{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:34:16Z","timestamp":1762868056744},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Thoracic aortitis caused by <jats:italic>Clostridium septicum<\/jats:italic> is a rare infection with a strong association with malignancy and high mortality rate when left untreated. We report a case of surgical treatment for Stanford type A acute aortic dissection in a patient with <jats:italic>C. septicum<\/jats:italic> sepsis and thoracic aortitis.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>A 63-year-old hypertensive man with rheumatoid arthritis presented with general malaise and diagnosed with <jats:italic>C. septicum<\/jats:italic>-infected aortitis with sepsis. On the 5th day of hospitalization, Stanford type A acute aortic dissection developed with severe aortic regurgitation. The patient underwent emergent surgical treatment successfully with excision of the infected ascending aorta and aortic root followed by replacement using a composite graft, followed by diagnosis of sigmoid colon cancer 7 months after aortic surgery. He was scheduled to undergo elective colon surgery.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p><jats:italic>C. septicum<\/jats:italic> aortitis can progress quickly, causing aneurysm or dissection. Therefore, in a patient with <jats:italic>C. septicum<\/jats:italic> aortitis, prompt surgical in situ graft replacement should be performed to debride the infected vascular lesions. Further investigations for gastrointestinal and hematological malignancies as a source of <jats:italic>C. septicum<\/jats:italic> should be also conducted.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s40792-020-0770-y","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T15:03:53Z","timestamp":1579187033000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clostridium septicum-infected Stanford type A acute aortic dissection: a case report"],"prefix":"10.1186","volume":"6","author":[{"given":"Kiyotoshi","family":"Akita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Takami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Matsuhashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Amano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadahito","family":"Eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,16]]},"reference":[{"key":"770_CR1","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1001\/jama.1969.03160160021004","volume":"209","author":"RJ Alpern","year":"1969","unstructured":"Alpern RJ, Dowell VR Jr. Clostridium septicum infections and malignancy. 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J Clin Med Res. 2016;8:168\u201374.","journal-title":"J Clin Med Res"},{"key":"770_CR5","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s13256-017-1422-0","volume":"11","author":"F Ito","year":"2017","unstructured":"Ito F, Inokuchi R, Matsumoto A, et al. Presence of periaortic gas in Clostridium septicum-infected aortic aneurysm aids in early diagnosis: a case report and systematic review of the literature. J Med Case Rep. 2017;11:268.","journal-title":"J Med Case Rep"},{"key":"770_CR6","doi-asserted-by":"publisher","first-page":"314.e5","DOI":"10.1016\/j.avsg.2017.03.178","volume":"43","author":"Y Alimi","year":"2017","unstructured":"Alimi Y, Sosin M, Borsinger TM, Garrett JR, Salameh JR, Espinel CF. Implications of Clostridium septicum in vascular surgery: a case report and outcomes literature review. Ann Vasc Surg. 2017;43:314.e5\u2013314.e11.","journal-title":"Ann Vasc Surg"},{"key":"770_CR7","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1001\/jamainternmed.2015.5389","volume":"175","author":"CC Lee","year":"2015","unstructured":"Lee CC, Lee MT, Chen YS, et al. Risk of aortic dissection and aortic aneurysm in patients taking oral fluoroquinolone. JAMA Intern Med. 2015;175:1839\u201347.","journal-title":"JAMA Intern Med"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-020-0770-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40792-020-0770-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40792-020-0770-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:06:50Z","timestamp":1610669210000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicalcasereports.springeropen.com\/articles\/10.1186\/s40792-020-0770-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,16]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["770"],"URL":"https:\/\/doi.org\/10.1186\/s40792-020-0770-y","relation":{},"ISSN":["2198-7793"],"issn-type":[{"value":"2198-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,16]]},"assertion":[{"value":"9 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethics approval and consent to publish have been obtained from the participant.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from the patient for the publication of this case report and any accompanying figures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23"}}