{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:53:49Z","timestamp":1740174829409,"version":"3.37.3"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:00:00Z","timestamp":1586476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:00:00Z","timestamp":1586476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["surg case rep"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Patients with prolonged inflammatory bowel disease have a greater risk of colorectal cancer, known as colitis-associated cancer. Here we describe an unusual case of colitis-associated cancer.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>The subject is a 41-year-old male who has not presented digestive symptoms and has an appreciable medical history. He consulted a nearby doctor with left flank pain. A colonoscopy revealed a lateral spreading tumor (granular-type) in his descending colon. With a clinical diagnosis of cancer, D3 left hemicolectomy was performed and a small intestine stoma was constructed. The pathological diagnosis of the tumor was mucinous adenocarcinoma, pT4a(SE), pN2a, which was associated with dysplasia in the surface area. Post-operative ileus was prolonged and the endoscopic examination revealed longitudinal ulcers in the ileum. These ulcers responded quite well to the administration of infliximab, confirming the final diagnosis of Crohn\u2019s disease. Pathological re-examination revealed that the tumor was dysplasia-associated type, and another dysplasia was confirmed near the tumor. Furthermore, mural scars and sporadic lymphoid aggregates were noted in the colon tissues, which suggested pre-existing Crohn\u2019s disease. The patient died of peritoneal dissemination of cancer on day 207 after surgery.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The present case was diagnosed as colitis-associated cancer with clinically latent Crohn\u2019s disease, who developed clinically manifest Crohn\u2019s disease only after surgery. Our review of literature revealed no cases comparable to ours.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s40792-020-0779-2","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T04:42:19Z","timestamp":1586493739000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A patient with colitis-associated cancer who developed clinically manifest Crohn\u2019s disease only after surgery"],"prefix":"10.1186","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1853-7386","authenticated-orcid":false,"given":"Yoshio","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideya","family":"Takaku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sugiru","family":"Paku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Azuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshishige","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kashimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruo","family":"Ohtani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Ohkochi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,4,10]]},"reference":[{"key":"779_CR1","first-page":"373","volume":"108","author":"T Hisamatsu","year":"2011","unstructured":"Hisamatsu T, Hibi T. 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Dis Colon Rectum. 2000;43:85\u201393.","journal-title":"Dis Colon Rectum."},{"key":"779_CR5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1046\/j.1365-2036.2002.01140.x","volume":"16","author":"EV Loftus Jr","year":"2002","unstructured":"Loftus EV Jr, Schoenfeld P, Sandborn WJ. The epidemiology and natural history of Crohn\u2019s disease in population-based patient cohorts from North America: a systematic review. Aliment Pharmacol Ther. 2002;16:51\u201360.","journal-title":"Aliment Pharmacol Ther."},{"unstructured":"Matsui T1, Yano Y, Hirai F. Crohn\u2019s disease and intestinal cancer. Nihon Shokakibyo Gakkai Zasshi. 2006;103:797-804.","key":"779_CR6"},{"key":"779_CR7","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00535-012-0673-1","volume":"48","author":"F Ueno","year":"2013","unstructured":"Ueno F, Matsui T, Matsumoto T, et al. Evidence-based clinical practice guidelines for Crohn's disease, integrated with formal consensus of experts in Japan. 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