet Invest. 2008;65:206\u201311.","journal-title":"Gynecol Obstet Invest"},{"key":"1088_CR9","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ijscr.2016.06.017","volume":"25","author":"E Ito","year":"2016","unstructured":"Ito E, Nakano S, Otsuka M, Mibu A, Karikomi M, Oinuma T, et al. Spontaneous breast cancer remission: a case report. Int J Surg Case Rep. 2016;25:132\u20136.","journal-title":"Int J Surg Case Rep"},{"key":"1088_CR10","doi-asserted-by":"publisher","first-page":"139","DOI":"10.5114\/pjp.2019.87105","volume":"70","author":"G Cserni","year":"2019","unstructured":"Cserni G, Serfozo O, Ambr\u00f3zay \u00c9, Mark\u00f3 L, Kren\u00e1cs L. Spontaneous pathological complete regression of high-grade triple-negative breast cancer with axillary metastasis. Pol J Pathol. 2019;70:139\u201343.","journal-title":"Pol J Pathol"},{"key":"1088_CR11","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13694","author":"C Tomasini","year":"2020","unstructured":"Tomasini C. Cytotoxic-mediated spontaneous regression of inflammatory cutaneous metastases of breast carcinoma. J Cutan Pathol. 2020. https:\/\/doi.org\/10.1111\/cup.13694.","journal-title":"J Cutan Pathol"},{"key":"1088_CR12","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/j.1365-2559.1983.tb02265.x","volume":"7","author":"DL Page","year":"1983","unstructured":"Page DL, Dixon JM, Anderson TJ, Lee D, Stewart HJ. Invasive cribriform carcinoma of the breast. Histopathology. 1983;7:525\u201336.","journal-title":"Histopathology"},{"key":"1088_CR13","doi-asserted-by":"publisher","first-page":"145","DOI":"10.2325\/jbcs.12.145","volume":"12","author":"R Nishimura","year":"2005","unstructured":"Nishimura R, Ohsumi S, Teramoto N, Yamakawa T, Saeki T, Takashima S. Invasive cribriform carcinoma with extensive microcalcifications in the male breast. Breast Cancer. 2005;12:145\u20138.","journal-title":"Breast Cancer"},{"key":"1088_CR14","first-page":"121","volume-title":"WHO classification of tumours of the breast","author":"CHM van Deurzen","year":"2019","unstructured":"van Deurzen CHM, Denkert C, Purdie CA, et al. Cribriform carcinoma. In: Allison KH, Salgado R, Brogi E, Sapino A, Ellis IO, Sasano H, et al., editors. WHO classification of tumours of the breast. 5th ed. Lyon: IARC Press; 2019. p. 121\u20132.","edition":"5"},{"key":"1088_CR15","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/0046-8177(90)90235-W","volume":"21","author":"JG Venable","year":"1990","unstructured":"Venable JG, Schwartz AM, Silverberg SG. Infiltrating cribriform carcinoma of the breast: a distinctive clinicopathologic entity. Hum Pathol. 1990;21:333\u20138.","journal-title":"Hum Pathol"},{"key":"1088_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijscr.2016.04.040","volume":"24","author":"AM Salih","year":"2016","unstructured":"Salih AM, Kakamad FH. Spontaneous infarction of fibroadenoma of breast\u2014A case report with literature review. Int J Surg Case Rep. 2016;24:1\u20133.","journal-title":"Int J Surg Case Rep"},{"key":"1088_CR17","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.18203\/2349-2902.isj20180848","volume":"5","author":"P Agarwal","year":"2018","unstructured":"Agarwal P, Badkur M, Dausage C. Spontaneous infarction in fibroadenoma of breast: a rare pathological finding in a common pathological entity. Int Surg J. 2018;5:1145\u20138.","journal-title":"Int Surg J"},{"key":"1088_CR18","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s13691-018-00353-3","volume":"8","author":"T Uchida","year":"2019","unstructured":"Uchida T, Matsubara H, Sugimura A, Matsuoka H, Ichihara T, Nakajima H. Spontaneous regression of a carcinoid tumor that required resection owing to its reappearance and subsequent enlargement after 2 years: a case report. Int Cancer Conf J. 2019;8:58\u201360.","journal-title":"Int Cancer Conf J"},{"key":"1088_CR19","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s40792-017-0341-z","volume":"3","author":"K Chida","year":"2017","unstructured":"Chida K, Nakanishi K, Shomura H, Homma S, Hattori A, Kazui K, et al. Spontaneous regression of transverse colon cancer: a case report. Surg Case Rep. 2017;3:65.","journal-title":"Surg Case Rep"},{"key":"1088_CR20","doi-asserted-by":"publisher","first-page":"3797","DOI":"10.3748\/wjg.v23.i21.3797","volume":"23","author":"A Sakamaki","year":"2017","unstructured":"Sakamaki A, Kamimura K, Abe S, Tsuchiya A, Takamura M, Kawai H, et al. Spontaneous regression of hepatocellular carcinoma: a mini-review. World J Gastroenterol. 2017;23:3797\u2013804.","journal-title":"World J Gastroenterol"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-020-01088-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40792-020-01088-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-020-01088-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T12:34:50Z","timestamp":1607344490000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-020-01088-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1088"],"URL":"https:\/\/doi.org\/10.1186\/s40792-020-01088-1","relation":{},"ISSN":["2198-7793"],"issn-type":[{"value":"2198-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"29 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from the patient and the patient\u2019s family for the publication of this case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"311"}}